|
2020-05-01 |
2020-05-01 |
B
Purchase
|
Avoro Capital Advisors LLC
Non-Executive Director
Large shareholder
|
1,750,000
+7.1%
28.50
USD 49,875,000
|
1,750,000
+7.1%
|
28.50
|
USD 49,875,000
|
|
|
2019-12-09 |
2019-12-05 |
B
Purchase
|
Avoro Capital Advisors LLC
Non-Executive Director
Large shareholder
|
2,000,000
+8.9%
17.50
USD 35,000,000
|
2,000,000
+8.9%
|
17.50
|
USD 35,000,000
|
|
|
2019-10-04 |
2019-10-03 |
B
Purchase
|
Avoro Capital Advisors LLC
Large shareholder
|
500,000
+2.3%
14.10
USD 7,050,000
|
500,000
+2.3%
|
14.10
|
USD 7,050,000
|
|
|
2019-10-03 |
2019-10-03 |
B
Purchase
|
BALL BRYAN
Chief Quality Officer
|
5,000
+100.0%
14.18
USD 70,897
|
5,000
+100.0%
|
14.18
|
USD 70,897
|
|
|
2019-10-04 |
2019-10-02 |
B
Purchase
|
Avoro Capital Advisors LLC
Large shareholder
|
1,000,000
+4.8%
13.23
USD 13,230,000
|
1,000,000
+4.8%
|
13.23
|
USD 13,230,000
|
|
|
2019-06-28 |
2019-06-28 |
B
Purchase
|
Avoro Capital Advisors LLC
Large shareholder
|
250,000
+1.2%
13.84
USD 3,460,000
|
250,000
+1.2%
|
13.84
|
USD 3,460,000
|
|
|
2019-06-28 |
2019-06-27 |
B
Purchase
|
Avoro Capital Advisors LLC
Large shareholder
|
350,000
+1.7%
13.68
USD 4,788,000
|
350,000
+1.7%
|
13.68
|
USD 4,788,000
|
|
|
2019-06-28 |
2019-06-26 |
B
Purchase
|
Avoro Capital Advisors LLC
Large shareholder
|
400,000
+2.0%
13.25
USD 5,300,000
|
400,000
+2.0%
|
13.25
|
USD 5,300,000
|
|
|
2019-06-21 |
2019-06-20 |
B
Purchase
|
BALL BRYAN
Chief Quality Officer
|
5,000
+inf%
13.35
USD 66,750
|
5,000
+inf%
|
13.35
|
USD 66,750
|
|
|
2019-06-05 |
2019-06-05 |
B
Purchase
|
Avoro Capital Advisors LLC
Large shareholder
|
250,000
+1.3%
12.47
USD 3,117,500
|
250,000
+1.3%
|
12.47
|
USD 3,117,500
|
|
|
2019-06-05 |
2019-06-04 |
B
Purchase
|
Avoro Capital Advisors LLC
Large shareholder
|
500,000
+2.6%
12.10
USD 6,050,000
|
500,000
+2.6%
|
12.10
|
USD 6,050,000
|
|
|
2019-06-05 |
2019-06-03 |
B
Purchase
|
Avoro Capital Advisors LLC
Large shareholder
|
785,539
+4.3%
12.19
USD 9,575,720
|
785,539
+4.3%
|
12.19
|
USD 9,575,720
|
|
|
2019-05-15 |
2019-05-15 |
B
Purchase
|
Avoro Capital Advisors LLC
|
125,000
+0.7%
14.95
USD 1,868,750
|
125,000
+0.7%
|
14.95
|
USD 1,868,750
|
|
|
2019-05-15 |
2019-05-14 |
B
Purchase
|
Avoro Capital Advisors LLC
|
125,000
+0.7%
15.40
USD 1,925,000
