|
2011-11-08 |
2011-11-04 |
PS
Planned sale
|
PATTI JOSEPH M
Chief Scientific Officer
Officer
|
35,000
-100.0%
8.00
USD 280,000
|
35,000
-100.0%
|
8.00
|
USD 280,000
|
|
|
2011-11-02 |
2011-11-01 |
PS
Planned sale
|
MEDFORD RUSSELL M
Non-Executive Director
|
350
-0.9%
4.00
USD 1,400
|
350
-0.9%
|
4.00
|
USD 1,400
|
|
|
2011-09-28 |
2011-09-27 |
S
Sale
|
QVT Associates GP LLC
Large shareholder
|
200,000
-2.5%
3.00
USD 600,000
|
200,000
-2.5%
|
3.00
|
USD 600,000
|
|
|
2011-09-28 |
2011-09-26 |
S
Sale
|
QVT Associates GP LLC
Large shareholder
|
2,500
-0.0%
3.01
USD 7,525
|
2,500
-0.0%
|
3.01
|
USD 7,525
|
|
|
2011-09-28 |
2011-09-26 |
S
Sale
|
QVT Associates GP LLC
Large shareholder
|
1,400
-0.0%
3.10
USD 4,340
|
1,400
-0.0%
|
3.10
|
USD 4,340
|
|
|
2011-09-28 |
2011-09-26 |
S
Sale
|
QVT Associates GP LLC
Large shareholder
|
30,000
-0.4%
2.97
USD 89,100
|
30,000
-0.4%
|
2.97
|
USD 89,100
|
|
|
2011-06-02 |
2011-05-31 |
S
Sale
|
QVT Associates GP LLC
Large shareholder
|
55,000
-0.7%
4.58
USD 251,900
|
55,000
-0.7%
|
4.58
|
USD 251,900
|
|
|
2011-06-02 |
2011-05-31 |
S
Sale
|
QVT Associates GP LLC
Large shareholder
|
600,000
-7.0%
4.49
USD 2,694,000
|
600,000
-7.0%
|
4.49
|
USD 2,694,000
|
|
|
2011-04-11 |
2011-04-11 |
S
Sale
|
QVT Associates GP LLC
Large shareholder
|
78,335
-0.9%
4.29
USD 336,057
|
78,335
-0.9%
|
4.29
|
USD 336,057
|
|
|
2011-04-11 |
2011-04-11 |
S
Sale
|
QVT Associates GP LLC
Large shareholder
|
60,717
-0.7%
4.28
USD 259,869
|
60,717
-0.7%
|
4.28
|
USD 259,869
|
|
|
2011-04-11 |
2011-04-08 |
S
Sale
|
QVT Associates GP LLC
Large shareholder
|
105,382
-1.2%
4.39
USD 462,627
|
105,382
-1.2%
|
4.39
|
USD 462,627
|
|
|
2011-04-11 |
2011-04-08 |
S
Sale
|
QVT Associates GP LLC
Large shareholder
|
230,000
-2.5%
4.37
USD 1,005,100
|
230,000
-2.5%
|
4.37
|
USD 1,005,100
|
|
|
2011-04-11 |
2011-04-07 |
S
Sale
|
QVT Associates GP LLC
Large shareholder
|
129,757
-1.4%
4.52
USD 586,502
|
129,757
-1.4%
|
4.52
|
USD 586,502
|
|
|
2009-12-18 |
2009-12-16 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
43,000
+0.5%
0.85
USD 36,550
|
43,000
+0.5%
|
0.85
|
USD 36,550
|
|
|
2009-12-15 |
2009-12-11 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
25,000
+0.3%
0.72
USD 17,875
|
25,000
+0.3%
|
0.72
|
USD 17,875
|
|
|
2009-12-11 |
2009-12-10 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
75,000
+0.8%
0.73
USD 54,750
|
75,000
+0.8%
|
0.73
|
USD 54,750
|
|
|
2009-12-11 |
2009-12-09 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
23,000
+0.3%
0.89
USD 20,470
|
23,000
+0.3%
|
0.89
|
USD 20,470
|
|
|
2009-12-09 |
2009-12-07 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
27,000
+0.3%
0.92
USD 24,840
|
27,000
+0.3%
|
0.92
|
USD 24,840
|
|
|
2009-12-07 |
2009-12-04 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
21,500
+0.2%
0.96
USD 20,640
|
21,500
+0.2%
|
0.96
|
USD 20,640
|
|
|
2009-12-07 |
2009-12-03 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
25,000
+0.3%
0.99
USD 24,750
|
25,000
+0.3%
|
0.99
|
USD 24,750
|
|
|
2009-12-03 |
