|
2008-10-20 |
2008-10-16 |
S
Sale
|
GOLDMAN SACHS GROUP INC
Large shareholder
|
190,000
-10.4%
0.00
USD 570
|
190,000
-10.4%
|
0.00
|
USD 570
|
|
|
2008-10-20 |
2008-10-15 |
S
Sale
|
GOLDMAN SACHS GROUP INC
Large shareholder
|
65,000
-3.4%
0.00
USD 195
|
65,000
-3.4%
|
0.00
|
USD 195
|
|
|
2008-10-20 |
2008-10-15 |
S
Sale
|
GOLDMAN SACHS GROUP INC
Large shareholder
|
50,000
-2.6%
0.00
USD 160
|
50,000
-2.6%
|
0.00
|
USD 160
|
|
|
2008-10-17 |
2008-10-15 |
S
Sale
|
Baker Bros. Capital (GP), LLC
Large shareholder
|
5,573
-100.0%
0.00
USD 6
|
5,573
-100.0%
|
0.00
|
USD 6
|
|
|
2008-10-17 |
2008-10-15 |
S
Sale
|
14159 capital (GP), LLC
Large shareholder
|
112,451
-100.0%
0.00
USD 112
|
112,451
-100.0%
|
0.00
|
USD 112
|
|
|
2008-10-17 |
2008-10-15 |
S
Sale
|
Baker Brothers Life Sciences Capital (GP), LLC
Large shareholder
|
1,821,429
-100.0%
0.00
USD 1,821
|
1,821,429
-100.0%
|
0.00
|
USD 1,821
|
|
|
2008-04-08 |
2008-04-03 |
S
Sale
|
Baker Bros. Capital (GP), LLC
Large shareholder
|
521
-1.3%
0.11
USD 58
|
521
-1.3%
|
0.11
|
USD 58
|
|
|
2008-04-08 |
2008-04-03 |
S
Sale
|
Baker Brothers Life Sciences Capital (GP), LLC
Large shareholder
|
23,056
-1.2%
0.11
USD 2,557
|
23,056
-1.2%
|
0.11
|
USD 2,557
|
|
|
2008-04-08 |
2008-04-03 |
S
Sale
|
14159 capital (GP), LLC
Large shareholder
|
1,423
-1.2%
0.11
USD 158
|
1,423
-1.2%
|
0.11
|
USD 158
|
|
|
2008-02-28 |
2008-02-26 |
S
Sale
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
600,498
-36.2%
0.70
USD 420,349
|
600,498
-36.2%
|
0.70
|
USD 420,349
|
|
|
2008-02-28 |
2008-02-25 |
S
Sale
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
126,537
-7.1%
0.08
USD 9,629
|
126,537
-7.1%
|
0.08
|
USD 9,629
|
|
|
2008-02-20 |
2008-02-19 |
S
Sale
|
TANG KEVIN C
Large shareholder
|
20,097
-43.6%
0.10
USD 1,917
|
20,097
-43.6%
|
0.10
|
USD 1,917
|
|
|
2008-02-20 |
2008-02-19 |
S
Sale
|
TANG KEVIN C
Large shareholder
|
665,303
-37.3%
0.10
USD 63,470
|
665,303
-37.3%
|
0.10
|
USD 63,470
|
|
|
2008-02-20 |
2008-02-15 |
S
Sale
|
TANG KEVIN C
Large shareholder
|
25,000
-100.0%
0.09
USD 2,148
|
25,000
-100.0%
|
0.09
|
USD 2,148
|
|
|
2008-02-20 |
2008-02-15 |
S
Sale
|
TANG KEVIN C
Large shareholder
|
258,686
-84.9%
0.09
USD 22,221
|
258,686
-84.9%
|
0.09
|
USD 22,221
|
|
|
2008-02-14 |
2008-02-13 |
S
Sale
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
666,216
-27.2%
0.04
USD 28,914
|
666,216
-27.2%
|
0.04
|
USD 28,914
|
|
|
2008-02-14 |
2008-02-12 |
S
Sale
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
817,025
-25.0%
0.06
USD 50,901
|
817,025
-25.0%
|
0.06
|
USD 50,901
|
|
|
2007-06-26 |
2007-06-22 |
B
Purchase
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
709,832
+14.3%
1.50
USD 1,064,748
|
709,832
+14.3%
|
1.50
|
USD 1,064,748
|
|
|
2007-05-24 |
2007-05-22 |
B
Purchase
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
1,000
+0.0%
1.66
USD 1,657
|
1,000
+0.0%
|
1.66
|
USD 1,657
|
|
|
2007-03-23 |
2007-03-21 |
B
Purchase
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
26,350
+0.5%
1.68
USD 44,268
|
26,350
+0.5%
|
1.68
|
USD 44,268
|
|
|
2007-03-20 |
2007-03-16 |
