|
2023-09-12 |
2023-09-12 |
VP
Vente planifiée
|
Perkins Adelene Q
Administrateur non-exécutif
|
410 196
-25.9%
0,07
28 714 USD
|
410 196
-25.9%
|
0,07
|
28 714 USD
|
|
|
2021-02-16 |
2021-02-11 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
152 127
-22.1%
5,37
816 709 USD
|
152 127
-22.1%
|
5,37
|
816 709 USD
|
|
|
2021-02-16 |
2021-02-11 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
892 467
-21.4%
5,37
4 791 298 USD
|
892 467
-21.4%
|
5,37
|
4 791 298 USD
|
|
|
2021-02-16 |
2021-02-11 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 215 491
-21.5%
5,37
6 525 485 USD
|
1 215 491
-21.5%
|
5,37
|
6 525 485 USD
|
|
|
2021-01-26 |
2021-01-22 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
568 019
-45.3%
4,14
2 350 917 USD
|
568 019
-45.3%
|
4,14
|
2 350 917 USD
|
|
|
2021-01-26 |
2021-01-22 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
2 458 838
-37.1%
4,14
10 176 639 USD
|
2 458 838
-37.1%
|
4,14
|
10 176 639 USD
|
|
|
2021-01-26 |
2021-01-22 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
2 821 663
-33.3%
4,14
11 678 299 USD
|
2 821 663
-33.3%
|
4,14
|
11 678 299 USD
|
|
|
2018-12-17 |
2018-12-13 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
120 539
+1.9%
1,20
144 587 USD
|
120 539
+1.9%
|
1,20
|
144 587 USD
|
|
|
2018-12-17 |
2018-12-13 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
54 461
+0.6%
1,20
65 326 USD
|
54 461
+0.6%
|
1,20
|
65 326 USD
|
|
|
2018-11-30 |
2018-11-28 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
100 000
+1.6%
1,30
130 000 USD
|
100 000
+1.6%
|
1,30
|
130 000 USD
|
|
|
2018-11-21 |
2018-11-21 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
581
+0.0%
1,35
784 USD
|
581
+0.0%
|
1,35
|
784 USD
|
|
|
2018-11-21 |
2018-11-21 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
4 119
+0.0%
1,35
5 561 USD
|
4 119
+0.0%
|
1,35
|
5 561 USD
|
|
|
2018-11-21 |
2018-11-19 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
5 573
+0.4%
1,35
7 524 USD
|
5 573
+0.4%
|
1,35
|
7 524 USD
|
|
|
2018-11-21 |
2018-11-19 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
38 001
+0.6%
1,35
51 301 USD
|
38 001
+0.6%
|
1,35
|
51 301 USD
|
|
|
2018-11-21 |
2018-11-19 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
50 044
+0.6%
1,35
67 559 USD
|
50 044
+0.6%
|
1,35
|
67 559 USD
|
|
|
2018-11-21 |
2018-11-19 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
81 648
+7.0%
1,37
111 841 USD
|
81 648
+7.0%
|
1,37
|
111 841 USD
|
|
|
2018-11-21 |
2018-11-19 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
556 709
+9.6%
1,37
762 580 USD
|
556 709
+9.6%
|
1,37
|
762 580 USD
|
|
|
2018-11-21 |
2018-11-19 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
733 151
+9.6%
1,37
1 004 270 USD
|
733 151
+9.6%
|
1,37
|
1 004 270 USD
|
|
|
2018-11-15 |
2018-11-15 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
39 074
+0.7%
1,35
52 750 USD
|
39 074
+0.7%
|
1,35
|
52 750 USD
|
|
|
2018-11-15 |
2018-11-15 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
52 400
+0.7%
1,35
70 740 USD
|
52 400
+0.7%
|
1,35
|
70 740 USD
|
|
|
2018-11-15 |
2018-11-14 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
92 960
+1.6%
1,34
124 566 USD
|
92 960
+1.6%
|
1,34
|
124 566 USD
|
|
|
2018-11-15 |
2018-11-14 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
117 290
+1.6%
1,34
157 169 USD
|
117 290
+1.6%
|
1,34
|
157 169 USD
|
|
|
2018-11-15 |
2018-11-13 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
562 754
+11.0%
1,35
759 718 USD
|
562 754
+11.0%
|
1,35
|
759 718 USD
|
|
|
2018-11-15 |
2018-11-13 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
41 454
+0.6%
1,35
55 963 USD
|
41 454
+0.6%
|
1,35
|
55 963 USD
|
|
|
2018-10-02 |
2018-10-01 |
VP
Vente planifiée
|
Perkins Adelene Q
Chief Executive Officer
Administrateur exécutif
|
5 000
-0.8%
2,82
14 100 USD
|
5 000
