|
2020-11-13 |
2020-11-11 |
VP
Vente planifiée
|
RINGO WILLIAM R
Administrateur non-exécutif
|
26 000
-72.2%
22,50
585 000 USD
|
26 000
-72.2%
|
22,50
|
585 000 USD
|
|
|
2020-11-13 |
2020-11-11 |
VP
Vente planifiée
|
RINGO WILLIAM R
Administrateur non-exécutif
|
52 959
-84.1%
22,50
1 191 578 USD
|
52 959
-84.1%
|
22,50
|
1 191 578 USD
|
|
|
2020-11-13 |
2020-11-11 |
V
Vente
|
BVF PARTNERS L P/IL
|
502 649
-86.1%
20,19
10 146 825 USD
|
502 649
-86.1%
|
20,19
|
10 146 825 USD
|
|
|
2020-11-13 |
2020-11-11 |
V
Vente
|
BVF PARTNERS L P/IL
|
2 949 477
-85.9%
20,19
59 540 207 USD
|
2 949 477
-85.9%
|
20,19
|
59 540 207 USD
|
|
|
2020-11-13 |
2020-11-11 |
V
Vente
|
BVF PARTNERS L P/IL
|
3 941 214
-85.5%
20,19
79 560 105 USD
|
3 941 214
-85.5%
|
20,19
|
79 560 105 USD
|
|
|
2020-11-06 |
2020-11-06 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
2 334
+0.4%
4,98
11 633 USD
|
2 334
+0.4%
|
4,98
|
11 633 USD
|
|
|
2020-11-06 |
2020-11-06 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
10 436
+0.3%
4,98
52 013 USD
|
10 436
+0.3%
|
4,98
|
52 013 USD
|
|
|
2020-11-06 |
2020-11-06 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
17 230
+0.4%
4,98
85 874 USD
|
17 230
+0.4%
|
4,98
|
85 874 USD
|
|
|
2020-11-06 |
2020-11-04 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
15 355
+2.7%
4,88
74 997 USD
|
15 355
+2.7%
|
4,88
|
74 997 USD
|
|
|
2020-11-06 |
2020-11-04 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
143 403
+4.4%
4,88
700 409 USD
|
143 403
+4.4%
|
4,88
|
700 409 USD
|
|
|
2020-11-06 |
2020-11-04 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
257 804
+5.9%
4,88
1 259 166 USD
|
257 804
+5.9%
|
4,88
|
1 259 166 USD
|
|
|
2020-10-08 |
2020-10-06 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
25 107
+4.6%
5,04
126 414 USD
|
25 107
+4.6%
|
5,04
|
126 414 USD
|
|
|
2020-10-08 |
2020-10-06 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
162 352
+5.2%
5,04
817 442 USD
|
162 352
+5.2%
|
5,04
|
817 442 USD
|
|
|
2020-10-08 |
2020-10-06 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
157 782
+3.8%
5,04
794 432 USD
|
157 782
+3.8%
|
5,04
|
794 432 USD
|
|
|
2020-09-24 |
2020-09-22 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
32
+0.0%
3,80
122 USD
|
32
+0.0%
|
3,80
|
122 USD
|
|
|
2020-05-18 |
2020-05-14 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
4 476
+0.8%
4,10
18 352 USD
|
4 476
+0.8%
|
4,10
|
18 352 USD
|
|
|
2020-05-18 |
2020-05-14 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
39 810
+1.3%
4,10
163 221 USD
|
39 810
+1.3%
|
4,10
|
163 221 USD
|
|
|
2020-05-18 |
2020-05-14 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
249 301
+6.3%
4,10
1 022 134 USD
|
249 301
+6.3%
|
4,10
|
1 022 134 USD
|
|
|
2019-12-26 |
2019-12-20 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
32 606
+6.5%
4,05
132 054 USD
|
32 606
+6.5%
|
4,05
|
132 054 USD
|
|
