|
2025-01-07 |
2025-01-06 |
PS
Planned sale
|
Reumuth Mary
CHIEF FINANCIAL OFFICER
Officer
|
1,706
-2.4%
7.63
USD 13,017
|
1,706
-2.4%
|
7.63
|
USD 13,017
|
|
|
2025-01-07 |
2025-01-06 |
PS
Planned sale
|
Kharabi Darius
CHIEF BUSINESS OFFICER
Officer
|
2,021
-2.9%
7.63
USD 15,420
|
2,021
-2.9%
|
7.63
|
USD 15,420
|
|
|
2025-01-07 |
2025-01-06 |
PS
Planned sale
|
Brazzell Romulus K
SEE REMARKS
Officer
|
2,446
-2.6%
7.63
USD 18,663
|
2,446
-2.6%
|
7.63
|
USD 18,663
|
|
|
2025-01-07 |
2025-01-06 |
PS
Planned sale
|
Iwicki Mark T
CHIEF EXECUTIVE OFFICER
Executive Director
|
5,779
-2.0%
7.63
USD 44,094
|
5,779
-2.0%
|
7.63
|
USD 44,094
|
|
|
2024-12-31 |
2024-12-30 |
B
Purchase
|
BAKER BROS. ADVISORS LP
Large shareholder
|
279,939
+34.8%
6.44
USD 1,802,807
|
279,939
+34.8%
|
6.44
|
USD 1,802,807
|
|
|
2024-12-31 |
2024-12-30 |
B
Purchase
|
BAKER BROS. ADVISORS LP
Large shareholder
|
30,620
+34.8%
6.44
USD 197,193
|
30,620
+34.8%
|
6.44
|
USD 197,193
|
|
|
2024-06-27 |
2024-06-26 |
PS
Planned sale
|
Iwicki Mark T
CHIEF EXECUTIVE OFFICER
Executive Director
|
15,168
-5.4%
4.75
USD 72,048
|
15,168
-5.4%
|
4.75
|
USD 72,048
|
|
|
2024-06-27 |
2024-06-26 |
PS
Planned sale
|
Reumuth Mary
CHIEF FINANCIAL OFFICER
Officer
|
4,163
-6.5%
4.75
USD 19,774
|
4,163
-6.5%
|
4.75
|
USD 19,774
|
|
|
2024-06-27 |
2024-06-26 |
PS
Planned sale
|
Bazemore Todd
SEE REMARKS
Officer
|
4,653
-5.3%
4.75
USD 22,102
|
4,653
-5.3%
|
4.75
|
USD 22,102
|
|
|
2024-06-27 |
2024-06-26 |
PS
Planned sale
|
Kharabi Darius
CHIEF BUSINESS OFFICER
Officer
|
5,158
-7.9%
4.75
USD 24,501
|
5,158
-7.9%
|
4.75
|
USD 24,501
|
|
|
2024-06-27 |
2024-06-26 |
PS
Planned sale
|
Brazzell Romulus K
SEE REMARKS
Officer
|
5,489
-6.1%
4.75
USD 26,073
|
5,489
-6.1%
|
4.75
|
USD 26,073
|
|
|
2024-06-03 |
2024-05-31 |
PS
Planned sale
|
Kharabi Darius
CHIEF BUSINESS OFFICER
Officer
|
231
-0.4%
6.09
USD 1,407
|
231
-0.4%
|
6.09
|
USD 1,407
|
|
|
2024-06-03 |
2024-05-31 |
PS
Planned sale
|
Iwicki Mark T
CHIEF EXECUTIVE OFFICER
Executive Director
|
7,392
-2.6%
6.09
USD 45,017
|
7,392
