|
2019-07-01 |
2019-06-27 |
A
Achat
|
Nussbaum Ran
|
36 923
+inf%
9,75
359 999 USD
|
36 923
+inf%
|
9,75
|
359 999 USD
|
|
|
2019-07-01 |
2019-06-27 |
A
Achat
|
Nussbaum Ran
|
72 205
+4.0%
9,75
703 999 USD
|
72 205
+4.0%
|
9,75
|
703 999 USD
|
|
|
2019-07-01 |
2019-06-27 |
A
Achat
|
Nussbaum Ran
|
65 016
+4.0%
9,75
633 906 USD
|
65 016
+4.0%
|
9,75
|
633 906 USD
|
|
|
2019-07-01 |
2019-06-27 |
A
Achat
|
Nussbaum Ran
|
133 548
+4.0%
9,75
1 302 093 USD
|
133 548
+4.0%
|
9,75
|
1 302 093 USD
|
|
|
2018-10-22 |
2018-07-13 |
A
Achat
|
Nussbaum Ran
Administrateur non-exécutif
|
43 657
+2.8%
5,50
240 114 USD
|
43 657
+2.8%
|
5,50
|
240 114 USD
|
|
|
2018-10-22 |
2018-07-13 |
A
Achat
|
Nussbaum Ran
Administrateur non-exécutif
|
89 676
+2.8%
5,50
493 218 USD
|
89 676
+2.8%
|
5,50
|
493 218 USD
|
|
|
2018-10-22 |
2018-07-13 |
A
Achat
|
Nussbaum Ran
Administrateur non-exécutif
|
48 485
+2.8%
5,50
266 668 USD
|
48 485
+2.8%
|
5,50
|
266 668 USD
|
|
|
2018-06-01 |
2018-05-30 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
175 813
-18.6%
5,00
879 083 USD
|
175 813
-18.6%
|
5,00
|
879 083 USD
|
|
|
2018-06-01 |
2018-05-30 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
312 266
-8.9%
5,00
1 561 361 USD
|
312 266
-8.9%
|
5,00
|
1 561 361 USD
|
|
|
2018-06-01 |
2018-05-30 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
547 860
-10.5%
5,00
2 739 355 USD
|
547 860
-10.5%
|
5,00
|
2 739 355 USD
|
|
|
2018-05-18 |
2018-05-18 |
A
Achat
|
Nussbaum Ran
Administrateur non-exécutif
|
8 611
+inf%
3,29
28 330 USD
|
8 611
+inf%
|
3,29
|
28 330 USD
|
|
|
2018-05-18 |
2018-05-18 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Dirigeant
|
15 000
+3.7%
3,39
50 849 USD
|
15 000
+3.7%
|
3,39
|
50 849 USD
|
|
|
2018-05-15 |
2018-05-14 |
A
Achat
|
ZENNER PATRICK J
Administrateur non-exécutif
|
8 446
+11.4%
2,96
24 987 USD
|
8 446
+11.4%
|
2,96
|
24 987 USD
|
|
|
2018-05-15 |
2018-05-11 |
A
Achat
|
LINDSAY RONALD M
Administrateur non-exécutif
|
6 900
+15.7%
2,69
18 589 USD
|
6 900
+15.7%
|
2,69
|
18 589 USD
|
|
|
2018-05-11 |
2018-05-10 |
A
Achat
|
LINDSAY RONALD M
Administrateur non-exécutif
|
23 900
+119.5%
2,67
63 837 USD
|
23 900
+119.5%
|
2,67
|
63 837 USD
|
|
|
2018-05-11 |
2018-05-10 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Dirigeant
|
1 300
+0.3%
2,64
3 427 USD
|
1 300
+0.3%
|
2,64
|
3 427 USD
|
|
|
2018-04-20 |
2018-04-18 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
217 256
-18.7%
3,10
673 494 USD
|
217 256
-18.7%
|
3,10
|
673 494 USD
|
|
|
2018-04-20 |
2018-04-18 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
808 449
-18.8%
3,10
2 506 192 USD
|
808 449
-18.8%
|
3,10
|
2 506 192 USD
|
|
|
2018-04-20 |
2018-04-18 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 204 668
-18.7%
3,10
3 734 471 USD
|
1 204 668
-18.7%
|
3,10
|
3 734 471 USD
|
|
|
2018-04-06 |
2018-04-04 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
214 336
-15.5%
2,90
621 574 USD
|
214 336
-15.5%
|
2,90
|
621 574 USD
|
|
|
2018-04-06 |
2018-04-04 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
