|
2009-12-30 |
2009-12-29 |
V
Vente
|
STUPPIN JOHN B
Administrateur non-exécutif
|
5 608
-3.0%
0,12
673 USD
|
5 608
-3.0%
|
0,12
|
673 USD
|
|
|
2009-10-26 |
2009-10-26 |
A
Achat
|
Firefly Value Partners, LP
Actionnaire important
|
81 561
+3.6%
0,90
73 397 USD
|
81 561
+3.6%
|
0,90
|
73 397 USD
|
|
|
2009-10-26 |
2009-10-26 |
A
Achat
|
Firefly Value Partners, LP
Actionnaire important
|
99 365
+3.6%
0,90
89 419 USD
|
99 365
+3.6%
|
0,90
|
89 419 USD
|
|
|
2009-10-26 |
2009-10-22 |
A
Achat
|
Firefly Value Partners, LP
Actionnaire important
|
135 442
+6.4%
0,91
123 022 USD
|
135 442
+6.4%
|
0,91
|
123 022 USD
|
|
|
2009-10-26 |
2009-10-22 |
A
Achat
|
Firefly Value Partners, LP
Actionnaire important
|
165 007
+6.4%
0,91
149 876 USD
|
165 007
+6.4%
|
0,91
|
149 876 USD
|
|
|
2009-10-23 |
2009-10-21 |
V
Vente
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Actionnaire important
|
2 692 493
-89.0%
0,91
2 450 169 USD
|
2 692 493
-89.0%
|
0,91
|
2 450 169 USD
|
|
|
2009-10-23 |
2009-10-21 |
V
Vente
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Actionnaire important
|
777 408
-20.4%
0,91
707 441 USD
|
777 408
-20.4%
|
0,91
|
707 441 USD
|
|
|
2009-10-23 |
2009-10-21 |
V
Vente
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Actionnaire important
|
1 136 494
-23.0%
0,91
1 034 210 USD
|
1 136 494
-23.0%
|
0,91
|
1 034 210 USD
|
|
|
2009-02-12 |
2008-12-17 |
V
Vente
|
FREIMAN PAUL E
Former officer and director
|
66
-0.4%
0,21
14 USD
|
66
-0.4%
|
0,21
|
14 USD
|
|
|
2009-02-12 |
2008-12-17 |
V
Vente
|
FREIMAN PAUL E
Former officer and director
|
400
-2.6%
0,21
84 USD
|
400
-2.6%
|
0,21
|
84 USD
|
|
|
2009-02-12 |
2008-12-16 |
V
Vente
|
FREIMAN PAUL E
Former officer and director
|
30
-0.2%
0,58
17 USD
|
30
-0.2%
|
0,58
|
17 USD
|
|
|
2009-02-12 |
2008-12-16 |
V
Vente
|
FREIMAN PAUL E
Former officer and director
|
970
-5.9%
0,56
543 USD
|
970
-5.9%
|
0,56
|
543 USD
|
|
|
2009-02-12 |
2008-12-10 |
V
Vente
|
FREIMAN PAUL E
Former officer and director
|
1 000
-5.8%
0,61
610 USD
|
1 000
-5.8%
|
0,61
|
610 USD
|
|
|
2008-11-18 |
2008-11-14 |
V
Vente
|
J P MORGAN CHASE & CO
Actionnaire important
|
2 962 340
-100.0%
0,48
1 410 666 USD
|
2 962 340
-100.0%
|
0,48
|
1 410 666 USD
|
|
|
2008-11-14 |
2008-11-12 |
A
Achat
|
Wasiewski Warren W
Vice President, CMO
Dirigeant
|
10 000
+inf%
0,66
6 600 USD
|
10 000
+inf%
|
0,66
|
6 600 USD
|
|
|
2008-11-13 |
2008-11-11 |
A
Achat
|
Fletcher William A
Administrateur non-exécutif
|
10 000
+17.1%
0,66
6 600 USD
|
10 000
+17.1%
|
0,66
|
6 600 USD
|
|
|
2008-10-30 |
2008-10-29 |
A
Achat
|
Fletcher William A
Administrateur non-exécutif
|
5 000
+9.3%
0,65
3 250 USD
|
5 000
+9.3%
|
0,65
|
3 250 USD
|
|
|
2008-10-30 |
2008-10-28 |
A
Achat
|
Fletcher William A
Administrateur non-exécutif
|
10 000
+22.9%
0,70
7 000 USD
|
10 000
+22.9%
|
0,70
|
7 000 USD
|
|
|
2008-10-23 |
2008-10-22 |
A
Achat
|
LOAR MATTHEW M
