|
2008-12-11 |
2008-12-08 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
19,418
-0.5%
0.59
USD 11,457
|
19,418
-0.5%
|
0.59
|
USD 11,457
|
|
|
2008-12-11 |
2008-12-08 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
22,797
-0.5%
0.59
USD 13,450
|
22,797
-0.5%
|
0.59
|
USD 13,450
|
|
|
2008-12-11 |
2008-12-05 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
449,523
-9.9%
0.59
USD 265,219
|
449,523
-9.9%
|
0.59
|
USD 265,219
|
|
|
2008-12-11 |
2008-12-05 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
527,702
-9.9%
0.59
USD 311,344
|
527,702
-9.9%
|
0.59
|
USD 311,344
|
|
|
2007-11-30 |
2007-11-28 |
B
Purchase
|
FLEMING JONATHAN
Non-Executive Director
|
990,066
+38.0%
0.55
USD 544,536
|
990,066
+38.0%
|
0.55
|
USD 544,536
|
|
|
2007-11-30 |
2007-11-28 |
B
Purchase
|
FLEMING JONATHAN
Non-Executive Director
|
9,934
+38.0%
0.55
USD 5,464
|
9,934
+38.0%
|
0.55
|
USD 5,464
|
|
|
2007-11-06 |
2007-11-05 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
11,868
-0.3%
0.98
USD 11,631
|
11,868
-0.3%
|
0.98
|
USD 11,631
|
|
|
2007-11-06 |
2007-11-05 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
13,932
-0.3%
0.98
USD 13,653
|
13,932
-0.3%
|
0.98
|
USD 13,653
|
|
|
2007-11-06 |
2007-11-02 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
162,840
-3.5%
1.02
USD 166,895
|
162,840
-3.5%
|
1.02
|
USD 166,895
|
|
|
2007-11-06 |
2007-11-02 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
191,160
-3.5%
1.02
USD 195,920
|
191,160
-3.5%
|
1.02
|
USD 195,920
|
|
|
2007-10-24 |
2007-10-23 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
108,000
-1.9%
0.91
USD 98,215
|
108,000
-1.9%
|
0.91
|
USD 98,215
|
|
|
2007-10-24 |
2007-10-22 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
92,000
-1.9%
0.91
USD 83,665
|
92,000
-1.9%
|
0.91
|
USD 83,665
|
|
|
2007-10-24 |
2007-10-22 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
191,360
-3.8%
0.95
USD 181,677
|
191,360
-3.8%
|
0.95
|
USD 181,677
|
|
|
2007-10-24 |
2007-10-22 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
224,640
-3.8%
0.95
USD 213,273
|
224,640
-3.8%
|
0.95
|
USD 213,273
|
|
|
2007-10-22 |
2007-10-17 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
41,400
-0.8%
0.97
USD 40,158
|
41,400
-0.8%
|
0.97
|
USD 40,158
|
|
|
2007-10-22 |
2007-10-17 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
353,740
-6.6%
0.94
USD 334,107
|
353,740
-6.6%
|
0.94
|
USD 334,107
|
|
|
2007-10-22 |
2007-10-17 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
48,600
-0.8%
0.97
USD 47,142
|
48,600
-0.8%
|
0.97
|
USD 47,142
|
|
|
2007-10-22 |
2007-10-17 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
415,260
-6.6%
0.94
USD 392,213
|
415,260
-6.6%
|
0.94
|
USD 392,213
|
|
|
2007-10-17 |
2007-10-16 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
177,495
-3.2%
1.01
USD 180,051
|
177,495
-3.2%
|
1.01
|
USD 180,051
|
|
|
2007-10-17 |
2007-10-16 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
138,000
-2.4%
1.11