-2.6%
|
6.09
|
USD 45,017
|
|
|
2024-06-03 |
2024-05-31 |
PS
Planned sale
|
Brazzell Romulus K
SEE REMARKS
Officer
|
2,002
-2.2%
6.09
USD 12,192
|
2,002
-2.2%
|
6.09
|
USD 12,192
|
|
|
2024-06-03 |
2024-05-31 |
PS
Planned sale
|
Bazemore Todd
SEE REMARKS
Officer
|
2,093
-2.3%
6.09
USD 12,746
|
2,093
-2.3%
|
6.09
|
USD 12,746
|
|
|
2024-06-03 |
2024-05-31 |
PS
Planned sale
|
Reumuth Mary
CHIEF FINANCIAL OFFICER
Officer
|
1,786
-2.7%
6.09
USD 10,877
|
1,786
-2.7%
|
6.09
|
USD 10,877
|
|
|
2024-01-05 |
2024-01-04 |
PS
Planned sale
|
Brazzell Romulus K
SEE REMARKS
Officer
|
1,617
-1.7%
6.74
USD 10,899
|
1,617
-1.7%
|
6.74
|
USD 10,899
|
|
|
2024-01-05 |
2024-01-04 |
PS
Planned sale
|
Trachtenberg Eric
SEE REMARKS
Officer
|
1,227
-1.8%
6.74
USD 8,270
|
1,227
-1.8%
|
6.74
|
USD 8,270
|
|
|
2024-01-05 |
2024-01-04 |
PS
Planned sale
|
Reumuth Mary
CHIEF FINANCIAL OFFICER
Officer
|
1,227
-1.8%
6.74
USD 8,270
|
1,227
-1.8%
|
6.74
|
USD 8,270
|
|
|
2024-01-05 |
2024-01-04 |
PS
Planned sale
|
Kharabi Darius
CHIEF BUSINESS OFFICER
Officer
|
1,385
-2.1%
6.73
USD 9,321
|
1,385
-2.1%
|
6.73
|
USD 9,321
|
|
|
2024-01-05 |
2024-01-04 |
PS
Planned sale
|
Iwicki Mark T
CHIEF EXECUTIVE OFFICER
Executive Director
|
4,539
-1.6%
6.73
USD 30,547
|
4,539
-1.6%
|
6.73
|
USD 30,547
|
|
|
2023-01-06 |
2023-01-04 |
PS
Planned sale
|
Brazzell Romulus K
SEE REMARKS
Officer
|
73
-0.4%
28.53
USD 2,083
|
73
-0.4%
|
28.53
|
USD 2,083
|
|
|
2023-01-06 |
2023-01-04 |
PS
Planned sale
|
Reumuth Mary
CHIEF FINANCIAL OFFICER
Officer
|
60
-0.5%
28.54
USD 1,712
|
60
-0.5%
|
28.54
|
USD 1,712
|
|
|
2023-01-06 |
2023-01-04 |
PS
Planned sale
|
Iwicki Mark T
CHIEF EXECUTIVE OFFICER
Executive Director
|
198
-0.4%
28.54
USD 5,651
|
198
-0.4%
|
28.54
|
USD 5,651
|
|
|
2023-01-06 |
2023-01-04 |
PS
Planned sale
|
Bazemore Todd
SEE REMARKS
Officer
|
62
-0.4%
28.54
USD 1,769
|
62
-0.4%
|
28.54
|
USD 1,769
|
|
|
2023-01-06 |
2023-01-04 |
PS
Planned sale
|
Trachtenberg Eric
SEE REMARKS
Officer
|
60
-0.5%
28.55
USD 1,713
|
60
-0.5%
|
28.55
|
USD 1,713
|
|
|
2022-10-28 |
