|
2008-07-23 |
2008-07-22 |
B
Purchase
|
Ipsen, S.A.
Large shareholder
|
410,831
+79.1%
8.92
USD 3,664,613
|
410,831
+79.1%
|
8.92
|
USD 3,664,613
|
|
|
2006-10-18 |
2006-10-13 |
B
Purchase
|
Ipsen, S.A.
Large shareholder
|
12,527,245
+inf%
6.17
USD 77,293,102
|
12,527,245
+inf%
|
6.17
|
USD 77,293,102
|
|
|
2006-08-29 |
2006-08-25 |
B
Purchase
|
ROSENFIELD STEPHEN
EVP- Legal Affairs; G.C. & Sec
Officer
|
800
+3.3%
5.06
USD 4,047
|
800
+3.3%
|
5.06
|
USD 4,047
|
|
|
2006-08-29 |
2006-08-25 |
B
Purchase
|
ROSENFIELD STEPHEN
EVP- Legal Affairs; G.C. & Sec
Officer
|
4,200
+21.0%
5.18
USD 21,735
|
4,200
+21.0%
|
5.18
|
USD 21,735
|
|
|
2006-08-29 |
2006-08-25 |
B
Purchase
|
ROSENFIELD STEPHEN
EVP- Legal Affairs; G.C. & Sec
Officer
|
5,000
+33.3%
5.09
USD 25,450
|
5,000
+33.3%
|
5.09
|
USD 25,450
|
|
|
2006-08-29 |
2006-08-25 |
B
Purchase
|
ROSENFIELD STEPHEN
EVP- Legal Affairs; G.C. & Sec
Officer
|
5,000
+50.0%
5.06
USD 25,291
|
5,000
+50.0%
|
5.06
|
USD 25,291
|
|
|
2005-12-14 |
2005-12-14 |
B
Purchase
|
ROSENFIELD STEPHEN
Senior V.P. of Legal Affairs
Officer
|
10,000
+inf%
7.14
USD 71,400
|
10,000
+inf%
|
7.14
|
USD 71,400
|
|
|
2005-12-15 |
2005-12-13 |
B
Purchase
|
BARKAS ALEXANDER E
Non-Executive Director
|
3,000
+7.0%
6.58
USD 19,736
|
3,000
+7.0%
|
6.58
|
USD 19,736
|
|
|
2005-12-15 |
2005-12-13 |
B
Purchase
|
BARKAS ALEXANDER E
Non-Executive Director
|
197,000
+7.0%
6.58
USD 1,295,965
|
197,000
+7.0%
|
6.58
|
USD 1,295,965
|
|
|
2005-12-14 |
2005-12-13 |
B
Purchase
|
RIVERA CHRISTOPHER EUGENE
Snr VP, Commercial Operations
Officer
|
1,000
+inf%
6.59
USD 6,590
|
1,000
+inf%
|
6.59
|
USD 6,590
|
|
|
2005-09-12 |
2005-09-07 |
S
Sale
|
HENNER DENNIS
Non-Executive Director
Large shareholder
|
8,400
-0.1%
12.00
USD 100,800
|
8,400
-0.1%
|
12.00
|
USD 100,800
|
|
|
2005-09-12 |
2005-09-07 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
8,400
-0.1%
12.00
USD 100,800
|
8,400
-0.1%
|
12.00
|
USD 100,800
|
|
|
2005-09-12 |
2005-09-07 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
8,400
-0.1%
12.00
USD 100,800
|
8,400
-0.1%
|
12.00
|
USD 100,800
|
|
|
2005-09-07 |
2005-09-06 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
98,196
-1.4%
12.01
USD 1,179,157
|
98,196
-1.4%
|
12.01
|
USD 1,179,157
|
|
|
2005-09-07 |
2005-09-06 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
98,196
-1.4%
12.01
USD 1,179,157
|
98,196
-1.4%
|
12.01
|
USD 1,179,157
|
|
|
2005-09-07 |
2005-09-06 |
S
Sale
|
HENNER DENNIS
Non-Executive Director
Large shareholder
|
98,196
-1.4%
12.01
USD 1,179,157
|
98,196
-1.4%
|
12.01
|
USD 1,179,157
|
|
|
2005-09-07 |
2005-09-02 |
S
Sale
|
EVNIN LUKE
Large shareholder
|
96,630
-1.4%
12.49
USD 1,206,735