817 611
-16.0%
2,90
2 371 072 USD
|
817 611
-16.0%
|
2,90
|
2 371 072 USD
|
|
|
2018-04-06 |
2018-04-04 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 269 634
-16.5%
2,90
3 681 939 USD
|
1 269 634
-16.5%
|
2,90
|
3 681 939 USD
|
|
|
2017-09-08 |
2017-09-07 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
|
1 101
+0.3%
1,15
1 261 USD
|
1 101
+0.3%
|
1,15
|
1 261 USD
|
|
|
2017-09-07 |
2017-09-06 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
|
16 397
+4.2%
1,15
18 840 USD
|
16 397
+4.2%
|
1,15
|
18 840 USD
|
|
|
2017-09-06 |
2017-09-05 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
|
19 156
+5.2%
1,14
21 844 USD
|
19 156
+5.2%
|
1,14
|
21 844 USD
|
|
|
2017-08-31 |
2017-08-29 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
|
300
+0.1%
1,05
315 USD
|
300
+0.1%
|
1,05
|
315 USD
|
|
|
2017-08-29 |
2017-08-28 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
|
2 970
+0.8%
1,05
3 115 USD
|
2 970
+0.8%
|
1,05
|
3 115 USD
|
|
|
2017-08-28 |
2017-08-25 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
|
701
+0.2%
1,05
736 USD
|
701
+0.2%
|
1,05
|
736 USD
|
|
|
2017-08-28 |
2017-08-24 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
|
8 791
+2.5%
1,05
9 212 USD
|
8 791
+2.5%
|
1,05
|
9 212 USD
|
|
|
2015-12-18 |
2015-12-17 |
A
Achat
|
LOBERG MICHAEL D
Administrateur non-exécutif
|
3 719
+2.9%
2,16
8 030 USD
|
3 719
+2.9%
|
2,16
|
8 030 USD
|
|
|
2015-12-17 |
2015-12-16 |
A
Achat
|
LOBERG MICHAEL D
Administrateur non-exécutif
|
1 231
+1.0%
2,14
2 633 USD
|
1 231
+1.0%
|
2,14
|
2 633 USD
|
|
|
2015-12-16 |
2015-12-15 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Dirigeant
|
1 283
+0.5%
2,16
2 771 USD
|
1 283
+0.5%
|
2,16
|
2 771 USD
|
|
|
2015-12-14 |
2015-12-11 |
A
Achat
|
ZENNER PATRICK J
Administrateur non-exécutif
|
2 300
+3.2%
2,15
4 947 USD
|
2 300
+3.2%
|
2,15
|
4 947 USD
|
|
|
2015-12-14 |
2015-12-11 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Dirigeant
|
1 108
+0.4%
2,10
2 324 USD
|
1 108
+0.4%
|
2,10
|
2 324 USD
|
|
|
2015-12-11 |
2015-12-10 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Dirigeant
|
6 600
+2.7%
2,10
13 844 USD
|
6 600
+2.7%
|
2,10
|
13 844 USD
|
|
|
2015-12-11 |
2015-12-09 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Dirigeant
|
1 009
+0.4%
2,10
2 119 USD
|
1 009
+0.4%
|
2,10
|
2 119 USD
|
|
|
2015-03-12 |
2015-03-11 |
A
Achat
|
ZENNER PATRICK J
Administrateur non-exécutif
|
10 625
+17.5%
2,32
24 647 USD
|
10 625
+17.5%
|
2,32
|
24 647 USD
|
|
|
2014-11-20 |
2014-11-20 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Dirigeant
|
5 000
+2.1%
1,26
6 298 USD
|
5 000
+2.1%
|
1,26
|
6 298 USD
|
|
|
2014-11-18 |
2014-11-14 |
A
Achat
|
Messenger William G
Administrateur non-exécutif
|
8 500
+566.7%
1,21
10 284 USD
|
8 500
+566.7%
|
1,21
|
10 284 USD
|
|
|
2014-11-17 |
2014-11-14 |
A
Achat
|
ZENNER PATRICK J
Administrateur non-exécutif
|
20 830
+52.1%
1,20
24 952 USD
|
20 830
+52.1%
|
1,20
|
24 952 USD
|
|
|
2014-11-17 |
2014-11-13 |
A
Achat
|
Kelley Susan L.