2009-12-02 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
14,000
+0.2%
0.98
USD 13,720
|
14,000
+0.2%
|
0.98
|
USD 13,720
|
|
|
2009-12-03 |
2009-12-01 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
51,000
+0.6%
0.98
USD 49,980
|
51,000
+0.6%
|
0.98
|
USD 49,980
|
|
|
2009-12-01 |
2009-11-30 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
50,000
+0.6%
0.99
USD 49,500
|
50,000
+0.6%
|
0.99
|
USD 49,500
|
|
|
2009-12-01 |
2009-11-27 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
12,300
+0.1%
0.96
USD 11,808
|
12,300
+0.1%
|
0.96
|
USD 11,808
|
|
|
2009-12-01 |
2009-11-27 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
2,000
+0.0%
0.96
USD 1,920
|
2,000
+0.0%
|
0.96
|
USD 1,920
|
|
|
2009-11-27 |
2009-11-25 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
300
+0.0%
1.00
USD 300
|
300
+0.0%
|
1.00
|
USD 300
|
|
|
2009-11-27 |
2009-11-24 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
16,292
+0.2%
0.98
USD 15,966
|
16,292
+0.2%
|
0.98
|
USD 15,966
|
|
|
2009-11-24 |
2009-11-23 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
13,000
+0.1%
0.99
USD 12,870
|
13,000
+0.1%
|
0.99
|
USD 12,870
|
|
|
2009-11-24 |
2009-11-20 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
11,700
+0.1%
0.99
USD 11,583
|
11,700
+0.1%
|
0.99
|
USD 11,583
|
|
|
2009-11-24 |
2009-11-19 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
11,000
+0.1%
0.98
USD 10,780
|
11,000
+0.1%
|
0.98
|
USD 10,780
|
|
|
2009-11-19 |
2009-11-18 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
85,000
+1.0%
0.99
USD 84,150
|
85,000
+1.0%
|
0.99
|
USD 84,150
|
|
|
2009-11-19 |
2009-11-17 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
9,500
+0.1%
0.98
USD 9,310
|
9,500
+0.1%
|
0.98
|
USD 9,310
|
|
|
2009-11-13 |
2009-11-12 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
19,000
+0.2%
0.99
USD 18,810
|
19,000
+0.2%
|
0.99
|
USD 18,810
|
|
|
2009-11-13 |
2009-11-11 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
100,000
+1.2%
1.00
USD 100,000
|
100,000
+1.2%
|
1.00
|
USD 100,000
|
|
|
2009-11-12 |
2009-11-10 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
13,000
+0.2%
1.00
USD 13,000
|
13,000
+0.2%
|
1.00
|
USD 13,000
|
|
|
2009-11-12 |
2009-11-09 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
71,000
+0.8%
0.99
USD 70,290
|
71,000
+0.8%
|
0.99
|
USD 70,290
|
|
|
2009-11-09 |
2009-11-06 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
46,000
+0.5%
0.99
USD 45,540
|
46,000
+0.5%
|
0.99
|
USD 45,540
|
|
|
2009-11-09 |
2009-11-05 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
48,000
+0.6%
0.99
USD 47,520
|
48,000
+0.6%
|
0.99
|
USD 47,520
|
|
|
2009-11-05 |
2009-11-04 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
79,000
+1.0%
1.00
USD 79,000
|
79,000
+1.0%
|
1.00
|
USD 79,000
|
|
|
2009-11-05 |
2009-11-03 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
5,000
+0.1%
0.99
USD 4,950
|
5,000
+0.1%
|
0.99
|
USD 4,950
|
|
|
2009-11-05 |
2009-11-03 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
50,000
+0.6%
0.99
USD 49,500
|
