|
2017-09-20 |
2017-09-20 |
A
Achat
|
THOMPSON JOHN CRAIG
President & CEO
|
8 550
+75.7%
1,32
11 286 USD
|
8 550
+75.7%
|
1,32
|
11 286 USD
|
|
|
2017-09-07 |
2017-09-07 |
A
Achat
|
TRUEX PAUL F
|
5 000
+42.4%
1,34
6 700 USD
|
5 000
+42.4%
|
1,34
|
6 700 USD
|
|
|
2015-11-18 |
2015-11-13 |
VP
Vente planifiée
|
Hislop Colin
Chief Medical Officer
Dirigeant
|
12 500
-39.5%
5,31
66 341 USD
|
12 500
-39.5%
|
5,31
|
66 341 USD
|
|
|
2015-11-12 |
2015-11-11 |
V
Vente
|
Hislop Colin
Chief Medical Officer
Dirigeant
|
5 000
-20.7%
5,38
26 900 USD
|
5 000
-20.7%
|
5,38
|
26 900 USD
|
|
|
2013-06-26 |
2013-06-24 |
A
Achat
|
Thompson David E.
Administrateur non-exécutif
|
100 000
+354.6%
0,53
53 000 USD
|
100 000
+354.6%
|
0,53
|
53 000 USD
|
|
|
2013-06-04 |
2013-05-31 |
A
Achat
|
DZIURZYNSKI BOGDAN
Administrateur non-exécutif
|
10 000
+inf%
0,59
5 900 USD
|
10 000
+inf%
|
0,59
|
5 900 USD
|
|
|
2013-02-01 |
2013-01-30 |
A
Achat
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
|
5 700 000
+323.5%
0,66
3 762 000 USD
|
5 700 000
+323.5%
|
0,66
|
3 762 000 USD
|
|
|
2013-01-29 |
2013-01-25 |
A
Achat
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
|
1 762 000
+inf%
0,65
1 142 481 USD
|
1 762 000
+inf%
|
0,65
|
1 142 481 USD
|
|
|
2012-07-03 |
2012-06-29 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
|
1 283 300
-100.0%
0,73
942 071 USD
|
1 283 300
-100.0%
|
0,73
|
942 071 USD
|
|
|
2012-07-02 |
2012-06-29 |
A
Achat
|
HENNEY CHRISTOPHER S
Administrateur non-exécutif
|
100 000
+inf%
0,75
74 930 USD
|
100 000
+inf%
|
0,75
|
74 930 USD
|
|
|
2012-07-02 |
2012-06-29 |
A
Achat
|
HENNEY CHRISTOPHER S
Administrateur non-exécutif
|
100 000
+97.6%
0,75
74 930 USD
|
100 000
+97.6%
|
0,75
|
74 930 USD
|
|
|
2012-07-02 |
2012-06-29 |
A
Achat
|
TRUEX PAUL F
President and CEO
Administrateur exécutif
|
20 000
+3.2%
0,76
15 200 USD
|
20 000
+3.2%
|
0,76
|
15 200 USD
|
|
|
2012-03-22 |
2012-03-22 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
|
1 306 700
-50.5%
2,40
3 140 131 USD
|
1 306 700
-50.5%
|
2,40
|
3 140 131 USD
|
|
|
2012-03-22 |
2012-03-21 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
|
125 000
-4.6%
2,87
358 313 USD
|
125 000
-4.6%
|
2,87
|
358 313 USD
|
|
|
2012-03-22 |
2012-03-20 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
|
116 800
-4.1%
2,90
338 638 USD
|
116 800
-4.1%
|
2,90
|
338 638 USD
|
|
|
2012-01-03 |
2011-12-30 |
V
Vente
|
HEALY JAMES
Administrateur non-exécutif
Actionnaire important
|
280