|
2019-12-26 |
2019-12-20 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
201 096
+7.0%
4,05
814 439 USD
|
201 096
+7.0%
|
4,05
|
814 439 USD
|
|
|
2019-12-26 |
2019-12-20 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
281 318
+7.7%
4,05
1 139 338 USD
|
281 318
+7.7%
|
4,05
|
1 139 338 USD
|
|
|
2019-12-11 |
2019-12-09 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
2 397
+0.5%
4,02
9 630 USD
|
2 397
+0.5%
|
4,02
|
9 630 USD
|
|
|
2019-12-11 |
2019-12-09 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
18 729
+0.7%
4,02
75 244 USD
|
18 729
+0.7%
|
4,02
|
75 244 USD
|
|
|
2019-12-11 |
2019-12-09 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
113 874
+3.2%
4,02
457 489 USD
|
113 874
+3.2%
|
4,02
|
457 489 USD
|
|
|
2019-12-04 |
2019-12-03 |
V
Vente
|
BERGER FRANKLIN M
Administrateur non-exécutif
|
47 890
-90.5%
4,00
191 560 USD
|
47 890
-90.5%
|
4,00
|
191 560 USD
|
|
|
2019-12-04 |
2019-12-02 |
V
Vente
|
BERGER FRANKLIN M
Administrateur non-exécutif
|
32 090
-37.8%
3,92
125 793 USD
|
32 090
-37.8%
|
3,92
|
125 793 USD
|
|
|
2019-11-26 |
2019-11-22 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
81 857
+19.5%
3,40
278 322 USD
|
81 857
+19.5%
|
3,40
|
278 322 USD
|
|
|
2019-11-26 |
2019-11-22 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
462 056
+19.3%
3,40
1 571 037 USD
|
462 056
+19.3%
|
3,40
|
1 571 037 USD
|
|
|
2019-11-26 |
2019-11-22 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
576 097
+19.5%
3,40
1 958 787 USD
|
576 097
+19.5%
|
3,40
|
1 958 787 USD
|
|
|
2019-11-07 |
2019-11-05 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
70 921
+20.3%
4,00
283 684 USD
|
70 921
+20.3%
|
4,00
|
283 684 USD
|
|
|
2019-11-07 |
2019-11-05 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
400 470
+20.1%
4,00
1 601 880 USD
|
400 470
+20.1%
|
4,00
|
1 601 880 USD
|
|
|
2019-11-07 |
2019-11-05 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
496 721
+20.2%
4,00
1 986 884 USD
|
496 721
+20.2%
|
4,00
|
1 986 884 USD
|
|
|
2019-10-31 |
2019-10-31 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
504
+0.1%
3,85
1 940 USD
|
504
+0.1%
|
3,85
|
1 940 USD
|
|
|
2019-10-31 |
2019-10-31 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
2 913
+0.1%
3,85
11 214 USD
|
2 913
+0.1%
|
3,85
|
11 214 USD
|
|
|
2019-10-31 |
2019-10-31 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
3 416
+0.1%
3,85
13 150 USD
|
3 416
+0.1%
|
3,85
|
13 150 USD
|
|
|
2019-10-31 |
2019-10-30 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 456
+0.4%
3,89
5 667 USD
|
1 456
+0.4%
|
3,89
|
5 667 USD
|
|
|
2019-10-31 |
2019-10-30 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
8 236
+0.4%
3,89
32 055 USD
|
8 236
+0.4%
|
3,89
|
32 055 USD
|
|
|
2019-10-31 |
2019-10-30 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
10 389
+0.4%
3,89
40 435 USD
|
10 389
+0.4%
|
3,89
|
40 435 USD