|
125,000
+0.7%
|
15.40
|
USD 1,925,000
|
|
|
2019-05-15 |
2019-05-13 |
B
Purchase
|
Avoro Capital Advisors LLC
|
500,000
+2.8%
15.07
USD 7,535,000
|
500,000
+2.8%
|
15.07
|
USD 7,535,000
|
|
|
2018-06-19 |
2018-06-15 |
B
Purchase
|
venBio Select Advisor LLC
Non-Executive Director
Large shareholder
|
200,000
+1.1%
23.39
USD 4,678,000
|
200,000
+1.1%
|
23.39
|
USD 4,678,000
|
|
|
2018-06-15 |
2018-06-15 |
B
Purchase
|
venBio Select Advisor LLC
Non-Executive Director
Large shareholder
|
575,000
+3.4%
24.00
USD 13,800,000
|
575,000
+3.4%
|
24.00
|
USD 13,800,000
|
|
|
2018-03-12 |
2018-03-07 |
S
Sale
|
GOLDENBERG DAVID M
|
20,000
-0.4%
17.75
USD 355,000
|
20,000
-0.4%
|
17.75
|
USD 355,000
|
|
|
2018-03-12 |
2018-03-07 |
S
Sale
|
GOLDENBERG DAVID M
|
20,000
-0.4%
17.60
USD 352,000
|
20,000
-0.4%
|
17.60
|
USD 352,000
|
|
|
2018-03-12 |
2018-03-07 |
S
Sale
|
GOLDENBERG DAVID M
|
20,000
-1.1%
17.50
USD 350,000
|
20,000
-1.1%
|
17.50
|
USD 350,000
|
|
|
2018-03-12 |
2018-03-05 |
S
Sale
|
GOLDENBERG DAVID M
|
20,000
-0.4%
17.17
USD 343,400
|
20,000
-0.4%
|
17.17
|
USD 343,400
|
|
|
2018-03-12 |
2018-03-05 |
S
Sale
|
GOLDENBERG DAVID M
|
20,000
-0.4%
17.30
USD 346,000
|
20,000
-0.4%
|
17.30
|
USD 346,000
|
|
|
2018-03-12 |
2018-02-28 |
S
Sale
|
GOLDENBERG DAVID M
|
17,729
-0.3%
17.09
USD 302,989
|
17,729
-0.3%
|
17.09
|
USD 302,989
|
|
|
2017-11-21 |
2017-11-20 |
S
Sale
|
MARKISON BRIAN A
|
8,390
-8.5%
11.89
USD 99,724
|
8,390
-8.5%
|
11.89
|
USD 99,724
|
|
|
2017-11-16 |
2017-11-15 |
B
Purchase
|
venBio Select Advisor LLC
Large shareholder
|
175,000
+1.1%
10.97
USD 1,919,750
|
175,000
+1.1%
|
10.97
|
USD 1,919,750
|
|
|
2017-11-15 |
2017-11-15 |
B
Purchase
|
Aghazadeh Behzad
Large shareholder
|
175,000
+1.1%
10.97
USD 1,919,750
|
175,000
+1.1%
|
10.97
|
USD 1,919,750
|
|
|
2017-11-16 |
2017-11-14 |
B
Purchase
|
venBio Select Advisor LLC
Large shareholder
|
1,150,000
+7.8%
10.39
USD 11,948,500
|
1,150,000
+7.8%
|
10.39
|
USD 11,948,500
|
|
|
2017-11-15 |
2017-11-14 |
B
Purchase
|
Aghazadeh Behzad
Large shareholder
|
1,150,000
+7.8%
10.39
USD 11,948,500
|
1,150,000
+7.8%
|
10.39
|
USD 11,948,500
|
|
|
2017-09-05 |
2017-09-01 |
S
Sale
|
GOLDENBERG CYNTHIA L
|
10,000
-1.3%
12.90
USD 129,000
|
10,000
-1.3%
|
12.90
|
USD 129,000
|
|
|