2022-10-26 |
PS
Planned sale
|
Iwicki Mark T
CHIEF EXECUTIVE OFFICER
Executive Director
|
561
-11.2%
6.52
USD 3,658
|
561
-11.2%
|
6.52
|
USD 3,658
|
|
|
2022-10-28 |
2022-10-26 |
PS
Planned sale
|
Bazemore Todd
SEE REMARKS
Officer
|
214
-9.3%
6.51
USD 1,393
|
214
-9.3%
|
6.51
|
USD 1,393
|
|
|
2022-10-28 |
2022-10-26 |
PS
Planned sale
|
Brazzell Romulus K
SEE REMARKS
Officer
|
261
-4.3%
6.51
USD 1,699
|
261
-4.3%
|
6.51
|
USD 1,699
|
|
|
2022-10-28 |
2022-10-26 |
PS
Planned sale
|
Reumuth Mary
CHIEF FINANCIAL OFFICER
Officer
|
194
-7.4%
6.51
USD 1,263
|
194
-7.4%
|
6.51
|
USD 1,263
|
|
|
2022-10-28 |
2022-10-26 |
PS
Planned sale
|
Trachtenberg Eric
SEE REMARKS
Officer
|
194
-8.7%
6.52
USD 1,265
|
194
-8.7%
|
6.52
|
USD 1,265
|
|
|
2022-06-29 |
2022-06-27 |
PS
Planned sale
|
Iwicki Mark T
CHIEF EXECUTIVE OFFICER
Executive Director
|
7,975
-3.1%
0.37
USD 2,951
|
7,975
-3.1%
|
0.37
|
USD 2,951
|
|
|
2022-06-29 |
2022-06-27 |
PS
Planned sale
|
Bazemore Todd
SEE REMARKS
Officer
|
3,092
-2.6%
0.37
USD 1,144
|
3,092
-2.6%
|
0.37
|
USD 1,144
|
|
|
2022-06-29 |
2022-06-27 |
PS
Planned sale
|
Brazzell Romulus K
SEE REMARKS
Officer
|
3,144
-1.1%
0.37
USD 1,163
|
3,144
-1.1%
|
0.37
|
USD 1,163
|
|
|
2022-06-29 |
2022-06-27 |
PS
Planned sale
|
Reumuth Mary
CHIEF FINANCIAL OFFICER
Officer
|
2,613
-2.0%
0.37
USD 967
|
2,613
-2.0%
|
0.37
|
USD 967
|
|
|
2022-06-29 |
2022-06-27 |
PS
Planned sale
|
Trachtenberg Eric
SEE REMARKS
Officer
|
2,613
-2.3%
0.37
USD 967
|
2,613
-2.3%
|
0.37
|
USD 967
|
|
|
2022-05-26 |
2022-05-26 |
S
Sale
|
RA CAPITAL MANAGEMENT, L.P.
Large shareholder
|
1,005,686
-12.5%
0.36
USD 365,667
|
1,005,686
-12.5%
|
0.36
|
USD 365,667
|
|
|
2022-05-25 |
2022-05-25 |
S
Sale
|
RA CAPITAL MANAGEMENT, L.P.
Large shareholder
|
1,434,509
-15.1%
0.42
USD 602,494
|
1,434,509
-15.1%
|
0.42
|
USD 602,494
|
|
|
2022-05-25 |
2022-05-24 |
S
Sale
|
RA CAPITAL MANAGEMENT, L.P.
Large shareholder
|
144,805
-1.5%
0.51
USD 73,851
|
144,805
-1.5%
|
0.51
|
USD 73,851
|
|
|
2022-05-25 |
2022-05-23 |
S
Sale
|
RA CAPITAL MANAGEMENT, L.P.
