|
2022-11-29 |
2022-11-28 |
S
Sale
|
CAPPS VICKIE L
Non-Executive Director
|
42,242
-92.6%
0.10
USD 4,342
|
42,242
-92.6%
|
0.10
|
USD 4,342
|
|
|
2022-03-29 |
2022-03-28 |
S
Sale
|
Foster Alan Charles
Chief Scientific Officer
Officer
|
2,559
-1.4%
2.41
USD 6,175
|
2,559
-1.4%
|
2.41
|
USD 6,175
|
|
|
2022-03-29 |
2022-03-28 |
S
Sale
|
Cayer Paul E
Ch. Financial & Business Offcr
Officer
|
5,624
-2.5%
2.41
USD 13,571
|
5,624
-2.5%
|
2.41
|
USD 13,571
|
|
|
2022-03-29 |
2022-03-28 |
S
Sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
3,325
-2.2%
2.41
USD 8,023
|
3,325
-2.2%
|
2.41
|
USD 8,023
|
|
|
2022-03-29 |
2022-03-28 |
S
Sale
|
Weber David Allen
President & CEO
Executive Director
|
11,243
-2.9%
2.41
USD 27,129
|
11,243
-2.9%
|
2.41
|
USD 27,129
|
|
|
2022-03-29 |
2022-03-25 |
S
Sale
|
Foster Alan Charles
Chief Scientific Officer
Officer
|
1,827
-1.0%
2.39
USD 4,363
|
1,827
-1.0%
|
2.39
|
USD 4,363
|
|
|
2022-03-29 |
2022-03-25 |
S
Sale
|
Cayer Paul E
Ch. Financial & Business Offcr
Officer
|
4,015
-1.7%
2.39
USD 9,588
|
4,015
-1.7%
|
2.39
|
USD 9,588
|
|
|
2022-03-29 |
2022-03-25 |
S
Sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
2,374
-1.6%
2.39
USD 5,669
|
2,374
-1.6%
|
2.39
|
USD 5,669
|
|
|
2022-03-29 |
2022-03-25 |
S
Sale
|
Weber David Allen
President & CEO
Executive Director
|
8,026
-2.0%
2.39
USD 19,166
|
8,026
-2.0%
|
2.39
|
USD 19,166
|
|
|
2021-03-03 |
2021-03-03 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
113,935
-100.0%
2.70
USD 307,397
|
113,935
-100.0%
|
2.70
|
USD 307,397
|
|
|
2021-03-03 |
2021-03-03 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
207,245
-100.0%
2.70
USD 559,147
|
207,245
-100.0%
|
2.70
|
USD 559,147
|
|
|
2021-03-02 |
2021-03-02 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
138,199
-54.8%
2.90
USD 400,639
|
138,199
-54.8%
|
2.90
|
USD 400,639
|
|
|
2021-03-02 |
2021-03-02 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
251,375
-54.8%
2.90
USD 728,736
|
251,375
-54.8%
|
2.90
|
USD 728,736
|
|
|
2021-03-02 |
2021-03-01 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
61,619
-19.6%
2.86
USD 175,984
|
61,619
-19.6%
|
2.86
|
USD 175,984
|
|
|
2021-03-02 |
2021-03-01 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
112,081
-19.6%
2.86
USD 320,103
|
112,081
-19.6%
|
2.86
|
USD 320,103
|
|
|
2021-03-02 |
2021-02-26 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
117,262
-27.2%
2.83
USD 331,851
|
117,262
-27.2%
|
2.83
|
USD 331,851
|
|
|
2021-03-02 |
2021-02-26 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
213,292
-27.2%
2.83
USD 603,616
|
213,292
-27.2%
|
2.83
|
USD 603,616
|
|
|
2021-02-25 |
2021-02-25 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
110,361
-20.4%
2.95
USD 326,006
|
110,361
-20.4%
|
2.95
|
USD 326,006
|
|
|
2021-02-25 |
2021-02-25 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
200,739
-20.4%
2.95
USD 592,983
|
200,739
-20.4%
|
2.95
|
USD 592,983
|
|
|
2021-02-25 |
2021-02-24 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
178,484
-24.8%
2.98
USD 532,239
|
178,484
-24.8%
|
2.98
|
USD 532,239
|
|
|
2021-02-25 |
2021-02-24 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
324,651
-24.8%
2.98
USD 968,109
|
324,651
-24.8%
|
2.98
|
USD 968,109
|
|
|
2021-02-25 |
2021-02-23 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
