|
2016-08-18 |
2016-08-17 |
B
Purchase
|
DONDERO JAMES D
Large shareholder
|
500
+0.4%
31.92
USD 15,961
|
500
+0.4%
|
31.92
|
USD 15,961
|
|
|
2016-08-18 |
2016-08-16 |
S
Sale
|
Montgomery Monte
Chief Accounting Officer
Officer
|
510
-3.9%
31.92
USD 16,279
|
510
-3.9%
|
31.92
|
USD 16,279
|
|
|
2016-08-15 |
2016-08-11 |
S
Sale
|
DONDERO JAMES D
Large shareholder
|
37,000
-22.4%
31.96
USD 1,182,520
|
37,000
-22.4%
|
31.96
|
USD 1,182,520
|
|
|
2016-07-26 |
2016-07-25 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
343,600
-9.3%
31.98
USD 10,988,328
|
343,600
-9.3%
|
31.98
|
USD 10,988,328
|
|
|
2016-07-26 |
2016-07-22 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
3,700,000
-50.0%
32.00
USD 118,400,000
|
3,700,000
-50.0%
|
32.00
|
USD 118,400,000
|
|
|
2016-06-08 |
2016-06-07 |
S
Sale
|
SPIEGELMAN DANIEL K
Non-Executive Director
|
1,013
-45.0%
19.31
USD 19,562
|
1,013
-45.0%
|
19.31
|
USD 19,562
|
|
|
2016-06-08 |
2016-06-07 |
S
Sale
|
Hillan Kenneth J.
Non-Executive Director
|
1,013
-45.0%
19.31
USD 19,563
|
1,013
-45.0%
|
19.31
|
USD 19,563
|
|
|
2016-06-08 |
2016-06-07 |
S
Sale
|
Butler John P.
Non-Executive Director
|
1,013
-26.2%
19.32
USD 19,570
|
1,013
-26.2%
|
19.32
|
USD 19,570
|
|
|
2016-06-08 |
2016-06-07 |
S
Sale
|
Torley Helen
Non-Executive Director
|
1,013
-45.0%
19.32
USD 19,570
|
1,013
-45.0%
|
19.32
|
USD 19,570
|
|
|
2016-06-08 |
2016-06-07 |
S
Sale
|
HASTINGS PAUL J
Non-Executive Director
|
1,013
-28.9%
19.32
USD 19,573
|
1,013
-28.9%
|
19.32
|
USD 19,573
|
|
|
2016-06-08 |
2016-06-07 |
S
Sale
|
MCGIRR DAVID W J
Non-Executive Director
|
1,013
-27.1%
19.34
USD 19,588
|
1,013
-27.1%
|
19.34
|
USD 19,588
|
|
|
2016-03-16 |
2016-03-16 |
B
Purchase
|
BALL KRISTINE M
Chief Financial Officer & SVP
Officer
|
7,000
+32.9%
12.15
USD 85,050
|
7,000
+32.9%
|
12.15
|
USD 85,050
|
|
|
2016-03-16 |
2016-03-15 |
B
Purchase
|
Schuetz Thomas J.