-0.6%
6,23
1 743 USD
|
280
-0.6%
|
6,23
|
1 743 USD
|
|
|
2012-01-03 |
2011-12-30 |
V
Vente
|
HEALY JAMES
Administrateur non-exécutif
Actionnaire important
|
4 090
-0.6%
6,23
25 460 USD
|
4 090
-0.6%
|
6,23
|
25 460 USD
|
|
|
2012-01-03 |
2011-12-30 |
V
Vente
|
SOFINNOVA VENTURE PARTNERS VI L P
Actionnaire important
|
280
-0.6%
6,23
1 743 USD
|
280
-0.6%
|
6,23
|
1 743 USD
|
|
|
2012-01-03 |
2011-12-30 |
V
Vente
|
SOFINNOVA VENTURE PARTNERS VI L P
Actionnaire important
|
4 090
-0.6%
6,23
25 460 USD
|
4 090
-0.6%
|
6,23
|
25 460 USD
|
|
|
2012-01-03 |
2011-12-30 |
V
Vente
|
HEALY JAMES
Administrateur non-exécutif
Actionnaire important
|
20 630
-0.6%
6,23
128 422 USD
|
20 630
-0.6%
|
6,23
|
128 422 USD
|
|
|
2012-01-03 |
2011-12-30 |
V
Vente
|
SOFINNOVA VENTURE PARTNERS VI L P
Actionnaire important
|
20 630
-0.6%
6,23
128 422 USD
|
20 630
-0.6%
|
6,23
|
128 422 USD
|
|
|
2011-12-23 |
2011-12-22 |
V
Vente
|
HEALY JAMES
Administrateur non-exécutif
Actionnaire important
|
280
-0.6%
6,22
1 743 USD
|
280
-0.6%
|
6,22
|
1 743 USD
|
|
|
2011-12-23 |
2011-12-22 |
V
Vente
|
HEALY JAMES
Administrateur non-exécutif
Actionnaire important
|
4 090
-0.6%
6,22
25 457 USD
|
4 090
-0.6%
|
6,22
|
25 457 USD
|
|
|
2011-12-23 |
2011-12-22 |
V
Vente
|
HEALY JAMES
Administrateur non-exécutif
Actionnaire important
|
20 630
-0.6%
6,22
128 405 USD
|
20 630
-0.6%
|
6,22
|
128 405 USD
|
|
|
2011-12-23 |
2011-12-22 |
V
Vente
|
SOFINNOVA VENTURE PARTNERS VI L P
Actionnaire important
|
280
-0.6%
6,22
1 743 USD
|
280
-0.6%
|
6,22
|
1 743 USD
|
|
|
2011-12-23 |
2011-12-22 |
V
Vente
|
SOFINNOVA VENTURE PARTNERS VI L P
Actionnaire important
|
4 090
-0.6%
6,22
25 457 USD
|
4 090
-0.6%
|
6,22
|
25 457 USD
|
|
|
2011-12-23 |
2011-12-22 |
V
Vente
|
SOFINNOVA VENTURE PARTNERS VI L P
Actionnaire important
|
20 630
-0.6%
6,22
128 405 USD
|
20 630
-0.6%
|
6,22
|
128 405 USD
|
|
|
2011-12-23 |
2011-12-21 |
V
Vente
|
HEALY JAMES
Administrateur non-exécutif
Actionnaire important
|
280
-0.6%
6,51
1 823 USD
|
280
-0.6%
|
6,51
|
1 823 USD
|
|
|
2011-12-23 |
2011-12-21 |
V
Vente
|
HEALY JAMES
Administrateur non-exécutif
Actionnaire important
|
4 090
-0.6%
6,51
26 629 USD
|
4 090
-0.6%
|
6,51
|
26 629 USD
|
|
|
2011-12-23 |
2011-12-21 |
V
Vente
|
SOFINNOVA VENTURE PARTNERS VI L P
Actionnaire important
|
280
-0.6%
6,51
1 823 USD
|
280
-0.6%
|
6,51
|
1 823 USD
|
|
|
2011-12-23 |
2011-12-21 |
V
Vente
|
SOFINNOVA VENTURE PARTNERS VI L P
Actionnaire important
|
4 090
-0.6%
6,51
26 629 USD