USD 153,235
|
138,000
-2.4%
|
1.11
|
USD 153,235
|
|
|
2007-10-17 |
2007-10-16 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
208,364
-3.2%
1.01
USD 211,364
|
208,364
-3.2%
|
1.01
|
USD 211,364
|
|
|
2007-10-17 |
2007-10-16 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
162,000
-2.4%
0.98
USD 158,760
|
162,000
-2.4%
|
0.98
|
USD 158,760
|
|
|
2007-10-17 |
2007-10-15 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
619,397
-9.8%
0.98
USD 607,009
|
619,397
-9.8%
|
0.98
|
USD 607,009
|
|
|
2007-10-17 |
2007-10-15 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
15,686
-0.2%
1.10
USD 17,273
|
15,686
-0.2%
|
1.10
|
USD 17,273
|
|
|
2007-10-17 |
2007-10-15 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
727,119
-9.8%
1.11
USD 807,393
|
727,119
-9.8%
|
1.11
|
USD 807,393
|
|
|
2007-10-17 |
2007-10-15 |
S
Sale
|
GREAT POINT PARTNERS LLC
Large shareholder
|
18,484
-0.2%
1.10
USD 20,364
|
18,484
-0.2%
|
1.10
|
USD 20,364
|
|
|
2007-09-18 |
2007-09-14 |
S
Sale
|
MPM BioVentures IV QP LP
Large shareholder
|
27,600
-0.2%
2.10
USD 57,960
|
27,600
-0.2%
|
2.10
|
USD 57,960
|
|
|
2007-09-18 |
2007-09-14 |
S
Sale
|
KAILIAN VAUGHN M
Non-Executive Director
Large shareholder
|
27,600
-0.2%
2.10
USD 57,960
|
27,600
-0.2%
|
2.10
|
USD 57,960
|
|
|
2007-09-14 |
2007-09-13 |
S
Sale
|
KAILIAN VAUGHN M
Non-Executive Director
Large shareholder
|
62,180
-0.4%
2.12
USD 132,120
|
62,180
-0.4%
|
2.12
|
USD 132,120
|
|
|
2007-09-14 |
2007-09-13 |
S
Sale
|
MPM BioVentures IV QP LP
Large shareholder
|
62,180
-0.4%
2.12
USD 132,120
|
62,180
-0.4%
|
2.12
|
USD 132,120
|
|
|
2007-09-14 |
2007-09-12 |
S
Sale
|
KAILIAN VAUGHN M
Non-Executive Director
Large shareholder
|
10,000
-0.1%
2.16
USD 21,611
|
10,000
-0.1%
|
2.16
|
USD 21,611
|
|
|
2007-09-14 |
2007-09-12 |
S
Sale
|
MPM BioVentures IV QP LP
Large shareholder
|
10,000
-0.1%
2.16
USD 21,611
|
10,000
-0.1%
|
2.16
|
USD 21,611
|
|
|
2007-01-05 |
2006-12-18 |
B
Purchase
|
KAILIAN VAUGHN M
Non-Executive Director
Large shareholder
|
2,315,151
+25.5%
1.11
USD 2,569,818
|
2,315,151
+25.5%
|
1.11
|
USD 2,569,818
|
|
|
2007-01-05 |
2006-12-18 |
B
Purchase
|
MPM BioVentures IV LP
Large shareholder
|
2,315,151
+25.5%
1.11
USD 2,569,818
|
2,315,151
+25.5%
|
1.11
|
USD 2,569,818
|
|
|
2006-10-18 |
2006-10-16 |
B
Purchase
|
EVNIN ANTHONY B
Non-Executive Director
|
516,977
+42.6%
1.11
USD 573,844
|
516,977
+42.6%
|
1.11
|
USD 573,844
|
|
|
2006-10-18 |
2006-10-16 |
B
Purchase
|
EVNIN ANTHONY B
Non-Executive Director
|
359,255
+41.8%
1.11
USD 398,773
|
359,255
+41.8%
|
1.11
|
USD 398,773
|
|
|
2006-10-18 |
2006-10-16 |
B
Purchase
|
EVNIN ANTHONY B
Non-Executive Director
|
87,623
+47.6%
1.11
USD 97,262
|
87,623
+47.6%
|
1.11
|
USD 97,262
|
|
|
2006-10-18 |
2006-10-16 |
B
Purchase
|
SULAT JAMES R
President & CEO
Executive Director
|
87,623
+52.2%
1.11
USD 97,262
|
87,623
+52.2%
|
1.11
|
USD 97,262
|
|
|
2006-10-18 |
2006-10-16 |
B
Purchase
|
MEYERS MICHAEL E
Non-Executive Director
|