Large shareholder
|
1,250,000
-11.5%
0.65
USD 812,500
|
1,250,000
-11.5%
|
0.65
|
USD 812,500
|
|
|
2022-01-05 |
2022-01-04 |
PS
Planned sale
|
Trachtenberg Eric
SEE REMARKS
Officer
|
2,850
-2.4%
1.30
USD 3,705
|
2,850
-2.4%
|
1.30
|
USD 3,705
|
|
|
2022-01-05 |
2022-01-04 |
PS
Planned sale
|
Bazemore Todd
SEE REMARKS
Officer
|
3,454
-2.8%
1.30
USD 4,490
|
3,454
-2.8%
|
1.30
|
USD 4,490
|
|
|
2022-01-05 |
2022-01-04 |
PS
Planned sale
|
Brazzell Romulus K
SEE REMARKS
Officer
|
3,504
-1.2%
1.30
USD 4,555
|
3,504
-1.2%
|
1.30
|
USD 4,555
|
|
|
2022-01-05 |
2022-01-04 |
PS
Planned sale
|
Iwicki Mark T
CHIEF EXECUTIVE OFFICER
Executive Director
|
9,518
-3.5%
1.30
USD 12,373
|
9,518
-3.5%
|
1.30
|
USD 12,373
|
|
|
2022-01-05 |
2022-01-04 |
PS
Planned sale
|
Reumuth Mary
CHIEF FINANCIAL OFFICER
Officer
|
2,850
-2.1%
1.30
USD 3,705
|
2,850
-2.1%
|
1.30
|
USD 3,705
|
|
|
2021-10-28 |
2021-10-27 |
PS
Planned sale
|
Chen Hongming
CHIEF SCIENTIFIC OFFICER
Officer
|
21,051
-9.3%
1.82
USD 38,313
|
21,051
-9.3%
|
1.82
|
USD 38,313
|
|
|
2021-10-28 |
2021-10-26 |
PS
Planned sale
|
Iwicki Mark T
CHIEF EXECUTIVE OFFICER
Executive Director
|
27,598
-9.3%
1.80
USD 49,676
|
27,598
-9.3%
|
1.80
|
USD 49,676
|
|
|
2021-10-28 |
2021-10-26 |
PS
Planned sale
|
Chen Hongming
CHIEF SCIENTIFIC OFFICER
Officer
|
9,449
-4.0%
1.80
USD 17,008
|
9,449
-4.0%
|
1.80
|
USD 17,008
|
|
|
2021-10-28 |
2021-10-26 |
PS
Planned sale
|
Trachtenberg Eric
SEE REMARKS
Officer
|
9,449
-7.5%
1.80
USD 17,008
|
9,449
-7.5%
|
1.80
|
USD 17,008
|
|
|
2021-10-28 |
2021-10-26 |
PS
Planned sale
|
Brazzell Romulus K
CHIEF MEDICAL OFFICER
Officer
|
12,757
-4.2%
1.80
USD 22,963
|
12,757
-4.2%
|
1.80
|
USD 22,963
|
|
|
2021-10-28 |
2021-10-26 |
PS
Planned sale
|
Bazemore Todd
CHIEF OPERATING OFFICER
Officer
|
12,544
-9.3%
1.80
USD 22,579
|
12,544
-9.3%
|
1.80
|
USD 22,579
|
|
|
2021-10-28 |
2021-10-26 |
PS
Planned sale
|
Reumuth Mary
CHIEF FINANCIAL OFFICER
Officer
|
9,449
-6.5%
1.80
USD 17,008
|
9,449
-6.5%
|
1.80
|
USD 17,008
|
|
|
2021-06-29 |
2021-06-28 |
PS
Planned sale
|
Chen Hongming
CHIEF SCIENTIFIC OFFICER
Officer
|
2,452
-1.0%
5.77
USD 14,148
|
2,452
-1.0%
|
5.77
|
USD 14,148
|
|
|
2021-06-29 |
2021-06-28 |
PS
Planned sale
|
Brazzell Romulus K
CHIEF MEDICAL OFFICER
Officer
|
3,034
-1.0%
5.77
USD 17,506
|
3,034
-1.0%
|
5.77
|
USD 17,506
|
|
|
2021-06-29 |
2021-06-28 |
PS
Planned sale
|
Reumuth Mary
CHIEF FINANCIAL OFFICER
Officer
|
2,452
-1.7%
5.77
USD 14,148
|
2,452
-1.7%
|
5.77
|
USD 14,148
|
|
|
2021-06-29 |
2021-06-28 |
PS
Planned sale
|
Trachtenberg Eric
SEE REMARKS
Officer
|
2,452
-1.9%
5.77
USD 14,148
|
2,452
-1.9%
|
5.77
|
USD 14,148
|
|
|
2020-10-28 |
2020-10-22 |
B
Purchase
|
Bazemore Todd
Chief Operating Officer
Officer
|
40
+2000.0%
7.60
USD 304
|
40
+2000.0%
|
7.60
|
USD 304
|
|
|
2020-10-28 |
2020-06-05 |
B
Purchase
|
Bazemore Todd
Chief Operating Officer
Officer
|
2
+inf%
13.39
USD 27
|
2
+inf%
|
13.39
|
USD 27
|
|
|
2020-03-17 |
2020-03-16 |
B
Purchase
|
Bazemore Todd
Chief Operating Officer
Officer
|
10,000
+inf%
5.75
USD 57,500
|
10,000
+inf%
|
5.75
|
USD 57,500
|
|
|
2020-03-16 |
2020-03-13 |
B
Purchase
|
Grunberg Gregory
Non-Executive Director
|
2,534,854
+inf%
7.89
USD 19,999,998
|
2,534,854
+inf%
|
7.89
|
USD 19,999,998
|
|
|
2020-03-13 |
2020-03-13 |
B
Purchase
|
RA CAPITAL MANAGEMENT, L.P.