-0.8%
|
2,82
|
14 100 USD
|
|
|
2018-08-17 |
2018-08-16 |
VP
Vente planifiée
|
Kutok Jeffery
Chief Scientific Officer
Dirigeant
|
6 133
-100.0%
2,00
12 266 USD
|
6 133
-100.0%
|
2,00
|
12 266 USD
|
|
|
2018-08-17 |
2018-08-15 |
VP
Vente planifiée
|
Kutok Jeffery
Chief Scientific Officer
Dirigeant
|
8 180
-57.2%
2,01
16 421 USD
|
8 180
-57.2%
|
2,01
|
16 421 USD
|
|
|
2018-06-25 |
2018-06-22 |
VP
Vente planifiée
|
Kutok Jeffery
Chief Scientific Officer
|
14 313
-50.0%
2,00
28 695 USD
|
14 313
-50.0%
|
2,00
|
28 695 USD
|
|
|
2018-06-21 |
2018-06-21 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
36 825
+3.3%
1,65
60 761 USD
|
36 825
+3.3%
|
1,65
|
60 761 USD
|
|
|
2018-06-21 |
2018-06-21 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
158 151
+3.2%
1,65
260 949 USD
|
158 151
+3.2%
|
1,65
|
260 949 USD
|
|
|
2018-06-21 |
2018-06-21 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
230 555
+3.2%
1,65
380 416 USD
|
230 555
+3.2%
|
1,65
|
380 416 USD
|
|
|
2018-06-21 |
2018-06-19 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
179 893
+18.9%
1,65
296 823 USD
|
179 893
+18.9%
|
1,65
|
296 823 USD
|
|
|
2018-06-21 |
2018-06-19 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 419 907
+40.1%
1,65
2 342 847 USD
|
1 419 907
+40.1%
|
1,65
|
2 342 847 USD
|
|
|
2018-06-21 |
2018-06-19 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 916 760
+36.3%
1,65
3 162 654 USD
|
1 916 760
+36.3%
|
1,65
|
3 162 654 USD
|
|
|
2018-04-11 |
2018-04-10 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
97 453
+11.4%
2,00
194 906 USD
|
97 453
+11.4%
|
2,00
|
194 906 USD
|
|
|
2018-04-11 |
2018-04-10 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
365 682
+11.5%
2,00
731 364 USD
|
365 682
+11.5%
|
2,00
|
731 364 USD
|
|
|
2018-04-11 |
2018-04-10 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
546 865
+11.5%
2,00
1 093 730 USD
|
546 865
+11.5%
|
2,00
|
1 093 730 USD
|
|
|
2018-04-11 |
2018-04-09 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
62 437
+7.9%
1,90
118 630 USD
|
62 437
+7.9%
|
1,90
|
118 630 USD
|
|
|
2018-04-11 |
2018-04-09 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
208 872
+7.0%
1,90
396 857 USD
|
208 872
+7.0%
|
1,90
|
396 857 USD
|
|
|
2018-04-11 |
2018-04-09 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
228 691
+5.1%
1,90
434 513 USD
|
228 691
+5.1%
|
1,90
|
434 513 USD
|
|
|
2018-03-07 |
2018-03-05 |
VP
Vente planifiée
|
Perkins Adelene Q
Chief Executive Officer
Administrateur exécutif
|
5 000
-0.8%
2,78
13 890 USD
|
5 000
-0.8%
|
2,78
|
13 890 USD
|
|
|
2017-12-07 |
2017-12-06 |
A
Achat
|
BLOCH LAWRENCE E
President
|
500 000
+617.7%
1,81
905 000 USD
|
500 000
+617.7%
|
1,81
|
905 000 USD
|
|
|
2017-10-05 |
2017-10-04 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
63 042
+8.7%
1,28
80 946 USD
|
63 042
+8.7%
|
1,28
|
80 946 USD
|
|
|
2017-10-05 |
2017-10-04 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
235 326
+8.6%
1,28
302 159 USD
|
235 326
+8.6%
|
1,28
|
302 159 USD
|
|
|
2017-10-05 |
2017-10-04 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
355 081
+8.5%
1,28
455 924 USD
|
355 081
+8.5%
|
1,28
|
455 924 USD
|
|
|
2017-10-05 |
2017-10-03 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
28 918
+4.1%
1,24
35 714 USD
|
28 918
+4.1%
|
1,24
|
35 714 USD
|
|
|
2017-10-05 |
2017-10-03 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
394 078
+16.8%
1,24
486 686 USD
|
394 078
+16.8%
|
1,24
|
486 686 USD
|
|
|
2017-10-05 |
2017-10-03 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
523 601
+14.4%
1,24
646 647 USD
|
523 601
+14.4%
|
1,24
|
646 647 USD
|
|
|
2017-03-20 |
2017-03-17 |
V
Vente
|
VENUTI MICHAEL C
Administrateur non-exécutif
|
6 250
-11.1%
3,48
21 750 USD
|
6 250
-11.1%
|
3,48
|
21 750 USD
|
|
|
2017-01-05 |
2017-01-03 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