|
|
|
2019-10-31 |
2019-10-29 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
240
+0.1%
3,90
935 USD
|
240
+0.1%
|
3,90
|
935 USD
|
|
|
2019-10-31 |
2019-10-29 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 133
+0.1%
3,90
4 415 USD
|
1 133
+0.1%
|
3,90
|
4 415 USD
|
|
|
2019-10-31 |
2019-10-29 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 027
+0.0%
3,90
4 002 USD
|
1 027
+0.0%
|
3,90
|
4 002 USD
|
|
|
2019-10-25 |
2019-10-25 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
2 155
+0.6%
3,75
8 075 USD
|
2 155
+0.6%
|
3,75
|
8 075 USD
|
|
|
2019-10-25 |
2019-10-25 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
12 899
+0.7%
3,75
48 336 USD
|
12 899
+0.7%
|
3,75
|
48 336 USD
|
|
|
2019-10-25 |
2019-10-25 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
15 728
+0.6%
3,75
58 938 USD
|
15 728
+0.6%
|
3,75
|
58 938 USD
|
|
|
2019-10-25 |
2019-10-24 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 629
+0.5%
3,74
6 100 USD
|
1 629
+0.5%
|
3,74
|
6 100 USD
|
|
|
2019-10-25 |
2019-10-24 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
57 723
+3.0%
3,74
216 155 USD
|
57 723
+3.0%
|
3,74
|
216 155 USD
|
|
|
2019-10-25 |
2019-10-24 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
76 036
+3.2%
3,74
284 732 USD
|
76 036
+3.2%
|
3,74
|
284 732 USD
|
|
|
2019-10-25 |
2019-10-23 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
3 200
+0.1%
3,75
11 986 USD
|
3 200
+0.1%
|
3,75
|
11 986 USD
|
|
|
2019-10-08 |
2019-10-08 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
4 689
+1.4%
3,68
17 270 USD
|
4 689
+1.4%
|
3,68
|
17 270 USD
|
|
|
2019-10-08 |
2019-10-08 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
24 716
+1.3%
3,68
91 029 USD
|
24 716
+1.3%
|
3,68
|
91 029 USD
|
|
|
2019-10-08 |
2019-10-08 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
31 007
+1.3%
3,68
114 199 USD
|
31 007
+1.3%
|
3,68
|
114 199 USD
|
|
|
2019-10-08 |
2019-10-07 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
24 425
+7.8%
3,75
91 594 USD
|
24 425
+7.8%
|
3,75
|
91 594 USD
|
|
|
2019-10-08 |
2019-10-07 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
14 242
+4.8%
3,75
53 382 USD
|
14 242
+4.8%
|
3,75
|
53 382 USD
|
|
|
2019-10-08 |
2019-10-07 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
138 609
+7.9%
3,75
519 784 USD
|
138 609
+7.9%
|
3,75
|
519 784 USD
|
|
|
2019-10-08 |
2019-10-07 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
80 821
+4.8%
3,75
302 933 USD
|
80 821
+4.8%
|
3,75
|
302 933 USD
|
|
|
2019-10-08 |
2019-10-07 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
168 640
+7.8%
3,75
632 400 USD
|
168 640
+7.8%
|
3,75
|
632 400 USD
|
|
|
2019-10-08 |
2019-10-07 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
98 333
+4.8%
3,75
368 572 USD
|
98 333
+4.8%
|
3,75
|
368 572 USD
|
|
|
2019-10-08 |
2019-10-04 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
