|
2009-12-30 |
2009-12-29 |
S
Sale
|
STUPPIN JOHN B
Non-Executive Director
|
5,608
-3.0%
0.12
USD 673
|
5,608
-3.0%
|
0.12
|
USD 673
|
|
|
2009-10-26 |
2009-10-26 |
B
Purchase
|
Firefly Value Partners, LP
Large shareholder
|
81,561
+3.6%
0.90
USD 73,397
|
81,561
+3.6%
|
0.90
|
USD 73,397
|
|
|
2009-10-26 |
2009-10-26 |
B
Purchase
|
Firefly Value Partners, LP
Large shareholder
|
99,365
+3.6%
0.90
USD 89,419
|
99,365
+3.6%
|
0.90
|
USD 89,419
|
|
|
2009-10-26 |
2009-10-22 |
B
Purchase
|
Firefly Value Partners, LP
Large shareholder
|
135,442
+6.4%
0.91
USD 123,022
|
135,442
+6.4%
|
0.91
|
USD 123,022
|
|
|
2009-10-26 |
2009-10-22 |
B
Purchase
|
Firefly Value Partners, LP
Large shareholder
|
165,007
+6.4%
0.91
USD 149,876
|
165,007
+6.4%
|
0.91
|
USD 149,876
|
|
|
2009-10-23 |
2009-10-21 |
S
Sale
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Large shareholder
|
2,692,493
-89.0%
0.91
USD 2,450,169
|
2,692,493
-89.0%
|
0.91
|
USD 2,450,169
|
|
|
2009-10-23 |
2009-10-21 |
S
Sale
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Large shareholder
|
777,408
-20.4%
0.91
USD 707,441
|
777,408
-20.4%
|
0.91
|
USD 707,441
|
|
|
2009-10-23 |
2009-10-21 |
S
Sale
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Large shareholder
|
1,136,494
-23.0%
0.91
USD 1,034,210
|
1,136,494
-23.0%
|
0.91
|
USD 1,034,210
|
|
|
2009-02-12 |
2008-12-17 |
S
Sale
|
FREIMAN PAUL E
Former officer and director
|
66
-0.4%
0.21
USD 14
|
66
-0.4%
|
0.21
|
USD 14
|
|
|
2009-02-12 |
2008-12-17 |
S
Sale
|
FREIMAN PAUL E
Former officer and director
|
400
-2.6%
0.21
USD 84
|
400
-2.6%
|
0.21
|
USD 84
|
|
|
2009-02-12 |
2008-12-16 |
S
Sale
|
FREIMAN PAUL E
Former officer and director
|
30
-0.2%
0.58
USD 17
|
30
-0.2%
|
0.58
|
USD 17
|
|
|
2009-02-12 |
2008-12-16 |
S
Sale
|
FREIMAN PAUL E
Former officer and director
|
970
-5.9%
0.56
USD 543
|
970
-5.9%
|
0.56
|
USD 543
|
|
|
2009-02-12 |
2008-12-10 |
S
Sale
|
FREIMAN PAUL E
Former officer and director
|
1,000
-5.8%
0.61
USD 610
|
1,000
-5.8%
|
0.61
|
USD 610
|
|
|
2008-11-18 |
2008-11-14 |
S
Sale
|
J P MORGAN CHASE & CO
Large shareholder
|
2,962,340
-100.0%
0.48
USD 1,410,666
|
2,962,340
-100.0%
|
0.48
|
USD 1,410,666
|
|
|
2008-11-14 |
2008-11-12 |
B
Purchase
|
Wasiewski Warren W
Vice President, CMO
Officer
|
10,000
+inf%
0.66
USD 6,600
|
10,000
+inf%
|
0.66
|
USD 6,600
|
|
|
2008-11-13 |
2008-11-11 |
B
Purchase
|
Fletcher William A
Non-Executive Director
|
10,000
+17.1%
0.66
USD 6,600
|
10,000
+17.1%
|
0.66
|
USD 6,600
|
|
|
2008-10-30 |
2008-10-29 |
B
Purchase
|
Fletcher William A
Non-Executive Director
|
5,000
+9.3%
0.65
USD 3,250
|
5,000
+9.3%
|
0.65
|
USD 3,250
|
|
|
2008-10-30 |
2008-10-28 |
B
Purchase
|
Fletcher William A
Non-Executive Director
|
10,000
+22.9%
0.70
USD 7,000
|
10,000
+22.9%
|
0.70
|
USD 7,000
|
|
|
2008-10-23 |
2008-10-22 |
B
Purchase
|