Non-Executive Director
|
30,000
+757.2%
13.39
USD 401,832
|
30,000
+757.2%
|
13.39
|
USD 401,832
|
|
|
2016-01-04 |
2015-12-31 |
PS
Planned sale
|
Stahl Wilhelm
SVP, Chief Technology Officer
Officer
|
20,000
-57.4%
28.53
USD 570,558
|
20,000
-57.4%
|
28.53
|
USD 570,558
|
|
|
2015-12-23 |
2015-12-23 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
52,058
-0.7%
27.54
USD 1,433,677
|
52,058
-0.7%
|
27.54
|
USD 1,433,677
|
|
|
2015-12-23 |
2015-12-23 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
47,942
-0.6%
26.78
USD 1,283,887
|
47,942
-0.6%
|
26.78
|
USD 1,283,887
|
|
|
2015-12-23 |
2015-12-22 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
38,630
-0.5%
27.02
USD 1,043,783
|
38,630
-0.5%
|
27.02
|
USD 1,043,783
|
|
|
2015-12-23 |
2015-12-22 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
111,370
-1.5%
26.39
USD 2,939,054
|
111,370
-1.5%
|
26.39
|
USD 2,939,054
|
|
|
2015-12-23 |
2015-12-21 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
14,171
-0.2%
28.39
USD 402,315
|
14,171
-0.2%
|
28.39
|
USD 402,315
|
|
|
2015-12-23 |
2015-12-21 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
235,829
-3.0%
27.50
USD 6,485,298
|
235,829
-3.0%
|
27.50
|
USD 6,485,298
|
|
|
2015-12-09 |
2015-12-09 |
PS
Planned sale
|
Berman Lance
Chief Medical Officer and SVP
Officer
|
750
-3.4%
29.50
USD 22,125
|
750
-3.4%
|
29.50
|
USD 22,125
|
|
|
2015-12-09 |
2015-12-07 |
PS
Planned sale
|
Berman Lance
Chief Medical Officer and SVP
Officer
|
30,000
-58.5%
29.78
USD 893,400
|
30,000
-58.5%
|
29.78
|
USD 893,400
|
|
|
2015-12-09 |
2015-12-07 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
800
-1.4%
29.67
USD 23,733
|
800
-1.4%
|
29.67
|
USD 23,733
|
|
|
2015-12-09 |
2015-12-07 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
7,379
-11.8%
28.52
USD 210,451
|
7,379
-11.8%
|
28.52
|
USD 210,451
|
|
|
2015-12-09 |
2015-12-07 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
6,821
-9.8%
27.85
USD 189,949
|
6,821
-9.8%
|
27.85
|
USD 189,949
|
|
|
2015-12-04 |
2015-12-04 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
20,000
-25.2%
25.00
USD 500,000
|
20,000
-25.2%
|
25.00
|
USD 500,000
|
|
|
2015-12-04 |
2015-12-02 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
20,000
-25.2%
25.00
USD 500,000
|
20,000
-25.2%
|
25.00
|
USD 500,000
|
|
|
2015-10-22 |
2015-10-22 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
310,700
+4.1%
12.92
USD 4,014,244
|
310,700
+4.1%
|
12.92
|
USD 4,014,244
|
|
|
2015-10-22 |
2015-10-22 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
189,300
+2.6%
11.97
USD 2,265,921
|
189,300
+2.6%
|
11.97
|
USD 2,265,921
|
|
|
2015-08-19 |
2015-08-17 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
2,366
-5.3%
25.00
USD 59,150
|
2,366
-5.3%
|
25.00
|
USD 59,150
|
|
|
2015-08-03 |
2015-07-31 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
200
-0.8%
34.14
USD 6,828
|
200
-0.8%
|
34.14
|
USD 6,828
|
|
|
2015-08-03 |
2015-07-31 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
9,800
-28.0%
33.51
USD 328,397
|
9,800
-28.0%
|
33.51
|
USD 328,397
|
|
|
2015-08-03 |
2015-07-30 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
200
-0.7%
34.11
USD 6,822
|
200
-0.7%
|
34.11
|
USD 6,822
|
|
|
2015-08-03 |
2015-07-30 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
19,800
-39.6%
33.57
USD 664,751
|
19,800
-39.6%
|
33.57
|
USD 664,751
|
|
|
2015-06-02 |
2015-06-01 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
5,204
-14.8%
36.94
USD 192,255
|
5,204
-14.8%
|
36.94
|
USD 192,255
|
|
|
2015-06-02 |
2015-06-01 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
8,351
-19.2%
35.79
USD 298,893
|
8,351
-19.2%
|
35.79
|
USD 298,893
|
|
|
2015-06-02 |
2015-05-29 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
5,306
-13.2%
36.98
USD 196,208
|
5,306
-13.2%
|
36.98
|
USD 196,208
|
|
|
2015-06-02 |
2015-05-29 |
PS
Planned sale
|
Orwin John A
President & CEO
Executive Director
|
14,694
-26.7%
36.40
USD 534,793
|
14,694
-26.7%
|
36.40
|
USD 534,793
|
|
|
2015-05-20 |
2015-05-18 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
1,457,551
-16.5%
34.13
USD 49,746,216
|
1,457,551
-16.5%
|
34.13
|
USD 49,746,216
|
|
|
2015-05-13 |
2015-05-11 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
5,834
-68.3%
36.06
USD 210,387
|
5,834
-68.3%
|
36.06
|
USD 210,387
|
|
|
2015-04-13 |
2015-04-10 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
5,832
-68.3%
35.35
USD 206,179
|
5,832
-68.3%
|
35.35
|
USD 206,179
|
|
|
2015-03-12 |
2015-03-10 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
5,834
-68.3%
38.67
USD 225,594
|
5,834
-68.3%
|
38.67
|
USD 225,594
|
|
|
2015-03-05 |
2015-03-05 |
PS
Planned sale
|
BALL KRISTINE M
Chief Financial Officer & SVP
Officer
|
3,000
-28.6%
41.00
USD 123,000
|
3,000
-28.6%
|
41.00
|
USD 123,000
|
|
|
2015-03-06 |
2015-03-04 |
PS
Planned sale
|
Lockey Claire
See Remarks
Officer
|
10,000
-64.5%
40.00
USD 400,000
|
10,000
-64.5%
|
40.00
|
USD 400,000
|
|
|
2015-02-27 |
2015-02-27 |
PS
Planned sale
|
Krasnow Ronald A.