Non-Executive Director
Large shareholder
|
6,337,135
+139.7%
7.89
USD 49,999,995
|
6,337,135
+139.7%
|
7.89
|
USD 49,999,995
|
|
|
2020-03-13 |
2020-03-13 |
B
Purchase
|
Shah Rajeev M.
Non-Executive Director
Large shareholder
|
6,337,135
+139.7%
7.89
USD 49,999,995
|
6,337,135
+139.7%
|
7.89
|
USD 49,999,995
|
|
|
2019-06-03 |
2019-05-30 |
B
Purchase
|
Rosen Howard B
|
5,000
+154.3%
5.42
USD 27,100
|
5,000
+154.3%
|
5.42
|
USD 27,100
|
|
|
2018-10-09 |
2018-10-05 |
B
Purchase
|
Grunberg Gregory
Non-Executive Director
|
606,060
+26.7%
8.25
USD 4,999,995
|
606,060
+26.7%
|
8.25
|
USD 4,999,995
|
|
|
2018-10-05 |
2018-10-03 |
B
Purchase
|
Shah Rajeev M.
Non-Executive Director
Large shareholder
|
2,424,242
+114.7%
8.25
USD 19,999,997
|
2,424,242
+114.7%
|
8.25
|
USD 19,999,997
|
|
|
2018-10-05 |
2018-10-03 |
B
Purchase
|
RA CAPITAL MANAGEMENT, LLC
Non-Executive Director
Large shareholder
|
2,424,242
+114.7%
8.25
USD 19,999,997
|
2,424,242
+114.7%
|
8.25
|
USD 19,999,997
|
|
|
2018-02-12 |
2018-02-08 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
25,000
+0.7%
12.93
USD 323,250
|
25,000
+0.7%
|
12.93
|
USD 323,250
|
|
|
2018-02-06 |
2018-02-02 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
37,840
+1.1%
14.73
USD 557,383
|
37,840
+1.1%
|
14.73
|
USD 557,383
|
|
|
2018-02-02 |
2018-02-01 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
22,840
+0.7%
14.99
USD 342,372
|
22,840
+0.7%
|
14.99
|
USD 342,372
|
|
|
2018-02-02 |
2018-01-31 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
339,400
+11.2%
15.00
USD 5,091,000
|
339,400
+11.2%
|
15.00
|
USD 5,091,000
|
|
|
2018-01-30 |
2018-01-29 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
50,000
+1.7%
14.99
USD 749,500
|
50,000
+1.7%
|
14.99
|
USD 749,500
|
|
|
2018-01-30 |
2018-01-26 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
22,760
+0.8%
14.93
USD 339,807
|
22,760
+0.8%
|
14.93
|
USD 339,807
|
|
|
2018-01-24 |
2018-01-24 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
64,637
+2.2%
14.91
USD 963,738
|
64,637
+2.2%
|
14.91
|
USD 963,738
|
|
|
2018-01-24 |
2018-01-23 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
4,363
+0.2%
14.99
USD 65,401
|
4,363
+0.2%
|
14.99
|
USD 65,401
|
|
|
2018-01-24 |
2018-01-22 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
75,000
+2.7%
14.98
USD 1,123,500
|
75,000
+2.7%
|
14.98
|
USD 1,123,500
|
|