95,113
-11.7%
2.89
USD 274,686
|
95,113
-11.7%
|
2.89
|
USD 274,686
|
|
|
2021-02-25 |
2021-02-23 |
S
Sale
|
Lichter Jay
Non-Executive Director
|
173,005
-11.7%
2.89
USD 499,638
|
173,005
-11.7%
|
2.89
|
USD 499,638
|
|
|
2017-06-27 |
2017-06-26 |
PS
Planned sale
|
LOUMEAU ERIC J
GC & Chief Compliance Officer
|
1,206
-100.0%
18.75
USD 22,613
|
1,206
-100.0%
|
18.75
|
USD 22,613
|
|
|
2017-06-27 |
2017-06-23 |
PS
Planned sale
|
LOUMEAU ERIC J
GC & Chief Compliance Officer
|
2,316
-65.8%
18.50
USD 42,846
|
2,316
-65.8%
|
18.50
|
USD 42,846
|
|
|
2016-11-22 |
2016-11-21 |
PS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
1,456
-13.3%
18.07
USD 26,303
|
1,456
-13.3%
|
18.07
|
USD 26,303
|
|
|
2016-11-22 |
2016-11-18 |
PS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
9,169
-49.2%
18.07
USD 165,703
|
9,169
-49.2%
|
18.07
|
USD 165,703
|
|
|
2016-09-08 |
2016-09-06 |
PS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
5,304
-35.9%
17.95
USD 95,207
|
5,304
-35.9%
|
17.95
|
USD 95,207
|
|
|
2016-09-08 |
2016-09-06 |
PS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
3,813
-20.5%
17.95
USD 68,443
|
3,813
-20.5%
|
17.95
|
USD 68,443
|
|
|
2016-09-08 |
2016-09-06 |
PS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
12,133
-39.5%
17.95
USD 217,787
|
12,133
-39.5%
|
17.95
|
USD 217,787
|
|
|
2015-12-22 |
2015-12-21 |
PS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
8,061
-47.5%
28.38
USD 228,753
|
8,061
-47.5%
|
28.38
|
USD 228,753
|
|
|
2015-12-22 |
2015-12-21 |
PS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
13,189
-43.7%
27.83
USD 367,074
|
13,189
-43.7%
|
27.83
|
USD 367,074
|
|
|
2015-12-18 |
2015-12-17 |
PS
Planned sale
|
Cayer Paul E
Ch. Financial & Business Offcr
Officer
|
300
-3.0%
30.19
USD 9,056
|
300
-3.0%
|
30.19
|
USD 9,056
|
|
|
2015-12-18 |
2015-12-17 |
PS
Planned sale
|
Cayer Paul E
Ch. Financial & Business Offcr
Officer
|
2,700
-21.4%
29.65
USD 80,045
|
2,700
-21.4%
|
29.65
|
USD 80,045
|
|
|
2015-12-16 |
2015-12-15 |
PS
Planned sale
|
Weber David Allen
President & CEO
Executive Director
|
5,208
-22.8%
27.25
USD 141,917
|
5,208
-22.8%
|
27.25
|
USD 141,917
|
|
|
2015-12-16 |
2015-12-14 |
S
Sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
100
-7.4%
27.70
USD 2,770
|
100
-7.4%
|
27.70
|
USD 2,770
|
|
|
2015-12-16 |
2015-12-14 |
S
Sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
1,289
-48.7%
27.26
USD 35,136
|
1,289
-48.7%
|
27.26
|
USD 35,136
|
|
|
2015-12-16 |
2015-12-14 |
S
Sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
1,289
-32.8%
26.15
USD 33,706
|
1,289
-32.8%
|
26.15
|
USD 33,706
|
|
|
2015-12-16 |
2015-12-14 |
PS
Planned sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
2,322
-37.1%
25.14
USD 58,363
|
2,322
-37.1%
|
25.14
|
USD 58,363
|
|
|
2015-11-30 |
2015-11-30 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
590
-0.0%
29.22
USD 17,240
|
590
-0.0%
|
29.22
|
USD 17,240
|
|
|
2015-11-30 |
2015-11-30 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
2,716
-0.1%
28.64
USD 77,786
|
2,716
-0.1%
|
28.64
|
USD 77,786
|
|
|
2015-11-30 |
2015-11-30 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
590
-0.0%
29.22
USD 17,240
|
590
-0.0%
|
29.22
|
USD 17,240
|
|
|
2015-11-30 |
2015-11-30 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