B
Purchase
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
9,700
+0.2%
1.71
USD 16,622
|
9,700
+0.2%
|
1.71
|
USD 16,622
|
|
|
2007-03-16 |
2007-03-15 |
B
Purchase
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
4,800
+0.1%
1.74
USD 8,347
|
4,800
+0.1%
|
1.74
|
USD 8,347
|
|
|
2007-03-16 |
2007-03-14 |
B
Purchase
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
9,500
+0.2%
1.76
USD 16,709
|
9,500
+0.2%
|
1.76
|
USD 16,709
|
|
|
2007-03-16 |
2007-03-13 |
B
Purchase
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
4,300
+0.1%
1.73
USD 7,426
|
4,300
+0.1%
|
1.73
|
USD 7,426
|
|
|
2007-03-09 |
2007-03-08 |
B
Purchase
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
9,458
+0.2%
1.68
USD 15,858
|
9,458
+0.2%
|
1.68
|
USD 15,858
|
|
|
2007-03-09 |
2007-03-07 |
B
Purchase
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
1,000
+0.0%
1.66
USD 1,660
|
1,000
+0.0%
|
1.66
|
USD 1,660
|
|
|
2007-03-07 |
2007-03-06 |
B
Purchase
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
2,500
+0.1%
1.66
USD 4,151
|
2,500
+0.1%
|
1.66
|
USD 4,151
|
|
|
2007-03-07 |
2007-03-05 |
B
Purchase
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
29,362
+0.6%
1.61
USD 47,326
|
29,362
+0.6%
|
1.61
|
USD 47,326
|
|
|
2007-03-05 |
2007-03-02 |
B
Purchase
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
9,223
+0.2%
1.61
USD 14,804
|
9,223
+0.2%
|
1.61
|
USD 14,804
|
|
|
2007-01-19 |
2007-01-17 |
B
Purchase
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
29,000
+0.6%
1.50
USD 43,500
|
29,000
+0.6%
|
1.50
|
USD 43,500
|
|
|
2006-10-25 |
2006-10-23 |
B
Purchase
|
TANG CAPITAL PARTNERS LP
Large shareholder
|
54,736
+21.9%
1.52
USD 83,232
|
54,736
+21.9%
|
1.52
|
USD 83,232
|
|
|
2006-10-25 |
2006-10-23 |
B
Purchase
|
TANG CAPITAL PARTNERS LP
Large shareholder
|
56,950
+3.3%
1.52
USD 86,598
|
56,950
+3.3%
|
1.52
|
USD 86,598
|
|
|
2005-03-07 |
2005-03-03 |
B
Purchase
|
LINK GORDON H JR
CFO and Sr VP, Finance
Officer
|
1,300
+2.2%
0.75
USD 975
|
1,300
+2.2%
|
0.75
|
USD 975
|
|
|
2005-03-01 |
2005-03-01 |
B
Purchase
|
POLLACK ROBERT E
Non-Executive Director
|
1,100
+inf%
0.85
USD 935
|
1,100
+inf%
|
0.85
|
USD 935
|
|
|
2004-08-20 |
2004-08-20 |
B
Purchase
|
LINK GORDON H JR
CFO and Sr VP, Finance
Officer
|
5,000
+9.1%
0.80
USD 4,000
|
5,000
+9.1%
|
0.80
|
USD 4,000
|
|
|
2004-04-15 |
2004-04-13 |
B
Purchase
|
SHAYKIN LEONARD P
CEO
Executive Director
|
100
+0.0%
2.43
USD 243
|
100
+0.0%
|
2.43
|
USD 243
|
|
|
2004-04-15 |
2004-04-13 |
B
Purchase
|
SHAYKIN LEONARD P
CEO
Executive Director
|
547
+0.1%
2.44
USD 1,335
|
547
+0.1%
|
2.44
|
USD 1,335
|
|
|
2004-04-15 |
2004-04-13 |
B
Purchase
|
SHAYKIN LEONARD P
CEO
Executive Director
|
400
+0.1%
2.40
USD 960
|
400
+0.1%
|
2.40
|
USD 960
|
|
|
2004-04-14 |
2004-04-12 |
B
Purchase
|
SHAYKIN LEONARD P
CEO
Executive Director
|
5,000
+0.8%
2.48
USD 12,400
|
5,000
+0.8%
|
2.48
|
USD 12,400
|
|
|
2004-04-14 |
2004-04-12 |
B
Purchase
|
SHAYKIN LEONARD P
CEO
Executive Director
|
4,900
+0.8%
2.49
USD 12,201
|
4,900
+0.8%
|
2.49
|
USD 12,201
|
|
|
2004-04-09 |
2004-04-07 |
B