VP and Chief Financial Officer
Dirigeant
|
25 000
+inf%
0,75
18 750 USD
|
25 000
+inf%
|
0,75
|
18 750 USD
|
|
|
2008-10-16 |
2008-10-15 |
A
Achat
|
STUPPIN JOHN B
Administrateur non-exécutif
|
1 000
+0.6%
0,87
870 USD
|
1 000
+0.6%
|
0,87
|
870 USD
|
|
|
2008-10-16 |
2008-10-15 |
A
Achat
|
STUPPIN JOHN B
Administrateur non-exécutif
|
9 000
+5.5%
0,85
7 650 USD
|
9 000
+5.5%
|
0,85
|
7 650 USD
|
|
|
2008-10-20 |
2008-10-08 |
V
Vente
|
J P MORGAN CHASE & CO
Actionnaire important
|
158 300
-5.1%
0,44
69 652 USD
|
158 300
-5.1%
|
0,44
|
69 652 USD
|
|
|
2008-10-20 |
2008-10-07 |
V
Vente
|
J P MORGAN CHASE & CO
Actionnaire important
|
211 100
-6.3%
0,50
105 550 USD
|
211 100
-6.3%
|
0,50
|
105 550 USD
|
|
|
2008-10-20 |
2008-10-06 |
V
Vente
|
J P MORGAN CHASE & CO
Actionnaire important
|
3 304
-0.1%
0,47
1 553 USD
|
3 304
-0.1%
|
0,47
|
1 553 USD
|
|
|
2008-10-20 |
2008-10-03 |
V
Vente
|
J P MORGAN CHASE & CO
Actionnaire important
|
17 900
-0.5%
0,55
9 845 USD
|
17 900
-0.5%
|
0,55
|
9 845 USD
|
|
|
2008-10-20 |
2008-10-02 |
V
Vente
|
J P MORGAN CHASE & CO
Actionnaire important
|
41 550
-1.2%
0,53
22 022 USD
|
41 550
-1.2%
|
0,53
|
22 022 USD
|
|
|
2008-10-20 |
2008-10-01 |
V
Vente
|
J P MORGAN CHASE & CO
Actionnaire important
|
24 320
-0.7%
0,66
16 051 USD
|
24 320
-0.7%
|
0,66
|
16 051 USD
|
|
|
2008-10-20 |
2008-09-30 |
V
Vente
|
J P MORGAN CHASE & CO
Actionnaire important
|
2 700
-0.1%
0,65
1 755 USD
|
2 700
-0.1%
|
0,65
|
1 755 USD
|
|
|
2008-10-20 |
2008-09-29 |
V
Vente
|
J P MORGAN CHASE & CO
Actionnaire important
|
29 150
-0.8%
0,63
18 365 USD
|
29 150
-0.8%
|
0,63
|
18 365 USD
|
|
|
2008-10-20 |
2008-09-26 |
V
Vente
|
J P MORGAN CHASE & CO
Actionnaire important
|
71 100
-2.0%
0,72
51 192 USD
|
71 100
-2.0%
|
0,72
|
51 192 USD
|
|
|
2008-10-20 |
2008-09-25 |
V
Vente
|
J P MORGAN CHASE & CO
Actionnaire important
|
163 567
-4.4%
0,78
127 582 USD
|
163 567
-4.4%
|
0,78
|
127 582 USD
|
|
|
2008-10-20 |
2008-09-24 |
V
Vente
|
J P MORGAN CHASE & CO
Actionnaire important
|
38 423
-1.0%
0,89
34 196 USD
|
38 423
-1.0%
|
0,89
|
34 196 USD
|
|
|
2008-01-03 |
2007-12-31 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
50 000
+1.0%
2,88
144 000 USD
|
50 000
+1.0%
|
2,88
|
144 000 USD
|
|
|
2008-01-02 |
2007-12-31 |
V
Vente
|
KASPER F VAN
Administrateur non-exécutif
|
100
-0.2%
2,91
291 USD
|
100
-0.2%
|
2,91
|
291 USD
|
|
|
2008-01-02 |
2007-12-31 |
V
Vente
|
KASPER F VAN
Administrateur non-exécutif
|
14 119
-24.4%
2,90
40 945 USD
|
14 119
-24.4%
|
2,90
|
40 945 USD
|
|
|
2008-01-02 |
2007-12-31 |
V
Vente
|
KASPER F VAN
Administrateur non-exécutif
|
5 780
-9.1%
2,92
16 878 USD
|
5 780
-9.1%
|
2,92
|
16 878 USD
|
|
|
2007-12-28 |
2007-12-28 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
16 400
+0.3%
2,94
48 186 USD
|
16 400
+0.3%
|
2,94
|
48 186 USD
|
|
|
2007-12-28 |
2007-12-27 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
24 800
+0.5%
2,96
