|
2019-02-01 |
2019-01-30 |
VP
Vente planifiée
|
AYRES JOHN C
SEE REMARKS
Dirigeant
|
3 125
-2.3%
4,19
13 094 USD
|
3 125
-2.3%
|
4,19
|
13 094 USD
|
|
|
2018-12-17 |
2018-12-17 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
46 094
-8.2%
5,85
269 788 USD
|
46 094
-8.2%
|
5,85
|
269 788 USD
|
|
|
2018-11-09 |
2018-11-07 |
VP
Vente planifiée
|
HEINEN ERNST
Chief Development Officer
Dirigeant
|
19 308
-12.5%
6,95
134 191 USD
|
19 308
-12.5%
|
6,95
|
134 191 USD
|
|
|
2018-11-06 |
2018-11-02 |
VP
Vente planifiée
|
HEINEN ERNST
Chief Development Officer
Dirigeant
|
692
-0.4%
6,95
4 809 USD
|
692
-0.4%
|
6,95
|
4 809 USD
|
|
|
2018-10-31 |
2018-10-30 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
11 513
-2.0%
5,86
67 454 USD
|
11 513
-2.0%
|
5,86
|
67 454 USD
|
|
|
2018-09-21 |
2018-09-21 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
75 000
-11.6%
6,06
454 305 USD
|
75 000
-11.6%
|
6,06
|
454 305 USD
|
|
|
2018-08-14 |
2018-08-14 |
VP
Vente planifiée
|
HEINEN ERNST
Chief Development Officer
Dirigeant
|
1 712
-1.1%
5,15
8 817 USD
|
1 712
-1.1%
|
5,15
|
8 817 USD
|
|
|
2018-08-14 |
2018-08-13 |
VP
Vente planifiée
|
HEINEN ERNST
Chief Development Officer
Dirigeant
|
8 660
-5.2%
5,15
44 599 USD
|
8 660
-5.2%
|
5,15
|
44 599 USD
|
|
|
2018-08-10 |
2018-08-10 |
VP
Vente planifiée
|
HEINEN ERNST
Chief Development Officer
Dirigeant
|
1 954
-1.2%
5,15
10 063 USD
|
1 954
-1.2%
|
5,15
|
10 063 USD
|
|
|
2018-08-10 |
2018-08-08 |
VP
Vente planifiée
|
HEINEN ERNST
Chief Development Officer
Dirigeant
|
2 674
-1.6%
5,15
13 771 USD
|
2 674
-1.6%
|
5,15
|
13 771 USD
|
|
|
2018-07-30 |
2018-07-30 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
11 513
-1.7%
4,33
49 842 USD
|
11 513
-1.7%
|
4,33
|
49 842 USD
|
|
|
2018-06-27 |
2018-06-25 |
VP
Vente planifiée
|
Standridge Brent
Chief Operating Officer
Dirigeant
|
10 000
-9.1%
4,56
45 644 USD
|
10 000
-9.1%
|
4,56
|
45 644 USD
|
|
|
2018-02-01 |
2018-01-30 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
19 367
-2.8%
4,77
92 301 USD
|
19 367
-2.8%
|
4,77
|
92 301 USD
|
|
|
2018-01-12 |
2018-01-11 |
VP
Vente planifiée
|
TOOMAN CRAIG A
CHIEF FINANCIAL OFFICER
Dirigeant
|
30 000
-28.6%
5,27
158 040 USD
|
30 000
-28.6%
|
5,27
|
158 040 USD
|
|
|
2017-12-01 |
2017-12-01 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
425 298
-9.0%
5,40
2 296 609 USD
|
425 298
-9.0%
|
5,40
|
2 296 609 USD
|
|
|
2017-12-01 |
2017-12-01 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
1 900
-0.0%
5,44
10 336 USD
|
1 900
-0.0%
|
5,44
|
10 336 USD
|
|
|
2017-12-01 |
2017-12-01 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
50 000
-1.0%
5,45
272 500 USD
|
50 000
-1.0%
|
5,45
|
272 500 USD
|
|
|
2017-12-01 |
2017-12-01 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
100
-0.0%
5,47
547 USD
|
100
-0.0%
|
5,47
|
547 USD
|
|
|
2017-12-01 |
2017-12-01 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
5 110
-0.1%
5,52
28 207 USD
|
5 110
-0.1%
|
5,52
|
28 207 USD
|
|
|
2017-12-01 |
2017-12-01 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
8 020
-0.2%
5,53
44 351 USD
|
8 020
-0.2%
|
5,53
|
44 351 USD
|
|
|
2017-12-01 |
2017-12-01 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
72 000
-1.5%
5,65
406 800 USD
|
72 000
-1.5%
|
5,65
|