Purchase
|
PERLE RICHARD N
Non-Executive Director
|
3,000
+30.0%
2.65
USD 7,950
|
3,000
+30.0%
|
2.65
|
USD 7,950
|
|
|
2004-04-01 |
2004-03-31 |
S
Sale
|
PILIA PATRICIA PH D
Executive VP
Executive Director
|
43,700
-5.6%
2.75
USD 120,175
|
43,700
-5.6%
|
2.75
|
USD 120,175
|
|
|
2004-04-01 |
2004-03-31 |
S
Sale
|
PILIA PATRICIA PH D
Executive VP
Executive Director
|
1,600
-0.2%
2.80
USD 4,480
|
1,600
-0.2%
|
2.80
|
USD 4,480
|
|
|
2004-04-01 |
2004-03-30 |
S
Sale
|
PILIA PATRICIA PH D
Executive VP
Executive Director
|
4,000
-0.5%
2.79
USD 11,160
|
4,000
-0.5%
|
2.79
|
USD 11,160
|
|
|
2004-04-01 |
2004-03-30 |
S
Sale
|
PILIA PATRICIA PH D
Executive VP
Executive Director
|
700
-0.1%
2.80
USD 1,960
|
700
-0.1%
|
2.80
|
USD 1,960
|
|
|
2004-03-12 |
2004-03-10 |
B
Purchase
|
SHAYKIN LEONARD P
CEO
Executive Director
|
4,300
+0.7%
2.49
USD 10,707
|
4,300
+0.7%
|
2.49
|
USD 10,707
|
|
|
2004-02-23 |
2004-02-18 |
B
Purchase
|
SHAYKIN LEONARD P
CEO
Executive Director
|
100
+0.0%
2.49
USD 249
|
100
+0.0%
|
2.49
|
USD 249
|
|
|
2004-02-18 |
2004-02-18 |
PS
Planned sale
|
PILIA PATRICIA PH D
Executive VP
Executive Director
|
1,900
-0.2%
2.50
USD 4,750
|
1,900
-0.2%
|
2.50
|
USD 4,750
|
|
|
2004-02-18 |
2004-02-17 |
PS
Planned sale
|
PILIA PATRICIA PH D
Executive VP
Executive Director
|
15,100
-1.9%
2.52
USD 38,052
|
15,100
-1.9%
|
2.52
|
USD 38,052
|
|
|
2004-02-18 |
2004-02-17 |
B
Purchase
|
SHAYKIN LEONARD P
CEO
Executive Director
|
4,653
+0.8%
2.47
USD 11,493
|
4,653
+0.8%
|
2.47
|
USD 11,493
|
|
|
2004-02-18 |
2004-02-17 |
B
Purchase
|
SHAYKIN LEONARD P
CEO
Executive Director
|
5,000
+0.8%
2.49
USD 12,450
|
5,000
+0.8%
|
2.49
|
USD 12,450
|
|
|
2004-02-17 |
2004-02-13 |
PS
Planned sale
|
PILIA PATRICIA PH D
Executive VP
Executive Director
|
30,800
-3.7%
2.50
USD 77,000
|
30,800
-3.7%
|
2.50
|
USD 77,000
|
|
|
2004-02-17 |
2004-02-13 |
PP
Planned purchase
|
SHAYKIN LEONARD P
CEO
Executive Director
|
5,000
+0.8%
2.49
USD 12,450
|
5,000
+0.8%
|
2.49
|
USD 12,450
|
|
|
2004-02-17 |
2004-02-12 |
PS
Planned sale
|
PILIA PATRICIA PH D
Executive VP
Executive Director
|
2,200
-0.3%
2.50
USD 5,500
|
2,200
-0.3%
|
2.50
|
USD 5,500
|
|
|
2004-02-12 |
2004-02-12 |
PP
Planned purchase
|
SHAYKIN LEONARD P
CEO
Executive Director
|
9,000
+1.5%
2.49
USD 22,410
|
9,000
+1.5%
|
2.49
|
USD 22,410
|
|
|
2004-02-12 |
2004-02-12 |
PP
Planned purchase
|
SHAYKIN LEONARD P
CEO
Executive Director
|
1,000
+0.2%
2.46
USD 2,460
|
1,000
+0.2%
|
2.46
|
USD 2,460
|
|
|
2004-02-11 |
2004-02-09 |
PS
Planned sale
|
PILIA PATRICIA PH D
Executive VP
Executive Director
|
25,000
-12.8%
2.60
USD 65,000
|
25,000
-12.8%
|
2.60
|
USD 65,000
|
|
|
2004-02-06 |
2004-02-06 |
B
Purchase
|
LINK GORDON H JR
CFO and Sr VP, Finance
|
4,000
+7.9%
2.40
USD 9,600
|
4,000
+7.9%
|
2.40
|
USD 9,600
|
|
|
2004-02-06 |
2004-02-05 |
B
Purchase
|
LINK GORDON H JR
CFO and Sr VP, Finance
|
900
+1.8%
2.46
USD 2,214
|
900
+1.8%
|
2.46
|
USD 2,214
|
|
|
2004-02-06 |
2004-02-04 |
B
Purchase
|
LINK GORDON H JR
CFO and Sr VP, Finance
|
2,500
+5.3%
2.58
USD 6,450
|
2,500
+5.3%
|
2.58
|
USD 6,450
|
|