2017-09-05 |
2017-09-01 |
S
Sale
|
GOLDENBERG DAVID M
See Remarks
Executive Director
|
10,000
-0.3%
12.90
USD 129,000
|
10,000
-0.3%
|
12.90
|
USD 129,000
|
|
|
2017-09-05 |
2017-08-31 |
S
Sale
|
GOLDENBERG CYNTHIA L
|
5,000
-0.6%
12.50
USD 62,500
|
5,000
-0.6%
|
12.50
|
USD 62,500
|
|
|
2017-09-05 |
2017-08-31 |
S
Sale
|
GOLDENBERG CYNTHIA L
|
5,000
-0.6%
12.25
USD 61,250
|
5,000
-0.6%
|
12.25
|
USD 61,250
|
|
|
2017-09-05 |
2017-08-31 |
S
Sale
|
GOLDENBERG DAVID M
See Remarks
Executive Director
|
5,000
-0.1%
12.50
USD 62,500
|
5,000
-0.1%
|
12.50
|
USD 62,500
|
|
|
2017-09-05 |
2017-08-31 |
S
Sale
|
GOLDENBERG DAVID M
See Remarks
Executive Director
|
5,000
-0.1%
12.25
USD 61,250
|
5,000
-0.1%
|
12.25
|
USD 61,250
|
|
|
2017-08-28 |
2017-08-28 |
S
Sale
|
GOLDENBERG DAVID M
See Remarks
Executive Director
|
10,000
-0.3%
11.56
USD 115,591
|
10,000
-0.3%
|
11.56
|
USD 115,591
|
|
|
2017-08-28 |
2017-08-28 |
S
Sale
|
GOLDENBERG DAVID M
See Remarks
Executive Director
|
5,000
11.45
USD 57,250
|
5,000
|
11.45
|
USD 57,250
|
|
|
2017-08-28 |
2017-08-28 |
S
Sale
|
GOLDENBERG CYNTHIA L
|
10,000
-1.2%
11.56
USD 115,591
|
10,000
-1.2%
|
11.56
|
USD 115,591
|
|
|
2017-08-28 |
2017-08-28 |
S
Sale
|
GOLDENBERG CYNTHIA L
|
5,000
-0.6%
11.45
USD 57,250
|
5,000
-0.6%
|
11.45
|
USD 57,250
|
|
|
2017-08-28 |
2017-08-24 |
S
Sale
|
GOLDENBERG DAVID M
See Remarks
Executive Director
|
25,000
10.24
USD 256,105
|
25,000
|
10.24
|
USD 256,105
|
|
|
2017-08-28 |
2017-08-24 |
S
Sale
|
GOLDENBERG CYNTHIA L
|
25,000
-3.0%
10.24
USD 256,105
|
25,000
-3.0%
|
10.24
|
USD 256,105
|
|
|
2017-08-23 |
2017-08-23 |
S
Sale
|
GOLDENBERG DAVID M
See Remarks
Executive Director
|
10,000
-0.3%
9.50
USD 95,000
|
10,000
-0.3%
|
9.50
|
USD 95,000
|
|
|
2017-08-23 |
2017-08-23 |
S
Sale
|
GOLDENBERG CYNTHIA L
|
10,000
-1.2%
9.50
USD 95,000
|
10,000
-1.2%
|
9.50
|
USD 95,000
|
|
|
2017-08-23 |
2017-08-22 |
S
Sale
|
GOLDENBERG DAVID M
See Remarks
Executive Director
|
10,000
-0.3%
9.50
USD 95,000
|
10,000
-0.3%
|
9.50
|
USD 95,000
|
|
|
2017-08-23 |
2017-08-22 |
S
Sale
|
GOLDENBERG CYNTHIA L
|
10,000
-1.2%
9.50
USD 95,000
|
10,000
-1.2%
|
9.50
|
USD 95,000
|
|
|
2017-08-23 |
2017-08-21 |
S
Sale
|
GOLDENBERG DAVID M
See Remarks
Executive Director
|
20,000
-0.6%
8.97
USD 179,426
|
