|
2009-09-16 |
2009-09-03 |
S
Sale
|
FREIMAN PAUL E
Non-Executive Director
|
3,466
-10.6%
2.35
USD 8,145
|
3,466
-10.6%
|
2.35
|
USD 8,145
|
|
|
2009-03-13 |
2009-03-11 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
4,100
+0.1%
1.30
USD 5,330
|
4,100
+0.1%
|
1.30
|
USD 5,330
|
|
|
2009-03-13 |
2009-03-11 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
21,000
+0.3%
1.36
USD 28,560
|
21,000
+0.3%
|
1.36
|
USD 28,560
|
|
|
2009-03-10 |
2009-03-10 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
35,000
+0.6%
1.43
USD 50,050
|
35,000
+0.6%
|
1.43
|
USD 50,050
|
|
|
2009-03-10 |
2009-03-09 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
296,362
+4.9%
1.39
USD 411,884
|
296,362
+4.9%
|
1.39
|
USD 411,884
|
|
|
2009-03-10 |
2009-03-06 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
207,800
+3.6%
1.39
USD 288,904
|
207,800
+3.6%
|
1.39
|
USD 288,904
|
|
|
2009-03-10 |
2009-03-06 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
101,500
+1.8%
1.46
USD 148,403
|
101,500
+1.8%
|
1.46
|
USD 148,403
|
|
|
2009-03-09 |
2009-03-05 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
85,000
+1.5%
1.49
USD 126,761
|
85,000
+1.5%
|
1.49
|
USD 126,761
|
|
|
2009-02-27 |
2009-02-25 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
69,200
+1.2%
1.50
USD 103,572
|
69,200
+1.2%
|
1.50
|
USD 103,572
|
|
|
2009-02-26 |
2009-02-24 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
1,300
+0.0%
1.51
USD 1,967
|
1,300
+0.0%
|
1.51
|
USD 1,967
|
|
|
2009-02-25 |
2009-02-23 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
24,140
+0.4%
1.42
USD 34,238
|
24,140
+0.4%
|
1.42
|
USD 34,238
|
|
|
2009-02-23 |
2009-02-19 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
45,000
+0.8%
1.47
USD 66,258
|
45,000
+0.8%
|
1.47
|
USD 66,258
|
|
|
2009-02-19 |
2009-02-17 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
665,000
+13.7%
1.65
USD 1,096,652
|
665,000
+13.7%
|
1.65
|
USD 1,096,652
|
|
|
2009-01-28 |
2009-01-16 |
B
Purchase
|
PERCEPTIVE ADVISORS LLC
Large shareholder
|
23,900
+0.4%
5.00
USD 119,500
|
23,900
+0.4%
|
5.00
|
USD 119,500
|
|
|
2009-01-12 |
2009-01-09 |
B
Purchase
|
TANG KEVIN C
Large shareholder
|
1,015,000
+26.5%
1.99
USD 2,023,403
|
1,015,000
+26.5%
|
1.99
|
USD 2,023,403
|
|
|
2009-01-12 |
2009-01-06 |
B
Purchase
|
PERCEPTIVE ADVISORS LLC
Large shareholder
|
25,000
+0.4%
5.00
USD 125,000
|
25,000
+0.4%
|
5.00
|
USD 125,000
|
|
|
2009-01-12 |
2008-12-29 |
B
Purchase
|
PERCEPTIVE ADVISORS LLC
Large shareholder
|
2,300
+0.0%
5.00
USD 11,500
|
2,300
+0.0%
|
5.00
|
USD 11,500
|
|
|
2009-01-06 |
2008-12-29 |
B
Purchase
|
PERCEPTIVE ADVISORS LLC
Large shareholder
|
4,700
+0.1%
5.00
USD 23,500
|
4,700
+0.1%
|
5.00
|
USD 23,500
|
|
|
2008-11-10 |
2008-11-06 |
S
Sale
|
VANLENT ANNE
Non-Executive Director
|
6,900
-13.4%
1.01
USD 6,969
|
6,900
-13.4%
|
1.01
|
USD 6,969
|
|
|
2008-11-06 |
2008-10-24 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
3,000
+0.0%
5.00
USD 15,000
|
3,000
+0.0%
|
5.00
|
USD 15,000
|
|
|
2008-10-23 |
2008-10-15 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
300