LOAR MATTHEW M
VP and Chief Financial Officer
Officer
|
25,000
+inf%
0.75
USD 18,750
|
25,000
+inf%
|
0.75
|
USD 18,750
|
|
|
2008-10-16 |
2008-10-15 |
B
Purchase
|
STUPPIN JOHN B
Non-Executive Director
|
1,000
+0.6%
0.87
USD 870
|
1,000
+0.6%
|
0.87
|
USD 870
|
|
|
2008-10-16 |
2008-10-15 |
B
Purchase
|
STUPPIN JOHN B
Non-Executive Director
|
9,000
+5.5%
0.85
USD 7,650
|
9,000
+5.5%
|
0.85
|
USD 7,650
|
|
|
2008-10-20 |
2008-10-08 |
S
Sale
|
J P MORGAN CHASE & CO
Large shareholder
|
158,300
-5.1%
0.44
USD 69,652
|
158,300
-5.1%
|
0.44
|
USD 69,652
|
|
|
2008-10-20 |
2008-10-07 |
S
Sale
|
J P MORGAN CHASE & CO
Large shareholder
|
211,100
-6.3%
0.50
USD 105,550
|
211,100
-6.3%
|
0.50
|
USD 105,550
|
|
|
2008-10-20 |
2008-10-06 |
S
Sale
|
J P MORGAN CHASE & CO
Large shareholder
|
3,304
-0.1%
0.47
USD 1,553
|
3,304
-0.1%
|
0.47
|
USD 1,553
|
|
|
2008-10-20 |
2008-10-03 |
S
Sale
|
J P MORGAN CHASE & CO
Large shareholder
|
17,900
-0.5%
0.55
USD 9,845
|
17,900
-0.5%
|
0.55
|
USD 9,845
|
|
|
2008-10-20 |
2008-10-02 |
S
Sale
|
J P MORGAN CHASE & CO
Large shareholder
|
41,550
-1.2%
0.53
USD 22,022
|
41,550
-1.2%
|
0.53
|
USD 22,022
|
|
|
2008-10-20 |
2008-10-01 |
S
Sale
|
J P MORGAN CHASE & CO
Large shareholder
|
24,320
-0.7%
0.66
USD 16,051
|
24,320
-0.7%
|
0.66
|
USD 16,051
|
|
|
2008-10-20 |
2008-09-30 |
S
Sale
|
J P MORGAN CHASE & CO
Large shareholder
|
2,700
-0.1%
0.65
USD 1,755
|
2,700
-0.1%
|
0.65
|
USD 1,755
|
|
|
2008-10-20 |
2008-09-29 |
S
Sale
|
J P MORGAN CHASE & CO
Large shareholder
|
29,150
-0.8%
0.63
USD 18,365
|
29,150
-0.8%
|
0.63
|
USD 18,365
|
|
|
2008-10-20 |
2008-09-26 |
S
Sale
|
J P MORGAN CHASE & CO
Large shareholder
|
71,100
-2.0%
0.72
USD 51,192
|
71,100
-2.0%
|
0.72
|
USD 51,192
|
|
|
2008-10-20 |
2008-09-25 |
S
Sale
|
J P MORGAN CHASE & CO
Large shareholder
|
163,567
-4.4%
0.78
USD 127,582
|
163,567
-4.4%
|
0.78
|
USD 127,582
|
|
|
2008-10-20 |
2008-09-24 |
S
Sale
|
J P MORGAN CHASE & CO
Large shareholder
|
38,423
-1.0%
0.89
USD 34,196
|
38,423
-1.0%
|
0.89
|
USD 34,196
|
|
|
2008-01-03 |
2007-12-31 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
50,000
+1.0%
2.88
USD 144,000
|
50,000
+1.0%
|
2.88
|
USD 144,000
|
|
|
2008-01-02 |
2007-12-31 |
S
Sale
|
KASPER F VAN
Non-Executive Director
|
100
-0.2%
2.91
USD 291
|
100
-0.2%
|
2.91
|
USD 291
|
|
|
2008-01-02 |
2007-12-31 |
S
Sale
|
KASPER F VAN
Non-Executive Director
|
14,119
-24.4%
2.90
USD 40,945
|
14,119
-24.4%
|
2.90
|
USD 40,945
|
|
|
2008-01-02 |
2007-12-31 |
S
Sale
|
KASPER F VAN
Non-Executive Director
|
5,780
-9.1%
2.92
USD 16,878
|
5,780
-9.1%
|
2.92
|
USD 16,878
|
|
|
2007-12-28 |
2007-12-28 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
16,400
+0.3%
2.94
USD 48,186
|
16,400
+0.3%
|
2.94
|
USD 48,186
|
|
|
2007-12-28 |
2007-12-27 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
24,800
+0.5%