406 800 USD
|
|
|
2017-12-01 |
2017-11-30 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
50 000
-1.0%
5,90
295 000 USD
|
50 000
-1.0%
|
5,90
|
295 000 USD
|
|
|
2017-12-01 |
2017-11-30 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
50 000
-1.0%
5,95
297 500 USD
|
50 000
-1.0%
|
5,95
|
297 500 USD
|
|
|
2017-12-01 |
2017-11-30 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
100 000
-2.0%
5,95
595 000 USD
|
100 000
-2.0%
|
5,95
|
595 000 USD
|
|
|
2017-12-01 |
2017-11-30 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
11 472
-0.2%
5,97
68 488 USD
|
11 472
-0.2%
|
5,97
|
68 488 USD
|
|
|
2017-12-01 |
2017-11-30 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
100
-0.0%
6,03
603 USD
|
100
-0.0%
|
6,03
|
603 USD
|
|
|
2017-12-01 |
2017-11-29 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
1 900
-0.0%
6,26
11 894 USD
|
1 900
-0.0%
|
6,26
|
11 894 USD
|
|
|
2017-12-01 |
2017-11-29 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
300
-0.0%
6,28
1 884 USD
|
300
-0.0%
|
6,28
|
1 884 USD
|
|
|
2017-12-01 |
2017-11-29 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
7 700
-0.2%
6,35
48 895 USD
|
7 700
-0.2%
|
6,35
|
48 895 USD
|
|
|
2017-12-01 |
2017-11-29 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
50 000
-1.0%
6,50
325 000 USD
|
50 000
-1.0%
|
6,50
|
325 000 USD
|
|
|
2017-12-01 |
2017-11-29 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
5 751
-0.1%
6,55
37 669 USD
|
5 751
-0.1%
|
6,55
|
37 669 USD
|
|
|
2017-12-01 |
2017-11-29 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
49 865
-1.0%
6,60
329 109 USD
|
49 865
-1.0%
|
6,60
|
329 109 USD
|
|
|
2017-12-01 |
2017-11-29 |
V
Vente
|
Broadfin Healthcare Master Fund Ltd
Actionnaire important
|
1 000
-0.0%
6,66
6 660 USD
|
1 000
-0.0%
|
6,66
|
6 660 USD
|
|
|
2017-11-13 |
2017-11-10 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
50 000
-8.6%
7,00
350 000 USD
|
50 000
-8.6%
|
7,00
|
350 000 USD
|
|
|
2017-10-04 |
2017-10-02 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
50 000
-7.9%
6,24
312 115 USD
|
50 000
-7.9%
|
6,24
|
312 115 USD
|
|
|
2017-09-27 |
2017-09-25 |
VP
Vente planifiée
|
Standridge Brent
Chief Operating Officer
|
10 000
-12.5%
6,11
61 127 USD
|
10 000
-12.5%
|
6,11
|
61 127 USD
|
|
|
2017-09-19 |
2017-09-15 |
VP
Vente planifiée
|
HEINEN ERNST
Chief Development Officer
|
10 000
-7.1%
6,25
62 500 USD
|
10 000
-7.1%
|
6,25
|
62 500 USD
|
|
|
2017-04-18 |
2017-04-17 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
50 000
-7.9%
5,54
277 150 USD
|
50 000
-7.9%
|
5,54
|
277 150 USD
|
|
|
2017-01-31 |
2017-01-27 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
50 000
-7.3%
7,72
385 875 USD
|
50 000
-7.3%
|
7,72
|
385 875 USD
|
|
|
2016-12-16 |
2016-12-15 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
50 000
-8.4%
7,63
381 380 USD
|
50 000
-8.4%
|
7,63
|
381 380 USD
|
|
|
2016-10-04 |
2016-10-03 |
VP
Vente planifiée
|
HEINEN ERNST
Chief Development Officer
Dirigeant
|
10 000
-8.0%
10,00
100 006 USD
|
10 000
-8.0%
|
10,00
|
100 006 USD
|
|
|
2016-09-12 |
2016-09-09 |
VP
Vente planifiée
|
TOOMAN CRAIG A
CHIEF FINANCIAL OFFICER
Dirigeant
|
30 000
-29.3%
9,25
277 599 USD
|
30 000
-29.3%
|
9,25
|
277 599 USD
|
|
|
2016-08-10 |