20,000
-0.6%
|
8.97
|
USD 179,426
|
|
|
2017-08-23 |
2017-08-21 |
S
Sale
|
GOLDENBERG CYNTHIA L
|
20,000
-2.3%
8.97
USD 179,426
|
20,000
-2.3%
|
8.97
|
USD 179,426
|
|
|
2016-08-25 |
2016-08-24 |
S
Sale
|
Stark Don C
Non-Executive Director
|
9,900
-15.1%
2.97
USD 29,451
|
9,900
-15.1%
|
2.97
|
USD 29,451
|
|
|
2016-08-25 |
2016-08-23 |
S
Sale
|
PAETZOLD MARY E
Non-Executive Director
|
15,000
-18.2%
2.98
USD 44,673
|
15,000
-18.2%
|
2.98
|
USD 44,673
|
|
|
2016-08-25 |
2016-08-23 |
S
Sale
|
MARKISON BRIAN A
Non-Executive Director
|
15,000
-16.6%
2.98
USD 44,634
|
15,000
-16.6%
|
2.98
|
USD 44,634
|
|
|
2016-06-14 |
2016-06-13 |
S
Sale
|
GOLDENBERG DAVID M
CSO & Chairman of the BOD
Executive Director
|
128,674
-3.7%
3.02
USD 389,200
|
128,674
-3.7%
|
3.02
|
USD 389,200
|
|
|
2016-06-14 |
2016-06-13 |
S
Sale
|
GOLDENBERG DAVID M
CSO & Chairman of the BOD
Executive Director
|
139,950
-5.3%
3.02
USD 422,621
|
139,950
-5.3%
|
3.02
|
USD 422,621
|
|
|
2016-06-14 |
2016-06-13 |
S
Sale
|
GOLDENBERG CYNTHIA L
President and CEO
Executive Director
|
139,950
-2.6%
3.02
USD 422,621
|
139,950
-2.6%
|
3.02
|
USD 422,621
|
|
|
2016-06-14 |
2016-06-13 |
S
Sale
|
GOLDENBERG CYNTHIA L
President and CEO
Executive Director
|
128,674
-16.8%
3.02
USD 389,200
|
128,674
-16.8%
|
3.02
|
USD 389,200
|
|
|
2016-06-14 |
2016-06-10 |
S
Sale
|
GOLDENBERG DAVID M
CSO & Chairman of the BOD
Executive Director
|
11,326
-0.3%
3.07
USD 34,781
|
11,326
-0.3%
|
3.07
|
USD 34,781
|
|
|
2016-06-14 |
2016-06-10 |
S
Sale
|
GOLDENBERG DAVID M
CSO & Chairman of the BOD
Executive Director
|
92,040
-3.6%
3.05
USD 281,155
|
92,040
-3.6%
|
3.05
|
USD 281,155
|
|
|
2016-06-14 |
2016-06-10 |
S
Sale
|
GOLDENBERG CYNTHIA L
President and CEO
Executive Director
|
92,040
-1.7%
3.05
USD 281,155
|
92,040
-1.7%
|
3.05
|
USD 281,155
|
|
|
2016-06-14 |
2016-06-10 |
S
Sale
|
GOLDENBERG CYNTHIA L
President and CEO
Executive Director
|
11,326
-1.7%
3.07
USD 34,781
|
11,326
-1.7%
|
3.07
|
USD 34,781
|
|
|
2016-06-08 |
2016-06-08 |
S
Sale
|
GOLDENBERG DAVID M
CSO & Chairman of the BOD
Executive Director
|
41,441
-1.2%
3.62
USD 150,219
|
41,441
-1.2%
|
3.62
|
USD 150,219
|
|
|
2016-06-08 |
2016-06-08 |
S
Sale
|
GOLDENBERG DAVID M
CSO & Chairman of the BOD
Executive Director
|
120,388
-4.6%
3.64