|
96,630
-1.4%
|
12.49
|
USD 1,206,735
|
|
|
2005-09-07 |
2005-09-02 |
S
Sale
|
MPM BIOVENTURES III LLC
Large shareholder
|
96,630
-1.4%
12.49
USD 1,206,735
|
96,630
-1.4%
|
12.49
|
USD 1,206,735
|
|
|
2005-09-07 |
2005-09-02 |
S
Sale
|
HENNER DENNIS
Non-Executive Director
Large shareholder
|
96,630
-1.4%
12.49
USD 1,206,735
|
96,630
-1.4%
|
12.49
|
USD 1,206,735
|
|
|
2005-02-15 |
2005-02-11 |
B
Purchase
|
LESCHLY MARK
Non-Executive Director
Large shareholder
|
325,000
+12.2%
8.00
USD 2,600,000
|
325,000
+12.2%
|
8.00
|
USD 2,600,000
|
|
|
2005-02-11 |
2005-02-11 |
B
Purchase
|
RHO VENTURES IV QP LP
Large shareholder
|
325,000
+12.1%
8.00
USD 2,600,000
|
325,000
+12.1%
|
8.00
|
USD 2,600,000
|
|
|
2005-02-11 |
2005-02-08 |
B
Purchase
|
RHO VENTURES IV QP LP
Large shareholder
|
11,000
+0.4%
8.26
USD 90,860
|
11,000
+0.4%
|
8.26
|
USD 90,860
|
|
|
2005-02-10 |
2005-02-08 |
B
Purchase
|
RHO VENTURES IV QP LP
Large shareholder
|
11,000
+0.4%
8.26
USD 90,860
|
11,000
+0.4%
|
8.26
|
USD 90,860
|
|
|
2004-09-02 |
2004-08-25 |
B
Purchase
|
WHEELER KURT
Large shareholder
|
2,000
+inf%
8.25
USD 16,500
|
2,000
+inf%
|
8.25
|
USD 16,500
|
|
|
2004-03-24 |
2004-03-22 |
B
Purchase
|
PROSPECT VENTURE PARTNERS II LP
Large shareholder
|
8,333
+1.5%
9.00
USD 74,997
|
8,333
+1.5%
|
9.00
|
USD 74,997
|
|
|
2004-03-24 |
2004-03-22 |
B
Purchase
|
PROSPECT VENTURE PARTNERS II LP
Large shareholder
|
547,222
+inf%
9.00
USD 4,924,998
|
547,222
+inf%
|
9.00
|
USD 4,924,998
|
|
|
2004-03-24 |
2004-03-22 |
B
Purchase
|
RHO VENTURES IV QP LP
Large shareholder
|
667,000
+33.4%
9.00
USD 6,003,000
|
667,000
+33.4%
|
9.00
|
USD 6,003,000
|
|
|
2004-03-24 |
2004-03-22 |
B
Purchase
|
BARKAS ALEXANDER E
Non-Executive Director
Large shareholder
|
8,333
+1.5%
9.00
USD 74,997
|
8,333
+1.5%
|
9.00
|
USD 74,997
|
|
|
2004-03-24 |
2004-03-22 |
B
Purchase
|
BARKAS ALEXANDER E
Non-Executive Director
Large shareholder
|
547,222
+inf%
9.00
USD 4,924,998
|
547,222
+inf%
|
9.00
|
USD 4,924,998
|
|
|
2004-03-24 |
2004-03-22 |
B
Purchase
|
LESCHLY MARK
Non-Executive Director
Large shareholder
|
667,000
+33.4%
9.00
USD 6,003,000
|
667,000
+33.4%
|
9.00
|
USD 6,003,000
|
|
|
2004-03-23 |
2004-03-22 |
B
Purchase
|
EVNIN LUKE
Large shareholder
|
670,000
+13408.0%
9.00
USD 6,030,000
|
670,000
+13408.0%
|
9.00
|
USD 6,030,000
|
|
|
2004-03-23 |
2004-03-22 |
B
Purchase
|
HENNER DENNIS
Non-Executive Director
Large shareholder
|
670,000
+13408.0%
9.00
USD 6,030,000
|
670,000
+13408.0%
|
9.00
|
USD 6,030,000
|
|
|
2004-03-23 |
2004-03-22 |
B
Purchase
|
MPM BIOVENTURES III LLC
Large shareholder
|
670,000
+13408.0%
9.00
USD 6,030,000
|
670,000
+13408.0%
|
9.00
|
USD 6,030,000
|
|
