JOSEPH TAMARA L

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PS: Planned sale, O: Option / Other

Notification date	Transaction date	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value	Details
2024-02-05	2024-02-02	Spero Therapeutics Inc (SPRO)	S Sale	30,906 -5.5% 1.37 USD 42,341	30,906 -5.5%	1.37	USD 42,341
2023-08-30	2023-08-28	Spero Therapeutics Inc (SPRO)	S Sale	1,854 -0.6% 1.26 USD 2,336	1,854 -0.6%	1.26	USD 2,336
2023-02-03	2023-02-02	Spero Therapeutics Inc (SPRO)	S Sale	3,394 -1.0% 1.86 USD 6,313	3,394 -1.0%	1.86	USD 6,313