Ezekowitz Alan

• Purchase • Sale • Planned purchase • Planned sale Net purchase Net sale Earnings

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Abbreviations B: Buy, S: Sell, PP: Planned purchase, PS: Planned sale, O: Option / Other

Notification date	Transaction date	B/S Transaction type	Nb. shares Price Value	Number of shares	Price	Value	Details
2025-03-10	2025-03-07	Septerna Inc (SEPN)	B Purchase	13,319 +12.8% 6.93 USD 92,270	13,319 +12.8%	6.93	USD 92,270
2025-03-06	2025-03-06	Septerna Inc (SEPN)	B Purchase	41,355 +65.9% 6.00 USD 248,130	41,355 +65.9%	6.00	USD 248,130
2025-03-06	2025-03-05	Septerna Inc (SEPN)	B Purchase	37,835 +151.9% 5.82 USD 220,260	37,835 +151.9%	5.82	USD 220,260
2025-03-06	2025-03-04	Septerna Inc (SEPN)	B Purchase	7,491 +43.0% 6.35 USD 47,544	7,491 +43.0%	6.35	USD 47,544