|
4 090
-0.6%
|
6,51
|
26 629 USD
|
|
|
2011-12-23 |
2011-12-21 |
V
Vente
|
HEALY JAMES
Administrateur non-exécutif
Actionnaire important
|
20 630
-0.6%
6,51
134 318 USD
|
20 630
-0.6%
|
6,51
|
134 318 USD
|
|
|
2011-12-23 |
2011-12-21 |
V
Vente
|
SOFINNOVA VENTURE PARTNERS VI L P
Actionnaire important
|
20 630
-0.6%
6,51
134 318 USD
|
20 630
-0.6%
|
6,51
|
134 318 USD
|
|
|
2011-12-13 |
2011-12-13 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
|
16 200
-0.6%
6,50
105 300 USD
|
16 200
-0.6%
|
6,50
|
105 300 USD
|
|
|
2011-12-13 |
2011-12-09 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
|
40 000
-1.4%
6,75
270 000 USD
|
40 000
-1.4%
|
6,75
|
270 000 USD
|
|
|
2011-11-18 |
2011-11-18 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
Actionnaire important
|
3 000
-0.1%
6,50
19 500 USD
|
3 000
-0.1%
|
6,50
|
19 500 USD
|
|
|
2011-11-18 |
2011-11-17 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
Actionnaire important
|
24 000
-0.8%
6,67
160 080 USD
|
24 000
-0.8%
|
6,67
|
160 080 USD
|
|
|
2011-11-18 |
2011-11-16 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
Actionnaire important
|
25 000
-0.9%
6,87
171 750 USD
|
25 000
-0.9%
|
6,87
|
171 750 USD
|
|
|
2011-11-17 |
2011-11-15 |
VP
Vente planifiée
|
TRUEX PAUL F
President and CEO
Administrateur exécutif
|
15 000
-2.2%
6,96
104 352 USD
|
15 000
-2.2%
|
6,96
|
104 352 USD
|
|
|
2011-11-17 |
2011-11-15 |
VP
Vente planifiée
|
TRUEX PAUL F
President and CEO
Administrateur exécutif
|
15 000
-2.2%
6,96
104 352 USD
|
15 000
-2.2%
|
6,96
|
104 352 USD
|
|
|
2011-11-15 |
2011-11-15 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
Actionnaire important
|
50 000
-1.7%
6,93
346 500 USD
|
50 000
-1.7%
|
6,93
|
346 500 USD
|
|
|
2011-11-15 |
2011-11-14 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
Actionnaire important
|
5 000
-0.2%
6,95
34 750 USD
|
5 000
-0.2%
|
6,95
|
34 750 USD
|
|
|
2011-11-15 |
2011-11-11 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
Actionnaire important
|
5 000
-0.2%
7,14
35 700 USD
|
5 000
-0.2%
|
7,14
|
35 700 USD
|
|
|
2011-11-10 |
2011-11-08 |
V
Vente
|
Hislop Colin
Chief Medical Officer
Dirigeant
|
15 000
-20.6%
6,74
101 163 USD
|
15 000
-20.6%
|
6,74
|
101 163 USD
|
|
|
2011-10-25 |
2011-10-21 |
VP
Vente planifiée
|
TRUEX PAUL F
President and CEO
Administrateur exécutif
|
11 879
-1.8%
6,25
74 244 USD
|
11 879
-1.8%
|
6,25
|
74 244 USD
|
|
|
2011-08-04 |
2011-08-02 |
VP
Vente planifiée
|
LOWE CHRISTOPHER P.