2.96
USD 73,443
|
24,800
+0.5%
|
2.96
|
USD 73,443
|
|
|
2007-12-28 |
2007-12-26 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
7,200
+0.1%
3.00
USD 21,599
|
7,200
+0.1%
|
3.00
|
USD 21,599
|
|
|
2007-12-21 |
2007-12-20 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
6,100
+0.1%
3.00
USD 18,300
|
6,100
+0.1%
|
3.00
|
USD 18,300
|
|
|
2007-12-21 |
2007-12-19 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
26,700
+0.6%
3.00
USD 80,100
|
26,700
+0.6%
|
3.00
|
USD 80,100
|
|
|
2007-12-18 |
2007-12-18 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
50,000
+1.0%
3.00
USD 150,000
|
50,000
+1.0%
|
3.00
|
USD 150,000
|
|
|
2007-12-18 |
2007-12-17 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
25,000
+0.5%
3.00
USD 75,000
|
25,000
+0.5%
|
3.00
|
USD 75,000
|
|
|
2007-12-18 |
2007-12-14 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
50,000
+1.1%
2.99
USD 149,500
|
50,000
+1.1%
|
2.99
|
USD 149,500
|
|
|
2007-12-18 |
2007-12-13 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
25,000
+0.5%
3.00
USD 75,000
|
25,000
+0.5%
|
3.00
|
USD 75,000
|
|
|
2007-12-18 |
2007-12-12 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
50,000
+1.1%
3.00
USD 150,000
|
50,000
+1.1%
|
3.00
|
USD 150,000
|
|
|
2007-12-11 |
2007-12-11 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
50,000
+1.1%
3.00
USD 150,000
|
50,000
+1.1%
|
3.00
|
USD 150,000
|
|
|
2007-12-11 |
2007-12-10 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
101,300
+2.3%
2.98
USD 301,651
|
101,300
+2.3%
|
2.98
|
USD 301,651
|
|
|
2007-12-11 |
2007-12-07 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
52,000
+1.2%
3.00
USD 155,901
|
52,000
+1.2%
|
3.00
|
USD 155,901
|
|
|
2007-12-05 |
2007-12-03 |
B
Purchase
|
STUPPIN JOHN B
Non-Executive Director
|
7,000
+4.4%
3.26
USD 22,820
|
7,000
+4.4%
|
3.26
|
USD 22,820
|
|
|
2007-12-05 |
2007-12-03 |
B
Purchase
|
STUPPIN JOHN B
Non-Executive Director
|
7,800
+5.2%
3.32
USD 25,896
|
7,800
+5.2%
|
3.32
|
USD 25,896
|
|
|
2007-12-05 |
2007-12-03 |
B
Purchase
|
STUPPIN JOHN B
Non-Executive Director
|
200
+0.1%
3.31
USD 662
|
200
+0.1%
|
3.31
|
USD 662
|
|
|
2007-12-05 |
2007-12-03 |
B
Purchase
|
STUPPIN JOHN B
Non-Executive Director
|
2,000
+1.4%
3.30
USD 6,600
|
2,000
+1.4%
|
3.30
|
USD 6,600
|
|
|
2007-12-05 |
2007-12-03 |
B
Purchase
|
FREIMAN PAUL E
President and CEO
Executive Director
|
3,000
+20.9%
3.30
USD 9,900
|
3,000
+20.9%
|
3.30
|
USD 9,900
|
|
|
2007-11-29 |
2007-11-28 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
336,000
+8.2%
2.71
USD 910,560
|
336,000
+8.2%
|
2.71
|
USD 910,560
|
|
|
2007-11-29 |
2007-11-27 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
116,303
+2.9%
2.70
USD 314,018
|
116,303
+2.9%
|
2.70
|
USD 314,018
|
|
|
2007-11-26 |
2007-11-26 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
20,500
+0.5%
2.58
