MERRIFIELD C ANN

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PS: Planned sale, O: Option / Other

Notification date	Transaction date	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value	Details
2022-06-13	2022-06-10	Lyra Therapeutics Inc (LYRA)	B Purchase	4,000 +54.6% 5.05 USD 20,200	4,000 +54.6%	5.05	USD 20,200
2022-05-17	2022-05-16	Lyra Therapeutics Inc (LYRA)	B Purchase	328 +4.7% 5.00 USD 1,640	328 +4.7%	5.00	USD 1,640
2022-05-17	2022-05-13	Lyra Therapeutics Inc (LYRA)	B Purchase	3,500 +100.0% 4.81 USD 16,846	3,500 +100.0%	4.81	USD 16,846
2021-06-22	2021-06-17	Lyra Therapeutics Inc (LYRA)	B Purchase	3,500 +inf% 8.97 USD 31,395	3,500 +inf%	8.97	USD 31,395
2020-03-12	2020-03-10	InVivo Therapeutics Holdings Corp (NVIV)	B Purchase	3,636 0.00 USD 0	3,636	0.00	USD 0
2019-05-24	2019-05-23	Flexion Therapeutics Inc (FLXN)	B Purchase	8,000 +400.0% 12.64 USD 101,120	8,000 +400.0%	12.64	USD 101,120
2015-08-14	2015-08-12	InVivo Therapeutics Holdings Corp (NVIV)	B Purchase	2,000 +inf% 12.36 USD 24,718	2,000 +inf%	12.36	USD 24,718