Chief Financial Officer & CBO
Dirigeant
|
300
-6.1%
7,93
2 378 USD
|
300
-6.1%
|
7,93
|
2 378 USD
|
|
|
2011-06-20 |
2011-06-16 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
10
-0.1%
8,67
87 USD
|
10
-0.1%
|
8,67
|
87 USD
|
|
|
2011-06-20 |
2011-06-16 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
281
-0.1%
8,67
2 436 USD
|
281
-0.1%
|
8,67
|
2 436 USD
|
|
|
2011-06-20 |
2011-06-16 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
2 809
-0.1%
8,67
24 354 USD
|
2 809
-0.1%
|
8,67
|
24 354 USD
|
|
|
2011-06-17 |
2011-06-15 |
VP
Vente planifiée
|
TRUEX PAUL F
President and CEO
Administrateur exécutif
|
15 000
-2.2%
8,30
124 539 USD
|
15 000
-2.2%
|
8,30
|
124 539 USD
|
|
|
2011-06-15 |
2011-06-14 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
2
-0.0%
8,81
18 USD
|
2
-0.0%
|
8,81
|
18 USD
|
|
|
2011-06-15 |
2011-06-14 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
63
-0.0%
8,81
555 USD
|
63
-0.0%
|
8,81
|
555 USD
|
|
|
2011-06-15 |
2011-06-14 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
634
-0.0%
8,81
5 586 USD
|
634
-0.0%
|
8,81
|
5 586 USD
|
|
|
2011-06-15 |
2011-06-13 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
4
-0.0%
8,80
35 USD
|
4
-0.0%
|
8,80
|
35 USD
|
|
|
2011-06-15 |
2011-06-13 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
118
-0.0%
8,80
1 038 USD
|
118
-0.0%
|
8,80
|
1 038 USD
|
|
|
2011-06-15 |
2011-06-13 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
1 178
-0.0%
8,80
10 366 USD
|
1 178
-0.0%
|
8,80
|
10 366 USD
|
|
|
2011-06-10 |
2011-06-10 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
Actionnaire important
|
30 000
-1.0%
8,18
245 400 USD
|
30 000
-1.0%
|
8,18
|
245 400 USD
|
|
|
2011-06-10 |
2011-06-09 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
Actionnaire important
|
37 000
-1.2%
8,11
300 070 USD
|
37 000
-1.2%
|
8,11
|
300 070 USD
|
|
|
2011-06-10 |
2011-06-08 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
Actionnaire important
|
33 000
-1.1%
8,02
264 660 USD
|
33 000
-1.1%
|
8,02
|
264 660 USD
|
|
|
2011-05-31 |
2011-05-26 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
16
-0.1%
8,60
138 USD
|
16
-0.1%
|
8,60
|
138 USD
|
|
|
2011-05-31 |
2011-05-26 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
435
-0.1%
8,60
3 741 USD
|
435
-0.1%
|
8,60
|
3 741 USD
|
|
|
2011-05-31 |
2011-05-26 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
4 349
-0.1%
8,60
37 401 USD
|
4 349
-0.1%
|
8,60
|
37 401 USD
|
|
|
2011-05-27 |
2011-05-25 |
V
Vente
|
ORBIMED ADVISORS LLC
Administrateur non-exécutif
Actionnaire important
|
4 800
8,65
41 520 USD
|
4 800
|
8,65
|
41 520 USD
|
|
|
2011-05-25 |
2011-05-25 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
108
-0.6%
8,67
936 USD
|
108
-0.6%
|
8,67
|
936 USD
|
|
|
2011-05-25 |
2011-05-25 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
2 970
-0.6%
8,67
25 750 USD
|
2 970
-0.6%
|
8,67
|
25 750 USD
|
|
|
2011-05-25 |
2011-05-25 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
29 672
-0.6%
8,67
257 256 USD
|
29 672
-0.6%
|
8,67
|
257 256 USD
|
|
|
2011-05-25 |
2011-05-24 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
172
-1.0%
8,42
1 448 USD
|
172
-1.0%
|
8,42
|
1 448 USD
|
|
|
2011-05-25 |
2011-05-24 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
4 734
-1.0%
8,42
39 860 USD
|
4 734
-1.0%
|
8,42
|
39 860 USD
|
|
|
2011-05-25 |
2011-05-24 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
47 290
-1.0%
8,42
398 182 USD
|
47 290
-1.0%
|
8,42
|
398 182 USD
|
|
|
2011-05-25 |
2011-05-23 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
88
-0.5%
8,18
720 USD
|
88
-0.5%
|
8,18
|
720 USD
|
|
|
2011-05-25 |
2011-05-23 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
2 422
-0.5%
8,18
19 812 USD
|
2 422
-0.5%
|
8,18
|
19 812 USD
|
|
|
2011-05-25 |
2011-05-23 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
24 193
-0.5%
8,18
197 899 USD
|
24 193
-0.5%
|
8,18
|
197 899 USD
|
|
|
2011-05-19 |
2011-05-19 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
412
-2.2%
8,03
3 308 USD
|
412
-2.2%
|
8,03
|
3 308 USD
|
|
|
2011-05-19 |
2011-05-19 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
11 337
-2.2%
8,03
91 036 USD
|
11 337
-2.2%
|
8,03
|
91 036 USD
|
|
|
2011-05-19 |
2011-05-19 |
V
Vente
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Actionnaire important
|
113 251
-2.2%
8,03
909 406 USD
|
113 251
-2.2%
|
8,03
|
909 406 USD
|
|
