EMPFIELD JAMES R.

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PS: Planned sale, O: Option / Other

Notification date	Transaction date	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value	Details
2022-08-16	2022-08-12	Xenon Pharmaceuticals Inc (XENE)	S Sale	21,875 -68.6% 38.68 USD 846,125	21,875 -68.6%	38.68	USD 846,125
2022-08-16	2022-08-12	Xenon Pharmaceuticals Inc (XENE)	S Sale	35,868 -52.9% 38.08 USD 1,365,853	35,868 -52.9%	38.08	USD 1,365,853
2022-03-08	2022-03-07	Xenon Pharmaceuticals Inc (XENE)	S Sale	31,048 -75.6% 30.54 USD 948,206	31,048 -75.6%	30.54	USD 948,206
2022-03-08	2022-03-07	Xenon Pharmaceuticals Inc (XENE)	S Sale	1,805 -4.2% 30.62 USD 55,269	1,805 -4.2%	30.62	USD 55,269
2022-03-08	2022-03-04	Xenon Pharmaceuticals Inc (XENE)	S Sale	18,315 -64.7% 30.79 USD 563,919	18,315 -64.7%	30.79	USD 563,919