2,716
-0.1%
28.64
USD 77,786
|
2,716
-0.1%
|
28.64
|
USD 77,786
|
|
|
2015-11-30 |
2015-11-27 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
29,000
-1.5%
28.97
USD 840,130
|
29,000
-1.5%
|
28.97
|
USD 840,130
|
|
|
2015-11-30 |
2015-11-27 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
29,000
-1.5%
28.97
USD 840,130
|
29,000
-1.5%
|
28.97
|
USD 840,130
|
|
|
2015-11-30 |
2015-11-25 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
34,800
-1.8%
28.91
USD 1,006,068
|
34,800
-1.8%
|
28.91
|
USD 1,006,068
|
|
|
2015-11-30 |
2015-11-25 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
34,800
-1.8%
28.91
USD 1,006,068
|
34,800
-1.8%
|
28.91
|
USD 1,006,068
|
|
|
2015-11-24 |
2015-11-24 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
36,100
-1.8%
28.75
USD 1,037,875
|
36,100
-1.8%
|
28.75
|
USD 1,037,875
|
|
|
2015-11-24 |
2015-11-24 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
36,100
-1.8%
28.75
USD 1,037,875
|
36,100
-1.8%
|
28.75
|
USD 1,037,875
|
|
|
2015-11-24 |
2015-11-23 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
80,800
-4.0%
28.45
USD 2,298,760
|
80,800
-4.0%
|
28.45
|
USD 2,298,760
|
|
|
2015-11-24 |
2015-11-23 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
80,800
-4.0%
28.45
USD 2,298,760
|
80,800
-4.0%
|
28.45
|
USD 2,298,760
|
|
|
2015-11-24 |
2015-11-20 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
83,900
-4.0%
28.59
USD 2,398,701
|
83,900
-4.0%
|
28.59
|
USD 2,398,701
|
|
|
2015-11-24 |
2015-11-20 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
83,900
-4.0%
28.59
USD 2,398,701
|
83,900
-4.0%
|
28.59
|
USD 2,398,701
|
|
|
2015-11-19 |
2015-11-19 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
127,300
-5.7%
28.60
USD 3,640,780
|
127,300
-5.7%
|
28.60
|
USD 3,640,780
|
|
|
2015-11-19 |
2015-11-19 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
127,300
-5.7%
28.60
USD 3,640,780
|
127,300
-5.7%
|
28.60
|
USD 3,640,780
|
|
|
2015-11-19 |
2015-11-17 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
200
-0.0%
29.09
USD 5,818
|
200
-0.0%
|
29.09
|
USD 5,818
|
|
|
2015-11-19 |
2015-11-17 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
200
-0.0%
29.09
USD 5,818
|
200
-0.0%
|
29.09
|
USD 5,818
|
|
|
2015-11-19 |
2015-11-17 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
10,898
-0.5%
28.80
USD 313,862
|
10,898
-0.5%
|
28.80
|
USD 313,862
|
|
|
2015-11-19 |
2015-11-17 |
S
Sale
|
Khuong Chau Quang
Non-Executive Director
|
10,898
-0.5%
28.80
USD 313,862
|
10,898
-0.5%
|
28.80
|
USD 313,862
|
|
|
2015-11-17 |
2015-11-17 |
PS
Planned sale
|
Cayer Paul E
Ch. Financial & Business Offcr
Officer
|
3,000
-23.8%
28.69
USD 86,057
|
3,000
-23.8%
|
28.69
|
USD 86,057
|
|
|
2015-11-17 |
2015-11-16 |
S
Sale
|
Weber David Allen
President & CEO
Executive Director
|
100
-0.6%
29.25
USD 2,925
|
100
-0.6%
|
29.25
|
USD 2,925
|
|
|
2015-11-17 |
2015-11-16 |
PS
Planned sale
|
Weber David Allen
President & CEO
Executive Director
|
5,108
-22.4%
28.56
USD 145,887
|
5,108
-22.4%
|
28.56
|
USD 145,887
|
|
|
2015-11-13 |
2015-11-13 |
PS
Planned sale
|
Weber David Allen
President & CEO
Executive Director
|
10,416
-95.1%
30.95
USD 322,375
|
10,416
-95.1%
|
30.95
|
USD 322,375
|
|
|
2015-11-12 |
2015-11-11 |
PS
Planned sale
|
Cayer Paul E
CFO/Ch. Business Offcr & Sec.