Administrateur non-exécutif
|
50 000
+inf%
1,20
60 160 USD
|
50 000
+inf%
|
1,20
|
60 160 USD
|
|
|
2014-09-05 |
2014-09-04 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Dirigeant
|
5 000
+2.1%
1,31
6 525 USD
|
5 000
+2.1%
|
1,31
|
6 525 USD
|
|
|
2014-05-27 |
2014-05-23 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Dirigeant
|
5 000
+2.2%
1,40
7 011 USD
|
5 000
+2.2%
|
1,40
|
7 011 USD
|
|
|
2014-05-21 |
2014-05-20 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Dirigeant
|
5 000
+2.2%
1,42
7 124 USD
|
5 000
+2.2%
|
1,42
|
7 124 USD
|
|
|
2014-03-19 |
2014-03-17 |
A
Achat
|
ZENNER PATRICK J
Administrateur non-exécutif
|
4 715
+13.4%
2,12
10 009 USD
|
4 715
+13.4%
|
2,12
|
10 009 USD
|
|
|
2014-03-14 |
2014-03-13 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Dirigeant
|
10 000
+4.6%
2,10
20 990 USD
|
10 000
+4.6%
|
2,10
|
20 990 USD
|
|
|
2012-06-14 |
2012-06-12 |
A
Achat
|
ZENNER PATRICK J
Administrateur non-exécutif
|
4 000
+12.8%
6,47
25 871 USD
|
4 000
+12.8%
|
6,47
|
25 871 USD
|
|
|
2012-06-07 |
2012-06-06 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Dirigeant
|
4 754
+2.2%
6,24
29 684 USD
|
4 754
+2.2%
|
6,24
|
29 684 USD
|
|
|
2012-06-07 |
2012-06-06 |
A
Achat
|
Lawrence Peter S
President & COO
Dirigeant
|
1 000
+1.4%
6,25
6 254 USD
|
1 000
+1.4%
|
6,25
|
6 254 USD
|
|
|
2012-06-07 |
2012-06-06 |
A
Achat
|
SCHWARTZ BRIAN
Chief Medical Officer
Dirigeant
|
4 700
+20.0%
6,26
29 412 USD
|
4 700
+20.0%
|
6,26
|
29 412 USD
|
|
|
2011-12-05 |
2011-12-02 |
A
Achat
|
ZENNER PATRICK J
Administrateur non-exécutif
|
4 400
+16.4%
5,53
24 321 USD
|
4 400
+16.4%
|
5,53
|
24 321 USD
|
|
|
2011-09-01 |
2011-08-31 |
A
Achat
|
SCHWARTZ BRIAN
Chief Medical Officer
Dirigeant
|
4 000
+19.4%
4,41
17 621 USD
|
4 000
+19.4%
|
4,41
|
17 621 USD
|
|
|
2011-08-24 |
2011-08-24 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Administrateur exécutif
|
6 600
+3.2%
4,45
29 376 USD
|
6 600
+3.2%
|
4,45
|
29 376 USD
|
|
|
2011-06-09 |
2011-06-07 |
A
Achat
|
LOBERG MICHAEL D
Administrateur non-exécutif
|
27 676
+68.0%
6,40
177 063 USD
|
27 676
+68.0%
|
6,40
|
177 063 USD
|
|
|
2011-05-26 |
2011-05-25 |
A
Achat
|
LOBERG MICHAEL D
Administrateur non-exécutif
|
1 398
+3.6%
6,32
8 838 USD
|
1 398
+3.6%
|
6,32
|
8 838 USD
|
|
|
2010-04-07 |
2010-04-05 |
V
Vente
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Actionnaire important
|
354 000
-7.8%
6,13
2 170 303 USD
|
354 000
-7.8%
|
6,13
|
2 170 303 USD
|
|
|
2010-04-07 |
2010-04-05 |
V
Vente
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Actionnaire important
|
102 000
-2.2%
6,13
625 342 USD
|
102 000
-2.2%
|
6,13
|
625 342 USD
|
|
|
2010-04-07 |
2010-04-05 |
V
Vente
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Actionnaire important
|
147 000