+0.0%
5.00
USD 1,500
|
300
+0.0%
|
5.00
|
USD 1,500
|
|
|
2008-10-23 |
2008-09-29 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
4,500
+0.1%
5.00
USD 22,500
|
4,500
+0.1%
|
5.00
|
USD 22,500
|
|
|
2008-07-17 |
2008-06-23 |
B
Purchase
|
PERCEPTIVE ADVISORS LLC
Large shareholder
|
91,500
+1.5%
5.00
USD 457,500
|
91,500
+1.5%
|
5.00
|
USD 457,500
|
|
|
2008-06-12 |
2008-06-10 |
S
Sale
|
FREIMAN PAUL E
Non-Executive Director
|
1,700
-6.8%
3.08
USD 5,236
|
1,700
-6.8%
|
3.08
|
USD 5,236
|
|
|
2008-06-12 |
2008-06-10 |
S
Sale
|
FREIMAN PAUL E
Non-Executive Director
|
3,300
-11.7%
3.09
USD 10,197
|
3,300
-11.7%
|
3.09
|
USD 10,197
|
|
|
2008-05-20 |
2008-05-15 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
2,500
+0.0%
5.00
USD 12,500
|
2,500
+0.0%
|
5.00
|
USD 12,500
|
|
|
2008-05-23 |
2008-05-12 |
S
Sale
|
FREIMAN PAUL E
Non-Executive Director
|
3,600
-11.3%
2.64
USD 9,504
|
3,600
-11.3%
|
2.64
|
USD 9,504
|
|
|
2008-05-23 |
2008-05-12 |
S
Sale
|
FREIMAN PAUL E
Non-Executive Director
|
400
-1.2%
2.63
USD 1,052
|
400
-1.2%
|
2.63
|
USD 1,052
|
|
|
2008-05-12 |
2008-05-07 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
2,500
+0.0%
5.00
USD 12,500
|
2,500
+0.0%
|
5.00
|
USD 12,500
|
|
|
2008-04-01 |
2008-03-20 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
90,000
+49.8%
5.00
USD 450,000
|
90,000
+49.8%
|
5.00
|
USD 450,000
|
|
|
2008-04-01 |
2008-03-20 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
1,238,500
+24.5%
5.00
USD 6,192,500
|
1,238,500
+24.5%
|
5.00
|
USD 6,192,500
|
|
|
2008-04-01 |
2008-03-20 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
11,800
+0.2%
7.50
USD 88,500
|
11,800
+0.2%
|
7.50
|
USD 88,500
|
|
|
2008-03-20 |
2008-03-18 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
800
+0.0%
7.50
USD 6,000
|
800
+0.0%
|
7.50
|
USD 6,000
|
|
|
2008-03-20 |
2008-03-12 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
7,400
+0.1%
5.00
USD 37,000
|
7,400
+0.1%
|
5.00
|
USD 37,000
|
|
|
2008-03-20 |
2008-03-11 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
1,850,000
+58.1%
3.08
USD 5,698,000
|
1,850,000
+58.1%
|
3.08
|
USD 5,698,000
|
|
|
2008-03-20 |
2008-03-11 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
87,900
+2.8%
5.00
USD 439,500
|
87,900
+2.8%
|
5.00
|
USD 439,500
|
|
|
2008-03-20 |
2008-03-10 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
24,000
+15.3%
7.50
USD 180,000
|
24,000
+15.3%
|
7.50
|
USD 180,000
|
|
|
2008-03-20 |
2008-03-10 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
10,500
+0.3%
5.00
USD 52,500
|
10,500
+0.3%
|
5.00
|
USD 52,500
|
|
|
2008-03-20 |
2008-03-10 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
307,700
+11.1%
7.50
USD 2,307,750
|
307,700
+11.1%
|
7.50
|
USD 2,307,750
|
|
|
2008-03-10 |
2008-03-05 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
52,100
+1.9%
5.00
USD 260,500
|
52,100
+1.9%
|
5.00
|
USD 260,500
|
|
|
2008-03-10 |
2008-03-04 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
13,600
+0.5%
5.00
USD 68,000
|
13,600
+0.5%
|
5.00
|
USD 68,000
|
|
|
2008-02-22 |