Officer
|
3,000
-23.8%
24.95
USD 74,850
|
3,000
-23.8%
|
24.95
|
USD 74,850
|
|
|
2015-11-12 |
2015-11-11 |
PS
Planned sale
|
Weber David Allen
President & CEO
Executive Director
|
5,208
-90.6%
24.95
USD 129,940
|
5,208
-90.6%
|
24.95
|
USD 129,940
|
|
|
2015-09-22 |
2015-09-21 |
PS
Planned sale
|
LeBel Carl
Chief Scientific Officer
Officer
|
21,250
-70.4%
24.36
USD 517,576
|
21,250
-70.4%
|
24.36
|
USD 517,576
|
|
|
2015-09-18 |
2015-09-17 |
PS
Planned sale
|
Cayer Paul E
CFO/Ch. Business Offcr & Sec.
Officer
|
3,000
-23.8%
24.95
USD 74,850
|
3,000
-23.8%
|
24.95
|
USD 74,850
|
|
|
2015-09-16 |
2015-09-15 |
PS
Planned sale
|
Weber David Allen
President & CEO
Executive Director
|
5,216
-90.6%
24.95
USD 130,139
|
5,216
-90.6%
|
24.95
|
USD 130,139
|
|
|
2015-09-15 |
2015-09-14 |
PS
Planned sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
5,000
-79.9%
23.98
USD 119,897
|
5,000
-79.9%
|
23.98
|
USD 119,897
|
|
|
2015-06-17 |
2015-06-15 |
PS
Planned sale
|
Savel Robert Michael II
Chief Technical Officer
Officer
|
25,000
-95.2%
23.73
USD 593,285
|
25,000
-95.2%
|
23.73
|
USD 593,285
|
|
|
2015-05-27 |
2015-05-22 |
B
Purchase
|
CAPPS VICKIE L
Non-Executive Director
|
1,600
+inf%
24.35
USD 38,960
|
1,600
+inf%
|
24.35
|
USD 38,960
|
|
|
2015-05-27 |
2015-05-22 |
B
Purchase
|
CAPPS VICKIE L
Non-Executive Director
|
3,400
+inf%
24.36
USD 82,808
|
3,400
+inf%
|
24.36
|
USD 82,808
|
|
|
2014-08-21 |
2014-08-19 |
B
Purchase
|
Novo A/S
SEE REMARKS
Large shareholder
|
15,690
+0.7%
15.50
USD 243,135
|
15,690
+0.7%
|
15.50
|
USD 243,135
|
|
|
2014-08-19 |
2014-08-18 |
B
Purchase
|
Novo A/S
SEE REMARKS
Large shareholder
|
171,875
+8.6%
16.00
USD 2,750,000
|
171,875
+8.6%
|
16.00
|
USD 2,750,000
|
|
|
2014-08-19 |
2014-08-18 |
B
Purchase
|
Avalon Ventures VIII LP
Large shareholder
|
109,375
+15.5%
16.00
USD 1,750,000
|
109,375
+15.5%
|
16.00
|
USD 1,750,000
|
|