50,000
+0.6%
|
0.99
|
USD 49,500
|
|
|
2009-11-03 |
2009-11-02 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
2,600
+0.0%
0.97
USD 2,522
|
2,600
+0.0%
|
0.97
|
USD 2,522
|
|
|
2009-11-03 |
2009-11-02 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
14,880
+0.2%
0.99
USD 14,731
|
14,880
+0.2%
|
0.99
|
USD 14,731
|
|
|
2009-11-03 |
2009-10-30 |
B
Purchase
|
QVT Associates GP LLC
Large shareholder
|
27,556
+0.3%
0.99
USD 27,280
|
27,556
+0.3%
|
0.99
|
USD 27,280
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
PERRY MARK W
Large shareholder
|
1,757,812
+34.2%
1.28
USD 2,249,999
|
1,757,812
+34.2%
|
1.28
|
USD 2,249,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
BARRETT M JAMES
Non-Executive Director
Large shareholder
|
1,757,812
+34.2%
1.28
USD 2,249,999
|
1,757,812
+34.2%
|
1.28
|
USD 2,249,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
BARRIS PETER J
Large shareholder
|
1,757,812
+34.2%
1.28
USD 2,249,999
|
1,757,812
+34.2%
|
1.28
|
USD 2,249,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
SANDELL SCOTT D
Large shareholder
|
1,757,812
+34.2%
1.28
USD 2,249,999
|
1,757,812
+34.2%
|
1.28
|
USD 2,249,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
NEWHALL CHARLES W III
Large shareholder
|
1,757,812
+34.2%
1.28
USD 2,249,999
|
1,757,812
+34.2%
|
1.28
|
USD 2,249,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
TRAINOR III EUGENE A
Large shareholder
|
1,757,812
+34.2%
1.28
USD 2,249,999
|
1,757,812
+34.2%
|
1.28
|
USD 2,249,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
KRAMLICH C RICHARD
Large shareholder
|
1,757,812
+34.2%
1.28
USD 2,249,999
|
1,757,812
+34.2%
|
1.28
|
USD 2,249,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
PERRY MARK W
Large shareholder
|
585,937
+43.2%
1.28
USD 749,999
|
585,937
+43.2%
|
1.28
|
USD 749,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
NEW ENTERPRISE ASSOCIATES 10 L P
Large shareholder
|
1,757,812
+34.2%
1.28
USD 2,249,999
|
1,757,812
+34.2%
|
1.28
|
USD 2,249,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
BARRETT M JAMES
Non-Executive Director
Large shareholder
|
585,937
+43.2%
1.28
USD 749,999
|
585,937
+43.2%
|
1.28
|
USD 749,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
BARRIS PETER J
Large shareholder
|
585,937
+43.2%
1.28
USD 749,999
|
585,937
+43.2%
|
1.28
|
USD 749,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
SANDELL SCOTT D
Large shareholder
|
585,937
+43.2%
1.28
USD 749,999
|
585,937
+43.2%
|
1.28
|
USD 749,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
NEWHALL CHARLES W III
Large shareholder
|
585,937
+43.2%
1.28
USD 749,999
|
585,937
+43.2%
|
1.28
|
USD 749,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
TRAINOR III EUGENE A
Large shareholder
|
585,937
+43.2%
1.28
USD 749,999
|
585,937
+43.2%
|
1.28
|
USD 749,999
|
|
|
2009-10-30 |
2009-10-28 |
B
Purchase
|
KRAMLICH C RICHARD
Large shareholder
|
585,937
+43.2%
1.28
USD 749,999
|
585,937
+43.2%
|
1.28
|
USD 749,999
|
|
|
2008-12-04 |
2008-12-03 |
B
Purchase
|
Henson Geoffrey W.