73 443 USD
|
24 800
+0.5%
|
2,96
|
73 443 USD
|
|
|
2007-12-28 |
2007-12-26 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
7 200
+0.1%
3,00
21 599 USD
|
7 200
+0.1%
|
3,00
|
21 599 USD
|
|
|
2007-12-21 |
2007-12-20 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
6 100
+0.1%
3,00
18 300 USD
|
6 100
+0.1%
|
3,00
|
18 300 USD
|
|
|
2007-12-21 |
2007-12-19 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
26 700
+0.6%
3,00
80 100 USD
|
26 700
+0.6%
|
3,00
|
80 100 USD
|
|
|
2007-12-18 |
2007-12-18 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
50 000
+1.0%
3,00
150 000 USD
|
50 000
+1.0%
|
3,00
|
150 000 USD
|
|
|
2007-12-18 |
2007-12-17 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
25 000
+0.5%
3,00
75 000 USD
|
25 000
+0.5%
|
3,00
|
75 000 USD
|
|
|
2007-12-18 |
2007-12-14 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
50 000
+1.1%
2,99
149 500 USD
|
50 000
+1.1%
|
2,99
|
149 500 USD
|
|
|
2007-12-18 |
2007-12-13 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
25 000
+0.5%
3,00
75 000 USD
|
25 000
+0.5%
|
3,00
|
75 000 USD
|
|
|
2007-12-18 |
2007-12-12 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
50 000
+1.1%
3,00
150 000 USD
|
50 000
+1.1%
|
3,00
|
150 000 USD
|
|
|
2007-12-11 |
2007-12-11 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
50 000
+1.1%
3,00
150 000 USD
|
50 000
+1.1%
|
3,00
|
150 000 USD
|
|
|
2007-12-11 |
2007-12-10 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
101 300
+2.3%
2,98
301 651 USD
|
101 300
+2.3%
|
2,98
|
301 651 USD
|
|
|
2007-12-11 |
2007-12-07 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
52 000
+1.2%
3,00
155 901 USD
|
52 000
+1.2%
|
3,00
|
155 901 USD
|
|
|
2007-12-05 |
2007-12-03 |
A
Achat
|
STUPPIN JOHN B
Administrateur non-exécutif
|
7 000
+4.4%
3,26
22 820 USD
|
7 000
+4.4%
|
3,26
|
22 820 USD
|
|
|
2007-12-05 |
2007-12-03 |
A
Achat
|
STUPPIN JOHN B
Administrateur non-exécutif
|
7 800
+5.2%
3,32
25 896 USD
|
7 800
+5.2%
|
3,32
|
25 896 USD
|
|
|
2007-12-05 |
2007-12-03 |
A
Achat
|
STUPPIN JOHN B
Administrateur non-exécutif
|
200
+0.1%
3,31
662 USD
|
200
+0.1%
|
3,31
|
662 USD
|
|
|
2007-12-05 |
2007-12-03 |
A
Achat
|
STUPPIN JOHN B
Administrateur non-exécutif
|
2 000
+1.4%
3,30
6 600 USD
|
2 000
+1.4%
|
3,30
|
6 600 USD
|
|
|
2007-12-05 |
2007-12-03 |
A
Achat
|
FREIMAN PAUL E
President and CEO
Administrateur exécutif
|
3 000
+20.9%
3,30
9 900 USD
|
3 000
+20.9%
|
3,30
|
9 900 USD
|
|
|
2007-11-29 |
2007-11-28 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
336 000
+8.2%
2,71
910 560 USD
|
336 000
+8.2%
|
2,71
|
910 560 USD
|
|
|
2007-11-29 |
2007-11-27 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
116 303
+2.9%
2,70
314 018 USD
|
116 303
+2.9%
|
2,70
|
314 018 USD
|
|
|
2007-11-26 |
2007-11-26 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
20 500
+0.5%
2,58
52 890 USD
|
20 500
+0.5%
|
2,58
|
52 890 USD
|
|
|
