Keutzer Timothy

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PS: Planned sale, O: Option / Other

Notification date	Transaction date	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value	Details
2025-02-05	2025-02-05	Spero Therapeutics Inc (SPRO)	S Sale	24,920 -3.3% 0.78 USD 19,438	24,920 -3.3%	0.78	USD 19,438
2025-02-05	2025-02-05	Spero Therapeutics Inc (SPRO)	S Sale	27,643 -3.5% 0.78 USD 21,562	27,643 -3.5%	0.78	USD 21,562
2025-02-05	2025-02-05	Spero Therapeutics Inc (SPRO)	S Sale	3,974 -0.5% 0.78 USD 3,100	3,974 -0.5%	0.78	USD 3,100
2024-08-29	2024-08-27	Spero Therapeutics Inc (SPRO)	S Sale	2,213 -0.4% 1.35 USD 2,988	2,213 -0.4%	1.35	USD 2,988
2024-02-05	2024-02-02	Spero Therapeutics Inc (SPRO)	S Sale	30,971 -5.5% 1.36 USD 42,121	30,971 -5.5%	1.36	USD 42,121
2023-08-30	2023-08-28	Spero Therapeutics Inc (SPRO)	S Sale	1,854 -0.6% 1.26 USD 2,336	1,854 -0.6%	1.26	USD 2,336
2023-02-03	2023-02-02	Spero Therapeutics Inc (SPRO)	S Sale	3,394 -1.0% 1.86 USD 6,313	3,394 -1.0%	1.86	USD 6,313