Vice President
Officer
|
140,000
+954.6%
0.25
USD 35,000
|
140,000
+954.6%
|
0.25
|
USD 35,000
|
|
|
2008-12-03 |
2008-12-02 |
B
Purchase
|
PLUMB RUSSELL H
CEO, Chief Executive Officer
Executive Director
|
7,400
+3.5%
0.24
USD 1,805
|
7,400
+3.5%
|
0.24
|
USD 1,805
|
|
|
2008-12-01 |
2008-11-25 |
B
Purchase
|
PLUMB RUSSELL H
CEO, Chief Executive Officer
Executive Director
|
5,600
+2.7%
0.25
USD 1,387
|
5,600
+2.7%
|
0.25
|
USD 1,387
|
|
|
2008-11-21 |
2008-11-20 |
B
Purchase
|
PLUMB RUSSELL H
CEO, Chief Executive Officer
Executive Director
|
16,600
+8.8%
0.21
USD 3,536
|
16,600
+8.8%
|
0.21
|
USD 3,536
|
|
|
2008-11-17 |
2008-11-14 |
B
Purchase
|
PATTI JOSEPH M
Chief Scientific Officer
Officer
|
20,000
+16.8%
0.22
USD 4,400
|
20,000
+16.8%
|
0.22
|
USD 4,400
|
|
|
2006-05-11 |
2006-05-11 |
B
Purchase
|
Willard A Keith
Non-Executive Director
|
2,500
+inf%
1.99
USD 4,975
|
2,500
+inf%
|
1.99
|
USD 4,975
|
|
|
2006-01-18 |
2006-01-13 |
PS
Planned sale
|
PATTI JOSEPH M
Chief Scientific Officer
Executive Director
|
35,000
-50.3%
9.04
USD 316,425
|
35,000
-50.3%
|
9.04
|
USD 316,425
|
|
|
2006-01-13 |
2006-01-12 |
PS
Planned sale
|
PATTI JOSEPH M
Chief Scientific Officer
Executive Director
|
30,000
-30.1%
9.05
USD 271,401
|
30,000
-30.1%
|
9.05
|
USD 271,401
|
|
|
2006-01-13 |
2006-01-11 |
PS
Planned sale
|
PATTI JOSEPH M
Chief Scientific Officer
Executive Director
|
12,350
-11.0%
9.01
USD 111,271
|
12,350
-11.0%
|
9.01
|
USD 111,271
|
|
|
2006-01-11 |
2006-01-10 |
PS
Planned sale
|
PATTI JOSEPH M
Chief Scientific Officer
Executive Director
|
27,650
-19.8%
9.00
USD 248,850
|
27,650
-19.8%
|
9.00
|
USD 248,850
|
|
|
2006-01-11 |
2006-01-10 |
PS
Planned sale
|
HETHERINGTON SETH V
VP, Clinical Development & CMO
Officer
|
8,305
-100.0%
9.00
USD 74,745
|
8,305
-100.0%
|
9.00
|
USD 74,745
|
|
|
2006-01-11 |
2006-01-10 |
PS
Planned sale
|
PLUMB RUSSELL H
CFO, VP of Admin. & Finance
Officer
|
20,000
-50.8%
9.00
USD 180,000
|
20,000
-50.8%
|
9.00
|
USD 180,000
|
|
|
2006-01-06 |
2006-01-05 |
PS
Planned sale
|
JOHNSTON WILLIAM D
President & CEO
Executive Director
|
2,200
-3.2%
8.47
USD 18,633
|
2,200
-3.2%
|
8.47
|
USD 18,633
|
|
|
2006-01-05 |
2006-01-04 |
PS
Planned sale
|
JOHNSTON WILLIAM D
President & CEO
Executive Director
|
15,900
-18.8%
8.46
USD 134,508
|
15,900
-18.8%
|
8.46
|
USD 134,508
|
|
|
2006-01-04 |
2006-01-03 |
PS
Planned sale
|
JOHNSTON WILLIAM D
President & CEO
Executive Director
|
16,200
-1.9%
8.41
USD 136,227
|
16,200
-1.9%
|
8.41
|
USD 136,227
|
|
|
2004-11-12 |
2004-11-10 |
B
Purchase
|
ALSOP STEWART II
Large shareholder
|
1,937,970
+42.5%
7.34
USD 14,224,700
|
1,937,970
+42.5%
|
7.34
|
USD 14,224,700
|
|