USD 52,890
|
20,500
+0.5%
|
2.58
|
USD 52,890
|
|
|
2007-11-26 |
2007-11-21 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
188,988
+5.0%
2.40
USD 453,571
|
188,988
+5.0%
|
2.40
|
USD 453,571
|
|
|
2007-11-19 |
2007-11-19 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
23,200
+0.6%
2.49
USD 57,875
|
23,200
+0.6%
|
2.49
|
USD 57,875
|
|
|
2007-11-19 |
2007-11-15 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
29,700
+0.8%
2.46
USD 73,166
|
29,700
+0.8%
|
2.46
|
USD 73,166
|
|
|
2007-11-15 |
2007-11-14 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
8,600
+0.2%
2.40
USD 20,640
|
8,600
+0.2%
|
2.40
|
USD 20,640
|
|
|
2007-11-15 |
2007-11-13 |
B
Purchase
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
57,000
+1.6%
2.39
USD 136,127
|
57,000
+1.6%
|
2.39
|
USD 136,127
|
|
|
2008-06-26 |
2007-11-06 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
29,000
+0.6%
2.43
USD 70,392
|
29,000
+0.6%
|
2.43
|
USD 70,392
|
|
|
2008-06-26 |
2007-11-06 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
7,000
+0.1%
2.43
USD 16,991
|
7,000
+0.1%
|
2.43
|
USD 16,991
|
|
|
2008-06-26 |
2007-11-06 |
B
Purchase
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
11,000
+0.2%
2.43
USD 26,700
|
11,000
+0.2%
|
2.43
|
USD 26,700
|
|
|
2007-11-06 |
2007-11-02 |
B
Purchase
|
STUPPIN JOHN B
Non-Executive Director
|
43,600
+42.0%
2.75
USD 119,900
|
43,600
+42.0%
|
2.75
|
USD 119,900
|
|
|
2007-11-06 |
2007-11-02 |
B
Purchase
|
Fletcher William A
Non-Executive Director
|
43,600
+inf%
2.75
USD 119,900
|
43,600
+inf%
|
2.75
|
USD 119,900
|
|
|
2007-11-06 |
2007-11-02 |
B
Purchase
|
COHEN ABRAHAM E
Non-Executive Director
|
43,600
+58.1%
2.75
USD 119,900
|
43,600
+58.1%
|
2.75
|
USD 119,900
|
|
|
2007-11-06 |
2007-11-02 |
B
Purchase
|
SOFAER ABRAHAM D
Non-Executive Director
|
43,600
+64.8%
2.75
USD 119,900
|
43,600
+64.8%
|
2.75
|
USD 119,900
|
|
|
2007-11-01 |
2007-10-31 |
B
Purchase
|
CARLSON CRAIG W
VP and Chief Financial Officer
Officer
|
1,000
+inf%
2.62
USD 2,620
|
1,000
+inf%
|
2.62
|
USD 2,620
|
|
|
2007-11-13 |
2007-10-30 |
B
Purchase
|
Levy David E
VP of Clinical Development
Officer
|
10,000
+321.0%
2.63
USD 26,300
|
10,000
+321.0%
|
2.63
|
USD 26,300
|
|
|
2007-02-23 |
2007-02-22 |
S
Sale
|
FREIMAN PAUL E
President and CEO
Executive Director
|
64,563
-39.1%
2.61
USD 168,535
|
64,563
-39.1%
|
2.61
|
USD 168,535
|
|
|
2007-02-23 |
2007-02-21 |
S
Sale
|
FREIMAN PAUL E
President and CEO
Executive Director
|
10,437
-15.8%
2.73
USD 28,474
|
10,437
-15.8%
|
2.73
|
USD 28,474
|
|
|
2007-02-23 |
2007-02-21 |
S
Sale
|
FREIMAN PAUL E
President and CEO
Executive Director
|
25,000
-31.0%
2.73
USD 68,205
|
25,000
-31.0%
|
2.73
|
USD 68,205
|
|
|
2007-02-15 |
2007-02-14 |
S
Sale
|
ELIOT THEODORE
Non-Executive Director
|
19,300
-51.3%
2.65
USD 51,145
|
19,300
-51.3%
|
2.65
|
USD 51,145
|
|