2007-11-26 |
2007-11-21 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
188 988
+5.0%
2,40
453 571 USD
|
188 988
+5.0%
|
2,40
|
453 571 USD
|
|
|
2007-11-19 |
2007-11-19 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
23 200
+0.6%
2,49
57 875 USD
|
23 200
+0.6%
|
2,49
|
57 875 USD
|
|
|
2007-11-19 |
2007-11-15 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
29 700
+0.8%
2,46
73 166 USD
|
29 700
+0.8%
|
2,46
|
73 166 USD
|
|
|
2007-11-15 |
2007-11-14 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
8 600
+0.2%
2,40
20 640 USD
|
8 600
+0.2%
|
2,40
|
20 640 USD
|
|
|
2007-11-15 |
2007-11-13 |
A
Achat
|
HIGHLAND CAPITAL MANAGEMENT LP
Actionnaire important
|
57 000
+1.6%
2,39
136 127 USD
|
57 000
+1.6%
|
2,39
|
136 127 USD
|
|
|
2008-06-26 |
2007-11-06 |
A
Achat
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Actionnaire important
|
29 000
+0.6%
2,43
70 392 USD
|
29 000
+0.6%
|
2,43
|
70 392 USD
|
|
|
2008-06-26 |
2007-11-06 |
A
Achat
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Actionnaire important
|
7 000
+0.1%
2,43
16 991 USD
|
7 000
+0.1%
|
2,43
|
16 991 USD
|
|
|
2008-06-26 |
2007-11-06 |
A
Achat
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Actionnaire important
|
11 000
+0.2%
2,43
26 700 USD
|
11 000
+0.2%
|
2,43
|
26 700 USD
|
|
|
2007-11-06 |
2007-11-02 |
A
Achat
|
STUPPIN JOHN B
Administrateur non-exécutif
|
43 600
+42.0%
2,75
119 900 USD
|
43 600
+42.0%
|
2,75
|
119 900 USD
|
|
|
2007-11-06 |
2007-11-02 |
A
Achat
|
Fletcher William A
Administrateur non-exécutif
|
43 600
+inf%
2,75
119 900 USD
|
43 600
+inf%
|
2,75
|
119 900 USD
|
|
|
2007-11-06 |
2007-11-02 |
A
Achat
|
COHEN ABRAHAM E
Administrateur non-exécutif
|
43 600
+58.1%
2,75
119 900 USD
|
43 600
+58.1%
|
2,75
|
119 900 USD
|
|
|
2007-11-06 |
2007-11-02 |
A
Achat
|
SOFAER ABRAHAM D
Administrateur non-exécutif
|
43 600
+64.8%
2,75
119 900 USD
|
43 600
+64.8%
|
2,75
|
119 900 USD
|
|
|
2007-11-01 |
2007-10-31 |
A
Achat
|
CARLSON CRAIG W
VP and Chief Financial Officer
Dirigeant
|
1 000
+inf%
2,62
2 620 USD
|
1 000
+inf%
|
2,62
|
2 620 USD
|
|
|
2007-11-13 |
2007-10-30 |
A
Achat
|
Levy David E
VP of Clinical Development
Dirigeant
|
10 000
+321.0%
2,63
26 300 USD
|
10 000
+321.0%
|
2,63
|
26 300 USD
|
|
|
2007-02-23 |
2007-02-22 |
V
Vente
|
FREIMAN PAUL E
President and CEO
Administrateur exécutif
|
64 563
-39.1%
2,61
168 535 USD
|
64 563
-39.1%
|
2,61
|
168 535 USD
|
|
|
2007-02-23 |
2007-02-21 |
V
Vente
|
FREIMAN PAUL E
President and CEO
Administrateur exécutif
|
10 437
-15.8%
2,73
28 474 USD
|
10 437
-15.8%
|
2,73
|
28 474 USD
|
|
|
2007-02-23 |
2007-02-21 |
V
Vente
|
FREIMAN PAUL E
President and CEO
Administrateur exécutif
|
25 000
-31.0%
2,73
68 205 USD
|
25 000
-31.0%
|
2,73
|
68 205 USD
|
|
|
2007-02-15 |
2007-02-14 |
V
Vente
|
ELIOT THEODORE
Administrateur non-exécutif
|
19 300
-51.3%
2,65
51 145 USD
|
19 300
-51.3%
|
2,65
|
51 145 USD
|
|