-3.1%
6,13
901 228 USD
|
147 000
-3.1%
|
6,13
|
901 228 USD
|
|
|
2010-04-02 |
2010-04-01 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
653 000
-12.0%
5,81
3 794 779 USD
|
653 000
-12.0%
|
5,81
|
3 794 779 USD
|
|
|
2010-04-02 |
2010-04-01 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
188 000
-3.3%
5,81
1 092 524 USD
|
188 000
-3.3%
|
5,81
|
1 092 524 USD
|
|
|
2010-04-02 |
2010-04-01 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
272 000
-4.6%
5,81
1 580 674 USD
|
272 000
-4.6%
|
5,81
|
1 580 674 USD
|
|
|
2010-04-02 |
2010-03-31 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
1 548 000
-20.7%
6,24
9 660 758 USD
|
1 548 000
-20.7%
|
6,24
|
9 660 758 USD
|
|
|
2010-04-02 |
2010-03-31 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
447 000
-5.6%
6,24
2 789 638 USD
|
447 000
-5.6%
|
6,24
|
2 789 638 USD
|
|
|
2010-04-02 |
2010-03-31 |
V
Vente
|
BVF PARTNERS L P/IL
Actionnaire important
|
645 000
-7.5%
6,24
4 025 316 USD
|
645 000
-7.5%
|
6,24
|
4 025 316 USD
|
|
|
2009-11-30 |
2009-11-25 |
A
Achat
|
ZENNER PATRICK J
Administrateur non-exécutif
|
6 900
+34.5%
3,58
24 734 USD
|
6 900
+34.5%
|
3,58
|
24 734 USD
|
|
|
2009-11-13 |
2009-11-12 |
A
Achat
|
Pucci Paolo
Chief Executive Officer
Administrateur exécutif
|
5 000
+2.4%
3,48
17 420 USD
|
5 000
+2.4%
|
3,48
|
17 420 USD
|
|
|
2009-09-21 |
2009-09-17 |
V
Vente
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Actionnaire important
|
2 100 000
-19.7%
5,25
11 025 000 USD
|
2 100 000
-19.7%
|
5,25
|
11 025 000 USD
|
|
|
2009-09-21 |
2009-09-17 |
V
Vente
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Actionnaire important
|
660 000
-5.8%
5,25
3 465 000 USD
|
660 000
-5.8%
|
5,25
|
3 465 000 USD
|
|
|
2009-09-21 |
2009-09-17 |
V
Vente
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Actionnaire important
|
920 000
-7.5%
5,25
4 830 000 USD
|
920 000
-7.5%
|
5,25
|
4 830 000 USD
|
|
|
2009-08-19 |
2009-08-18 |
A
Achat
|
BARABE TIMOTHY C
Administrateur non-exécutif
|
784
+3.1%
5,26
4 124 USD
|
784
+3.1%
|
5,26
|
4 124 USD
|
|
|
2009-08-19 |
2009-08-18 |
A
Achat
|
LOBERG MICHAEL D
Administrateur non-exécutif
|
356
+0.6%
5,26
1 873 USD
|
356
+0.6%
|
5,26
|
1 873 USD
|
|
|
2009-08-17 |
2009-08-13 |
A
Achat
|
LOBERG MICHAEL D
Administrateur non-exécutif
|
88
+0.1%
5,65
497 USD
|
88
+0.1%
|
5,65
|
497 USD
|
|
|
2009-08-06 |
2009-08-05 |
A
Achat
|
BARABE TIMOTHY C
Administrateur non-exécutif
|
104
+0.4%
5,73
596 USD
|
104
+0.4%
|
5,73
|
596 USD
|
|
|
2009-07-28 |
2009-07-24 |
A
Achat
|
BARABE TIMOTHY C
Administrateur non-exécutif
|
206
+0.8%
5,82
1 199 USD
|
206
+0.8%
|
5,82
|
1 199 USD
|
|
|
2009-07-28 |
2009-07-24 |
A
Achat
|
LOBERG MICHAEL D
Administrateur non-exécutif
|
171
+0.3%
5,82
995 USD
|
171
+0.3%
|
5,82
|
995 USD
|
|