See Remarks
Officer
|
348
-6.0%
39.00
USD 13,572
|
348
-6.0%
|
39.00
|
USD 13,572
|
|
|
2015-02-27 |
2015-02-26 |
PS
Planned sale
|
Krasnow Ronald A.
See Remarks
Officer
|
5,000
-46.1%
39.00
USD 195,000
|
5,000
-46.1%
|
39.00
|
USD 195,000
|
|
|
2015-02-25 |
2015-02-24 |
PS
Planned sale
|
Berman Lance
Chief Medical Officer and SVP
Officer
|
2,300
-23.5%
38.63
USD 88,843
|
2,300
-23.5%
|
38.63
|
USD 88,843
|
|
|
2015-02-25 |
2015-02-24 |
PS
Planned sale
|
Berman Lance
Chief Medical Officer and SVP
Officer
|
2,700
-21.6%
37.82
USD 102,106
|
2,700
-21.6%
|
37.82
|
USD 102,106
|
|
|
2015-02-25 |
2015-02-24 |
PS
Planned sale
|
Krasnow Ronald A.
See Remarks
Officer
|
5,000
-24.0%
39.00
USD 195,000
|
5,000
-24.0%
|
39.00
|
USD 195,000
|
|
|
2015-02-10 |
2015-02-10 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
100
-3.6%
32.74
USD 3,274
|
100
-3.6%
|
32.74
|
USD 3,274
|
|
|
2015-02-10 |
2015-02-10 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
5,734
-67.1%
32.10
USD 184,085
|
5,734
-67.1%
|
32.10
|
USD 184,085
|
|
|
2015-01-23 |
2015-01-21 |
PS
Planned sale
|
Lockey Claire
See Remarks
Officer
|
5,000
-47.6%
35.00
USD 175,000
|
5,000
-47.6%
|
35.00
|
USD 175,000
|
|
|
2015-01-23 |
2015-01-21 |
PS
Planned sale
|
BALL KRISTINE M
Chief Financial Officer & SVP
Officer
|
3,000
-28.6%
36.00
USD 108,000
|
3,000
-28.6%
|
36.00
|
USD 108,000
|
|
|
2015-01-23 |
2015-01-21 |
PS
Planned sale
|
Krasnow Ronald A.
See Remarks
Officer
|
55,000
-68.0%
35.00
USD 1,925,000
|
55,000
-68.0%
|
35.00
|
USD 1,925,000
|
|
|
2015-01-16 |
2015-01-14 |
PS
Planned sale
|
Krasnow Ronald A.
See Remarks
Officer
|
1,080
-4.0%
34.09
USD 36,821
|
1,080
-4.0%
|
34.09
|
USD 36,821
|
|
|
2015-01-16 |
2015-01-14 |
PS
Planned sale
|
Krasnow Ronald A.