3 234
+0.1%
1,34
4 333 USD
|
3 234
+0.1%
|
1,34
|
4 333 USD
|
|
|
2017-01-05 |
2017-01-03 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 145
+0.0%
1,34
1 534 USD
|
1 145
+0.0%
|
1,34
|
1 534 USD
|
|
|
2016-12-30 |
2016-12-30 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 205
+0.1%
1,34
1 614 USD
|
1 205
+0.1%
|
1,34
|
1 614 USD
|
|
|
2016-12-30 |
2016-12-30 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
2 348
+0.1%
1,34
3 145 USD
|
2 348
+0.1%
|
1,34
|
3 145 USD
|
|
|
2016-12-30 |
2016-12-28 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
77 076
+12.4%
1,34
102 943 USD
|
77 076
+12.4%
|
1,34
|
102 943 USD
|
|
|
2016-12-30 |
2016-12-28 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
260 046
+12.5%
1,34
347 317 USD
|
260 046
+12.5%
|
1,34
|
347 317 USD
|
|
|
2016-12-30 |
2016-12-28 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
401 726
+12.5%
1,34
536 545 USD
|
401 726
+12.5%
|
1,34
|
536 545 USD
|
|
|
2016-12-20 |
2016-12-20 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
2 244
+0.4%
1,35
3 040 USD
|
2 244
+0.4%
|
1,35
|
3 040 USD
|
|
|
2016-12-20 |
2016-12-20 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
8 111
+0.4%
1,35
10 990 USD
|
8 111
+0.4%
|
1,35
|
10 990 USD
|
|
|
2016-12-20 |
2016-12-20 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
11 646
+0.4%
1,35
15 779 USD
|
11 646
+0.4%
|
1,35
|
15 779 USD
|
|
|
2016-12-20 |
2016-12-19 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
21 021
+3.5%
1,36
28 555 USD
|
21 021
+3.5%
|
1,36
|
28 555 USD
|
|
|
2016-12-20 |
2016-12-19 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
69 041
+3.5%
1,36
93 785 USD
|
69 041
+3.5%
|
1,36
|
93 785 USD
|
|
|
2016-12-20 |
2016-12-19 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
108 202
+3.5%
1,36
146 982 USD
|
108 202
+3.5%
|
1,36
|
146 982 USD
|
|
|
2016-12-20 |
2016-12-16 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
47 812
+8.7%
1,28
61 199 USD
|
47 812
+8.7%
|
1,28
|
61 199 USD
|
|
|
2016-12-20 |
2016-12-16 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
150 451
+8.1%
1,28
192 577 USD
|
150 451
+8.1%
|
1,28
|
192 577 USD
|
|
|
2016-12-20 |
2016-12-16 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
236 393
+8.2%
1,28
302 583 USD
|
236 393
+8.2%
|
1,28
|
302 583 USD
|
|
|
2016-12-14 |
2016-12-13 |
V
Vente
|
KANGO SUJAY
Chief Commercial Officer
Dirigeant
|
7 676
-92.8%
1,25
9 623 USD
|
7 676
-92.8%
|
1,25
|
9 623 USD
|
|
|
2016-12-14 |
2016-12-13 |
V
Vente
|
KANGO SUJAY
Chief Commercial Officer
Dirigeant
|
42 017
-83.5%
1,27
53 248 USD
|
42 017
-83.5%
|
1,27
|
53 248 USD
|
|
|
2016-12-14 |
2016-12-13 |
V
Vente
|
KANGO SUJAY
Chief Commercial Officer
Dirigeant
|
298
-0.6%
1,30
387 USD
|
298
-0.6%
|
1,30
|
387 USD
|
|
|
2016-12-14 |
2016-12-12 |
V
Vente
|
KANGO SUJAY
Chief Commercial Officer
Dirigeant
|
25 009
-33.1%
1,30
32 612 USD
|
25 009
-33.1%
|
1,30
|
32 612 USD
|
|
|
2016-12-02 |
2016-12-02 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
2 916
+0.5%
1,19
3 470 USD
|
2 916
+0.5%
|
1,19
|
3 470 USD
|
|
|
2016-12-02 |
2016-12-02 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
18 586
+1.0%
1,19
22 119 USD
|
18 586
+1.0%
|
1,19
|
22 119 USD
|
|
|
2016-12-02 |
2016-12-02 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
30 998
+1.1%
1,19
36 891 USD
|
30 998
+1.1%
|
1,19
|
36 891 USD
|
|
|
2016-12-02 |
2016-12-01 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
15 161
+2.8%
1,18
17 958 USD
|
15 161
+2.8%
|
1,18
|
17 958 USD
|
|
|
2016-12-02 |
2016-12-01 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
52 457
+3.0%
1,18
62 135 USD
|
52 457
+3.0%
|
1,18
|
62 135 USD
|
|
|
2016-12-02 |
2016-12-01 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
81 276
+2.9%
1,18
96 271 USD
|
81 276
+2.9%
|
1,18
|
96 271 USD
|
|