991
+0.3%
3,74
3 704 USD
|
991
+0.3%
|
3,74
|
3 704 USD
|
|
|
2019-10-08 |
2019-10-04 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
7 314
+0.4%
3,74
27 336 USD
|
7 314
+0.4%
|
3,74
|
27 336 USD
|
|
|
2019-10-08 |
2019-10-04 |
A
Achat
|
BVF PARTNERS L P/IL
Actionnaire important
|
7 695
+0.4%
3,74
28 760 USD
|
7 695
+0.4%
|
3,74
|
28 760 USD
|
|
|
2017-11-02 |
2017-11-01 |
VP
Vente planifiée
|
RINGO WILLIAM R
|
600
-100.0%
45,33
27 198 USD
|
600
-100.0%
|
45,33
|
27 198 USD
|
|
|
2017-10-03 |
2017-10-02 |
VP
Vente planifiée
|
RINGO WILLIAM R
|
600
-100.0%
40,78
24 468 USD
|
600
-100.0%
|
40,78
|
24 468 USD
|
|
|
2017-10-03 |
2017-09-29 |
VP
Vente planifiée
|
RINGO WILLIAM R
|
1 200
-100.0%
40,00
48 000 USD
|
1 200
-100.0%
|
40,00
|
48 000 USD
|
|
|
2017-10-02 |
2017-09-28 |
VP
Vente planifiée
|
RINGO WILLIAM R
Administrateur non-exécutif
|
2 000
-100.0%
38,00
76 000 USD
|
2 000
-100.0%
|
38,00
|
76 000 USD
|
|
|
2017-03-01 |
2017-03-01 |
VP
Vente planifiée
|
RINGO WILLIAM R
Administrateur non-exécutif
|
500
-100.0%
46,73
23 365 USD
|
500
-100.0%
|
46,73
|
23 365 USD
|
|
|
2017-02-01 |
2017-02-01 |
VP
Vente planifiée
|
RINGO WILLIAM R
Administrateur non-exécutif
|
500
-100.0%
46,17
23 085 USD
|
500
-100.0%
|
46,17
|
23 085 USD
|
|
|
2017-01-18 |
2017-01-18 |
VP
Vente planifiée
|
Sarena Francis Willard
Chief Strategy Officer
Dirigeant
|
3 636
-4.4%
47,39
172 310 USD
|
3 636
-4.4%
|
47,39
|
172 310 USD
|
|
|
2017-01-03 |
2017-01-03 |
VP
Vente planifiée
|
RINGO WILLIAM R
Administrateur non-exécutif
|
500
-100.0%
51,07
25 535 USD
|
500
-100.0%
|
51,07
|
25 535 USD
|
|
|
2016-12-23 |
2016-12-23 |
VP
Vente planifiée
|
Williams Lewis T
President, CEO and Chairman
Administrateur exécutif
|
300
-0.1%
51,02
15 306 USD
|
300
-0.1%
|
51,02
|
15 306 USD
|
|
|
2016-12-23 |
2016-12-23 |
VP
Vente planifiée
|
Williams Lewis T
President, CEO and Chairman
Administrateur exécutif
|
29 700
-6.4%
50,49
1 499 553 USD
|
29 700
-6.4%
|
50,49
|
1 499 553 USD
|
|
|
2016-12-02 |
2016-12-01 |
VP
Vente planifiée
|
RINGO WILLIAM R
Administrateur non-exécutif
|
500
-100.0%
57,72
28 860 USD
|
500
-100.0%
|
57,72
|
28 860 USD
|
|
|
2016-11-30 |
2016-11-28 |
VP
Vente planifiée
|
Sarena Francis Willard
Chief Strategy Officer
Dirigeant
|
1 710
-2.1%
60,14
102 839 USD
|
1 710
-2.1%
|
60,14
|
102 839 USD
|
|
|
2016-11-28 |
2016-11-25 |
VP
Vente planifiée
|
Sarena Francis Willard
Chief Strategy Officer
Dirigeant
|
21 189
-20.7%
60,48
1 281 511 USD
|
21 189
-20.7%
|
60,48
|
1 281 511 USD
|
|
|
2016-11-28 |
2016-11-23 |
VP
Vente planifiée
|
Sarena Francis Willard
Chief Strategy Officer
Dirigeant
|
13 465
-14.2%
60,23
810 997 USD
|
13 465
-14.2%
|
60,23
|
810 997 USD
|
|
|
2016-11-10 |
2016-11-09 |
VP
Vente planifiée
|
Jensen Peder
Administrateur non-exécutif
|
8 130
-100.0%
55,30
449 589 USD
|
8 130
-100.0%
|
55,30
|
449 589 USD
|
|