2016-08-09 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
50 000
-7.2%
9,25
462 500 USD
|
50 000
-7.2%
|
9,25
|
462 500 USD
|
|
|
2016-06-28 |
2016-06-28 |
VP
Vente planifiée
|
STEPHANUS JULIA A
CHIEF COMMERCIAL OFFICER
Dirigeant
|
30 000
-19.0%
6,25
187 500 USD
|
30 000
-19.0%
|
6,25
|
187 500 USD
|
|
|
2016-06-17 |
2016-06-17 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
25 000
-3.5%
6,32
158 020 USD
|
25 000
-3.5%
|
6,32
|
158 020 USD
|
|
|
2016-06-17 |
2016-06-16 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
75 000
-9.5%
6,24
468 293 USD
|
75 000
-9.5%
|
6,24
|
468 293 USD
|
|
|
2016-06-13 |
2016-06-10 |
VP
Vente planifiée
|
HEINEN ERNST
Chief Development Officer
Dirigeant
|
15 000
-10.7%
6,72
100 862 USD
|
15 000
-10.7%
|
6,72
|
100 862 USD
|
|
|
2016-02-02 |
2016-02-01 |
VP
Vente planifiée
|
TOOMAN CRAIG A
CHIEF FINANCIAL OFFICER
Dirigeant
|
2 806
-2.7%
3,36
9 436 USD
|
2 806
-2.7%
|
3,36
|
9 436 USD
|
|
|
2015-04-28 |
2015-04-27 |
VP
Vente planifiée
|
Rhodes Linda
CHIEF SCIENTIFIC OFFICER
Dirigeant
|
3 300
-0.8%
15,78
52 073 USD
|
3 300
-0.8%
|
15,78
|
52 073 USD
|
|
|
2015-04-28 |
2015-04-27 |
VP
Vente planifiée
|
Rhodes Linda
CHIEF SCIENTIFIC OFFICER
Dirigeant
|
11 700
-2.7%
14,78
172 912 USD
|
11 700
-2.7%
|
14,78
|
172 912 USD
|
|
|
2015-01-06 |
2015-01-02 |
VP
Vente planifiée
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
25 000
-3.5%
17,87
446 648 USD
|
25 000
-3.5%
|
17,87
|
446 648 USD
|
|
|
2014-03-12 |
2014-03-10 |
V
Vente
|
MPM BIOVENTURES V, L.P.
Actionnaire important
|
600 000
-17.9%
20,02
12 012 000 USD
|
600 000
-17.9%
|
20,02
|
12 012 000 USD
|
|
|
2014-03-11 |
2014-03-07 |
V
Vente
|
Foley Todd
Actionnaire important
|
12 539
-100.0%
19,95
250 153 USD
|
12 539
-100.0%
|
19,95
|
250 153 USD
|
|
|
2014-03-11 |
2014-03-07 |
V
Vente
|
GADICKE ANSBERT
Actionnaire important
|
26 713
-100.0%
20,16
538 534 USD
|
26 713
-100.0%
|
20,16
|
538 534 USD
|
|
|
2014-02-05 |
2014-02-03 |
V
Vente
|
MEEUSEN RONALD L
Administrateur non-exécutif
|
45 100
-37.4%
19,00
856 900 USD
|
45 100
-37.4%
|
19,00
|
856 900 USD
|
|
|
2014-02-05 |
2014-02-03 |
V
Vente
|
MEEUSEN RONALD L
Administrateur non-exécutif
|
454 900
-37.4%
19,00
8 643 100 USD
|
454 900
-37.4%
|
19,00
|
8 643 100 USD
|
|
|
2014-02-05 |
2014-02-03 |
V
Vente
|
Avalon Ventures IX, L.P.
Actionnaire important
|
825 000
-19.8%
19,00
15 675 000 USD
|
825 000
-19.8%
|
19,00
|
15 675 000 USD
|
|
|
2014-02-05 |
2014-02-03 |
V
Vente
|
Lichter Jay
Administrateur non-exécutif
Actionnaire important
|
825 000
-19.8%
19,00
15 675 000 USD
|
825 000
-19.8%
|
19,00
|
15 675 000 USD
|
|
|
2013-07-03 |
2013-07-02 |
A
Achat
|
St Peter Steven
PRESIDENT AND CEO
Administrateur exécutif
|
8 333
+1.6%
6,00
49 998 USD
|
8 333
+1.6%
|
6,00
|
49 998 USD
|
|
|
2013-07-03 |
2013-07-02 |
A
Achat
|
STEPHANUS JULIA A
CHIEF COMMERCIAL OFFICER
Dirigeant
|
2 000
+1.5%
6,00
12 000 USD
|
2 000
+1.5%
|
6,00
|
12 000 USD
|
|
|
2013-07-02 |
2013-07-02 |
A
Achat
|
Vander Vort John
Administrateur non-exécutif
Actionnaire important
|
500 000
+13.0%
6,00
3 000 000 USD
|
500 000
+13.0%
|
6,00
|
3 000 000 USD
|
|
|
2013-07-02 |
2013-07-02 |
A
Achat
|
MPM BIOVENTURES V, L.P.
Actionnaire important
|
500 000
+13.0%
6,00
3 000 000 USD
|
500 000
+13.0%
|
6,00
|
3 000 000 USD
|
|