17,525
+66.6%
1.11
USD 19,453
|
17,525
+66.6%
|
1.11
|
USD 19,453
|
|
|
2006-06-12 |
2006-06-09 |
S
Sale
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
12,000
-0.3%
1.76
USD 21,140
|
12,000
-0.3%
|
1.76
|
USD 21,140
|
|
|
2006-06-12 |
2006-06-08 |
S
Sale
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
3,567
-0.1%
1.66
USD 5,921
|
3,567
-0.1%
|
1.66
|
USD 5,921
|
|
|
2006-06-12 |
2006-06-08 |
S
Sale
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
14,300
-0.4%
1.78
USD 25,470
|
14,300
-0.4%
|
1.78
|
USD 25,470
|
|
|
2006-06-12 |
2006-06-08 |
S
Sale
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
196,500
-5.0%
1.67
USD 328,587
|
196,500
-5.0%
|
1.67
|
USD 328,587
|
|
|
2006-06-06 |
2006-06-05 |
B
Purchase
|
SULAT JAMES R
President & CEO
Executive Director
|
10,000
+6.3%
1.75
USD 17,500
|
10,000
+6.3%
|
1.75
|
USD 17,500
|
|
|
2006-06-05 |
2006-06-01 |
S
Sale
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
15,600
-0.4%
1.86
USD 29,016
|
15,600
-0.4%
|
1.86
|
USD 29,016
|
|
|
2006-06-05 |
2006-06-01 |
S
Sale
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
3,400
-0.1%
1.91
USD 6,496
|
3,400
-0.1%
|
1.91
|
USD 6,496
|
|
|
2006-05-17 |
2006-05-15 |
S
Sale
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
14,400
-0.4%
2.00
USD 28,793
|
14,400
-0.4%
|
2.00
|
USD 28,793
|
|
|
2006-05-15 |
2006-05-12 |
S
Sale
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
24,000
-0.6%
2.02
USD 48,439
|
24,000
-0.6%
|
2.02
|
USD 48,439
|
|
|
2006-05-15 |
2006-05-11 |
S
Sale
|
MARXE AUSTIN W & GREENHOUSE DAVID M
Large shareholder
|
112,000
-2.7%
2.15
USD 240,509
|
112,000
-2.7%
|
2.15
|
USD 240,509
|
|
|
2005-09-27 |
2005-09-23 |
B
Purchase
|
MARDUEL ALIX
No longer a Director
|
789,474
0.00
USD 0
|
789,474
|
0.00
|
USD 0
|
|
|
2005-09-26 |
2005-09-23 |
B
Purchase
|
EVNIN ANTHONY B
Non-Executive Director
|
465,789
+62.3%
1.90
USD 884,999
|
465,789
+62.3%
|
1.90
|
USD 884,999
|
|
|
2005-09-26 |
2005-09-23 |
B
Purchase
|
EVNIN ANTHONY B
Non-Executive Director
|
323,684
+60.4%
1.90
USD 615,000
|
323,684
+60.4%
|
1.90
|
USD 615,000
|
|
|
2005-09-26 |
2005-09-23 |
B
Purchase
|
EVNIN ANTHONY B
Non-Executive Director
|
184,211
+inf%
1.90
USD 350,001
|
184,211
+inf%
|
1.90
|
USD 350,001
|
|
|
2005-09-23 |
2005-09-23 |
B
Purchase
|
SULAT JAMES R
President & CEO
Executive Director
|
157,895
+inf%
1.90
USD 300,001
|
157,895
+inf%
|
1.90
|
USD 300,001
|
|
|
2005-09-23 |
2005-09-23 |
B
Purchase
|
FLEMING JONATHAN
Non-Executive Director
Large shareholder
|
26,142
+inf%
1.90
USD 49,670
|
26,142
+inf%
|
1.90
|
USD 49,670
|
|
|
2005-09-23 |
2005-09-23 |
B
Purchase
|
FLEMING JONATHAN
Non-Executive Director
Large shareholder
|
2,605,437
+inf%
1.90
USD 4,950,330
|
2,605,437
+inf%
|
1.90
|
USD 4,950,330
|
|
|
2005-09-23 |
2005-09-23 |
B
Purchase
|
FLEMING JONATHAN
Non-Executive Director
Large shareholder
|
526,316
+69.5%
1.90
USD 1,000,000
|
526,316
+69.5%
|
1.90
|
USD 1,000,000
|
|
|
2005-09-23 |
2005-09-23 |
B
Purchase