See Remarks
Officer
|
3,920
-12.7%
33.44
USD 131,073
|
3,920
-12.7%
|
33.44
|
USD 131,073
|
|
|
2015-01-14 |
2015-01-12 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
1,448
-34.8%
32.79
USD 47,483
|
1,448
-34.8%
|
32.79
|
USD 47,483
|
|
|
2015-01-14 |
2015-01-12 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
4,386
-51.3%
32.17
USD 141,106
|
4,386
-51.3%
|
32.17
|
USD 141,106
|
|
|
2014-12-12 |
2014-12-12 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
9,852
-78.4%
32.50
USD 320,190
|
9,852
-78.4%
|
32.50
|
USD 320,190
|
|
|
2014-12-12 |
2014-12-11 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
150
-5.2%
32.50
USD 4,875
|
150
-5.2%
|
32.50
|
USD 4,875
|
|
|
2014-12-12 |
2014-12-10 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
263
-8.8%
32.20
USD 8,468
|
263
-8.8%
|
32.20
|
USD 8,468
|
|
|
2014-12-12 |
2014-12-10 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
3,104
-51.1%
31.52
USD 97,841
|
3,104
-51.1%
|
31.52
|
USD 97,841
|
|
|
2014-12-12 |
2014-12-10 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
800
-11.6%
30.38
USD 24,307
|
800
-11.6%
|
30.38
|
USD 24,307
|
|
|
2014-12-11 |
2014-12-09 |
S
Sale
|
5AM Partners III, LLC
Large shareholder
|
14,814
-23.8%
30.04
USD 445,013
|
14,814
-23.8%
|
30.04
|
USD 445,013
|
|
|
2014-12-11 |
2014-12-09 |
S
Sale
|
5AM Partners III, LLC
Large shareholder
|
574,823
-23.8%
30.04
USD 17,267,683
|
574,823
-23.8%
|
30.04
|
USD 17,267,683
|
|
|
2014-12-10 |
2014-12-09 |
PS
Planned sale
|
Lockey Claire
See Remarks
Officer
|
8,000
-59.3%
30.00
USD 240,000
|
8,000
-59.3%
|
30.00
|
USD 240,000
|
|
|
2014-12-02 |
2014-11-28 |
PS
Planned sale
|
Berman Lance
Chief Medical Officer and SVP
Officer
|
5,000
-40.0%
25.00
USD 125,000
|
5,000
-40.0%
|
25.00
|
USD 125,000
|
|
|
2014-11-26 |
2014-11-25 |
PS
Planned sale
|
Berman Lance
Chief Medical Officer and SVP
Officer
|
15,000
-66.7%
25.00
USD 375,000
|
15,000
-66.7%
|
25.00
|
USD 375,000
|
|
|
2014-11-26 |
2014-11-24 |
PS
Planned sale
|
Berman Lance
Chief Medical Officer and SVP
Officer
|
15,000
-66.7%
25.00
USD 375,000
|
15,000
-66.7%
|
25.00
|
USD 375,000
|
|
|
2014-11-24 |
2014-11-20 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
3,334
-55.1%
22.50
USD 75,015
|
3,334
-55.1%
|
22.50
|
USD 75,015
|
|
|
2014-11-12 |
2014-11-10 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
2,500
-48.0%
20.06
USD 50,144
|
2,500
-48.0%
|
20.06
|
USD 50,144
|
|
|
2014-10-15 |
2014-10-10 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
100
-3.6%
19.86
USD 1,986
|
100
-3.6%
|
19.86
|
USD 1,986
|
|
|
2014-10-15 |
2014-10-10 |
PS
Planned sale
|
VEITINGER KLAUS R DR
Non-Executive Director
|
2,400
-46.0%
19.32
USD 46,357
|
2,400
-46.0%
|
19.32
|
USD 46,357
|
|
|
2014-09-25 |
2014-09-24 |
PS
Planned sale
|
Berman Lance
Chief Medical Officer and SVP
Officer
|
5,000
-40.0%
22.00
USD 110,000
|
5,000
-40.0%
|
22.00
|
USD 110,000
|
|
|
2014-09-18 |
2014-09-17 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
49,000
-0.6%
25.07
USD 1,228,430
|
49,000
-0.6%
|
25.07
|
USD 1,228,430
|
|