2008-02-20 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
600
+0.0%
7.50
USD 4,500
|
600
+0.0%
|
7.50
|
USD 4,500
|
|
|
2008-02-22 |
2008-02-19 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
1,500
+0.1%
7.50
USD 11,250
|
1,500
+0.1%
|
7.50
|
USD 11,250
|
|
|
2008-02-19 |
2008-02-12 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
5,000
+0.2%
4.14
USD 20,694
|
5,000
+0.2%
|
4.14
|
USD 20,694
|
|
|
2008-02-05 |
2008-02-01 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
2,520
+1.6%
5.34
USD 13,452
|
2,520
+1.6%
|
5.34
|
USD 13,452
|
|
|
2008-02-05 |
2008-02-01 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
39,480
+1.5%
5.34
USD 210,748
|
39,480
+1.5%
|
5.34
|
USD 210,748
|
|
|
2008-02-05 |
2008-01-31 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
9,600
+6.6%
4.97
USD 47,748
|
9,600
+6.6%
|
4.97
|
USD 47,748
|
|
|
2008-02-05 |
2008-01-31 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
150,400
+6.0%
4.97
USD 748,044
|
150,400
+6.0%
|
4.97
|
USD 748,044
|
|
|
2008-02-01 |
2008-01-30 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
10,200
+7.6%
4.74
USD 48,396
|
10,200
+7.6%
|
4.74
|
USD 48,396
|
|
|
2008-02-01 |
2008-01-30 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
159,800
+6.8%
4.74
USD 758,203
|
159,800
+6.8%
|
4.74
|
USD 758,203
|
|
|
2008-01-31 |
2008-01-29 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
7,500
+5.9%
4.58
USD 34,374
|
7,500
+5.9%
|
4.58
|
USD 34,374
|
|
|
2008-01-31 |
2008-01-29 |
B
Purchase
|
EDELMAN JOSEPH
Large shareholder
|
117,500
+5.3%
4.58
USD 538,526
|
117,500
+5.3%
|
4.58
|
USD 538,526
|
|
|
2007-09-14 |
2007-09-14 |
B
Purchase
|
Palleiko Benjamin L
SVP, Corporate Dev. & CFO
Officer
|
1,500
+150.0%
10.87
USD 16,305
|
1,500
+150.0%
|
10.87
|
USD 16,305
|
|
|
2006-12-13 |
2006-12-11 |
S
Sale
|
HENNESSEY ROBERT
Non-Executive Director
|
83,333
-71.9%
16.64
USD 1,386,611
|
83,333
-71.9%
|
16.64
|
USD 1,386,611
|
|
|
2006-09-27 |
2006-09-05 |
S
Sale
|
BAICHWAL ANAND
Chief Scientific Officer
Officer
|
3,213
-49.8%
17.55
USD 56,388
|
3,213
-49.8%
|
17.55
|
USD 56,388
|
|
|
2006-06-28 |
2006-06-27 |
S
Sale
|
Joslyn Alan
Sr. Vice President, R&D.
Officer
|
15,000
-98.3%
21.97
USD 329,574
|
15,000
-98.3%
|
21.97
|
USD 329,574
|
|
|
2006-06-28 |
2006-06-26 |
S
Sale
|
Joslyn Alan
Sr. Vice President, R&D.
Officer
|
10,000
-97.5%
21.78
USD 217,751
|
10,000
-97.5%
|
21.78
|
USD 217,751
|
|
|
2006-06-26 |
2006-06-23 |
S
Sale
|
BAICHWAL ANAND
Chief Scientific Officer
Officer
|
15,000
-82.3%
22.06
USD 330,866
|
15,000
-82.3%
|
22.06
|
USD 330,866
|
|
|
2006-05-09 |
2006-05-08 |
S
Sale
|
BAICHWAL ANAND
Chief Scientific Officer
Officer
|
6,863
-100.0%
20.20
USD 138,633
|
6,863
-100.0%
|
20.20
|
USD 138,633
|
|
|
2006-05-09 |
2006-05-05 |
S
Sale
|
BAICHWAL ANAND
Chief Scientific Officer
Officer
|
1,500
-17.9%
20.29
USD 30,435
|
1,500
-17.9%
|
20.29
|
USD 30,435
|
|
|
2006-05-03 |
2006-05-01 |
S
Sale
|
FREIMAN PAUL E
Non-Executive Director
|
10,000
-44.6%
19.90
USD 199,000
|
10,000
-44.6%
|
19.90
|
USD 199,000
|
|
|
2006-02-22 |
2006-02-17 |
S
Sale
|
Joslyn Alan
Sr. Vice President, R&D.