|
KRIEBEL ROBERT I
Non-Executive Director
|
5,000
+inf%
1.90
USD 9,500
|
5,000
+inf%
|
1.90
|
USD 9,500
|
|
|
2005-09-23 |
2005-09-23 |
B
Purchase
|
MEYERS MICHAEL E
Non-Executive Director
|
26,316
+inf%
1.90
USD 50,000
|
26,316
+inf%
|
1.90
|
USD 50,000
|
|
|
2005-09-23 |
2005-09-23 |
B
Purchase
|
SCULLION TONY
President & CEO
Executive Director
|
39,474
+28.5%
1.90
USD 75,001
|
39,474
+28.5%
|
1.90
|
USD 75,001
|
|
|
2005-09-23 |
2005-09-23 |
B
Purchase
|
Lowe David A
Chief Scientific Officer
Executive Director
|
26,316
+inf%
1.90
USD 50,000
|
26,316
+inf%
|
1.90
|
USD 50,000
|
|
|
2005-09-23 |
2005-09-23 |
B
Purchase
|
GILBERT WALTER PHD
Non-Executive Director
|
52,632
+39.5%
1.90
USD 100,001
|
52,632
+39.5%
|
1.90
|
USD 100,001
|
|
|
2005-03-16 |
2005-03-14 |
PS
Planned sale
|
SCULLION TONY
Chief Executive Officer
Executive Director
|
300
-0.3%
5.00
USD 1,500
|
300
-0.3%
|
5.00
|
USD 1,500
|
|
|
2005-03-09 |
2005-03-07 |
PS
Planned sale
|
SCULLION TONY
Chief Executive Officer
Executive Director
|
8,750
-7.8%
5.01
USD 43,870
|
8,750
-7.8%
|
5.01
|
USD 43,870
|
|
|
2005-03-03 |
2005-03-01 |
PS
Planned sale
|
SCULLION TONY
Chief Executive Officer
Executive Director
|
8,750
-8.2%
5.01
USD 43,806
|
8,750
-8.2%
|
5.01
|
USD 43,806
|
|
|
2005-02-24 |
2005-02-22 |
PS
Planned sale
|
SCULLION TONY
Chief Executive Officer
Executive Director
|
8,750
-8.8%
5.00
USD 43,750
|
8,750
-8.8%
|
5.00
|
USD 43,750
|
|
|
2005-02-15 |
2005-02-14 |
PS
Planned sale
|
SCULLION TONY
Chief Executive Officer
Executive Director
|
8,750
-8.8%
5.01
USD 43,870
|
8,750
-8.8%
|
5.01
|
USD 43,870
|
|
|
2005-02-09 |
2005-02-07 |
PS
Planned sale
|
SCULLION TONY
Chief Executive Officer
Executive Director
|
8,750
-8.8%
5.00
USD 43,750
|
8,750
-8.8%
|
5.00
|
USD 43,750
|
|
|
2005-02-04 |
2005-02-02 |
PS
Planned sale
|
SCULLION TONY
Chief Executive Officer
Executive Director
|
8,750
-8.8%
5.00
USD 43,750
|
8,750
-8.8%
|
5.00
|
USD 43,750
|
|
|
2005-01-26 |
2005-01-25 |
PS
Planned sale
|
SCULLION TONY
Chief Executive Officer
Executive Director
|
2,450
-2.6%
5.00
USD 12,250
|
2,450
-2.6%
|
5.00
|
USD 12,250
|
|
|
2005-01-26 |
2005-01-24 |
PS
Planned sale
|
SCULLION TONY
Chief Executive Officer
Executive Director
|
6,300
-6.5%
5.03
USD 31,675
|
6,300
-6.5%
|
5.03
|
USD 31,675
|
|
|
2005-01-20 |
2005-01-18 |
PS
Planned sale
|
SCULLION TONY
Chief Executive Officer
Executive Director
|
8,750
-8.8%
5.02
USD 43,954
|
8,750
-8.8%
|
5.02
|
USD 43,954
|
|
|
2005-01-12 |
2005-01-11 |
PS
Planned sale
|
SCULLION TONY
Chief Executive Officer
Executive Director
|
4,000
-4.2%
5.41
USD 21,625
|
4,000
-4.2%
|
5.41
|
USD 21,625
|
|
|
2005-01-12 |
2005-01-10 |
PS
Planned sale
|
SCULLION TONY
Chief Executive Officer
Executive Director
|
4,750
-5.0%
5.48
USD 26,042
|
4,750
-5.0%
|
5.48
|
USD 26,042
|
|
|
2005-01-05 |
2005-01-05 |
PS
Planned sale
|
SCULLION TONY
Chief Executive Officer
Executive Director
|
1,750
-1.9%
5.44
USD 9,520
|
1,750
-1.9%
|
5.44
|
USD 9,520
|
|
