Chione Ltd

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PS: Planned sale, O: Option / Other

Notification date	Transaction date	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value	Details
2023-06-28	2023-06-26	Acrivon Therapeutics Inc (ACRV)	S Sale	16 -0.0% 12.93 USD 207	16 -0.0%	12.93	USD 207
2023-06-20	2023-06-15	Acrivon Therapeutics Inc (ACRV)	S Sale	2,056 -0.1% 12.14 USD 24,960	2,056 -0.1%	12.14	USD 24,960
2023-06-14	2023-06-14	Acrivon Therapeutics Inc (ACRV)	S Sale	893 -0.0% 12.13 USD 10,832	893 -0.0%	12.13	USD 10,832
2023-06-14	2023-06-13	Acrivon Therapeutics Inc (ACRV)	S Sale	3,000 -0.1% 12.30 USD 36,900	3,000 -0.1%	12.30	USD 36,900
2023-06-14	2023-06-12	Acrivon Therapeutics Inc (ACRV)	S Sale	2,000 -0.1% 12.34 USD 24,680	2,000 -0.1%	12.34	USD 24,680
2022-11-21	2022-11-17	Acrivon Therapeutics Inc (ACRV)	B Purchase	400,000 +11.6% 12.50 USD 5,000,000	400,000 +11.6%	12.50	USD 5,000,000
2019-03-04	2019-02-28	Karyopharm Therapeutics Inc (KPTI)	S Sale	149,624 -2.4% 4.14 USD 619,114	149,624 -2.4%	4.14	USD 619,114
2019-02-27	2019-02-27	Karyopharm Therapeutics Inc (KPTI)	S Sale	558,243 -8.3% 4.51 USD 2,515,834	558,243 -8.3%	4.51	USD 2,515,834
2019-02-27	2019-02-26	Karyopharm Therapeutics Inc (KPTI)	S Sale	123,400 -1.8% 5.00 USD 617,210	123,400 -1.8%	5.00	USD 617,210
2019-02-27	2019-02-25	Karyopharm Therapeutics Inc (KPTI)	S Sale	800,000 -10.5% 4.99 USD 3,994,880	800,000 -10.5%	4.99	USD 3,994,880