Officer
|
4,000
-100.0%
23.51
USD 94,033
|
4,000
-100.0%
|
23.51
|
USD 94,033
|
|
|
2006-02-16 |
2006-02-16 |
S
Sale
|
Joslyn Alan
Sr. Vice President, R&D.
Officer
|
4,750
-100.0%
23.16
USD 110,002
|
4,750
-100.0%
|
23.16
|
USD 110,002
|
|
|
2006-02-07 |
2006-02-03 |
S
Sale
|
BAICHWAL ANAND
Chief Scientific Officer
Officer
|
15,000
-100.0%
21.80
USD 327,027
|
15,000
-100.0%
|
21.80
|
USD 327,027
|
|
|
2006-01-27 |
2006-01-26 |
S
Sale
|
Joslyn Alan
Sr. Vice President, R&D.
Officer
|
10,000
-100.0%
20.07
USD 200,715
|
10,000
-100.0%
|
20.07
|
USD 200,715
|
|
|
2006-01-06 |
2006-01-05 |
S
Sale
|
Joslyn Alan
Sr. Vice President, R&D.
Officer
|
5,000
-100.0%
20.51
USD 102,550
|
5,000
-100.0%
|
20.51
|
USD 102,550
|
|
|
2006-01-06 |
2006-01-04 |
S
Sale
|
Joslyn Alan
Sr. Vice President, R&D.
Officer
|
2,000
-100.0%
20.01
USD 40,016
|
2,000
-100.0%
|
20.01
|
USD 40,016
|
|
|
2006-01-04 |
2005-12-23 |
S
Sale
|
Joslyn Alan
Sr. Vice President, R&D.
Officer
|
2,000
-100.0%
19.81
USD 39,612
|
2,000
-100.0%
|
19.81
|
USD 39,612
|
|
|
2005-12-23 |
2005-12-22 |
S
Sale
|
Joslyn Alan
Sr. Vice President, R&D.
Officer
|
1,000
-100.0%
19.50
USD 19,500
|
1,000
-100.0%
|
19.50
|
USD 19,500
|
|
|
2005-12-19 |
2005-12-16 |
S
Sale
|
Joslyn Alan
Sr. Vice President, R&D.
Officer
|
1,000
-100.0%
19.07
USD 19,070
|
1,000
-100.0%
|
19.07
|
USD 19,070
|
|
|
2005-12-06 |
2005-12-02 |
S
Sale
|
GOOD JENNIFER L
President & COO
Officer
|
2,000
-25.4%
18.02
USD 36,036
|
2,000
-25.4%
|
18.02
|
USD 36,036
|
|
|
2005-12-06 |
2005-12-02 |
S
Sale
|
GOOD JENNIFER L
President & COO
Officer
|
17,758
-69.3%
18.02
USD 319,964
|
17,758
-69.3%
|
18.02
|
USD 319,964
|
|
|
2005-11-14 |
2005-11-11 |
S
Sale
|
Joslyn Alan
Sr. Vice President, R&D.
Officer
|
2,000
-100.0%
16.14
USD 32,286
|
2,000
-100.0%
|
16.14
|
USD 32,286
|
|
|
2005-10-07 |
2005-10-06 |
S
Sale
|
Joslyn Alan
Sr. Vice President, R&D.
Officer
|
2,000
-100.0%
17.26
USD 34,520
|
2,000
-100.0%
|
17.26
|
USD 34,520
|
|
|
2005-10-05 |
2005-10-03 |
S
Sale
|
GOOD JENNIFER L
Chief Financial Officer
Officer
|
500
-6.0%
18.00
USD 9,000
|
500
-6.0%
|
18.00
|
USD 9,000
|
|