USD 438,778
|
120,388
-4.6%
|
3.64
|
USD 438,778
|
|
|
2016-06-08 |
2016-06-08 |
S
Sale
|
GOLDENBERG CYNTHIA L
President and CEO
Executive Director
|
120,388
-2.2%
3.64
USD 438,778
|
120,388
-2.2%
|
3.64
|
USD 438,778
|
|
|
2016-06-08 |
2016-06-08 |
S
Sale
|
GOLDENBERG CYNTHIA L
President and CEO
Executive Director
|
41,441
-6.1%
3.62
USD 150,219
|
41,441
-6.1%
|
3.62
|
USD 150,219
|
|
|
2016-06-08 |
2016-06-07 |
S
Sale
|
GOLDENBERG DAVID M
CSO & Chairman of the BOD
Executive Director
|
4,600
-0.1%
4.01
USD 18,427
|
4,600
-0.1%
|
4.01
|
USD 18,427
|
|
|
2016-06-08 |
2016-06-07 |
S
Sale
|
GOLDENBERG DAVID M
CSO & Chairman of the BOD
Executive Director
|
12,300
-0.5%
3.98
USD 48,954
|
12,300
-0.5%
|
3.98
|
USD 48,954
|
|
|
2016-06-08 |
2016-06-07 |
S
Sale
|
GOLDENBERG CYNTHIA L
President and CEO
Executive Director
|
12,300
-0.2%
3.98
USD 48,954
|
12,300
-0.2%
|
3.98
|
USD 48,954
|
|
|
2016-06-08 |
2016-06-07 |
S
Sale
|
GOLDENBERG CYNTHIA L
President and CEO
Executive Director
|
4,600
-0.7%
4.01
USD 18,427
|
4,600
-0.7%
|
4.01
|
USD 18,427
|
|
|
2016-06-08 |
2016-06-06 |
S
Sale
|
GOLDENBERG DAVID M
CSO & Chairman of the BOD
Executive Director
|
63,959
-1.9%
4.09
USD 261,880
|
63,959
-1.9%
|
4.09
|
USD 261,880
|
|
|
2016-06-08 |
2016-06-06 |
S
Sale
|
GOLDENBERG DAVID M
CSO & Chairman of the BOD
Executive Director
|
110,322
-4.2%
4.09
USD 451,007
|
110,322
-4.2%
|
4.09
|
USD 451,007
|
|
|
2016-06-08 |
2016-06-06 |
S
Sale
|
GOLDENBERG CYNTHIA L
President and CEO
Executive Director
|
110,322
-2.1%
4.09
USD 451,007
|
110,322
-2.1%
|
4.09
|
USD 451,007
|
|
|
2016-06-08 |
2016-06-06 |
S
Sale
|
GOLDENBERG CYNTHIA L
President and CEO
Executive Director
|
63,959
-9.1%
4.09
USD 261,880
|
63,959
-9.1%
|
4.09
|
USD 261,880
|
|
|
2015-12-04 |
2015-12-01 |
S
Sale
|
Stark Don C
Non-Executive Director
|
5,100
-10.1%
3.16
USD 16,091
|
5,100
-10.1%
|
3.16
|
USD 16,091
|
|
|
2015-06-16 |
2015-06-15 |
S
Sale
|
GOLDENBERG CYNTHIA L
President and CEO
Executive Director
|
90,666
-1.7%
4.07
USD 368,920
|
90,666
-1.7%
|
4.07
|
USD 368,920
|
|
|
2015-06-16 |
2015-06-15 |
S
Sale
|
GOLDENBERG CYNTHIA L
President and CEO
Executive Director
|
82,077
-1.5%
4.07
USD 333,971
|
82,077
-1.5%
|
4.07
|
USD 333,971
|
|
|
2015-06-16 |
2015-06-15 |
S
Sale
|
GOLDENBERG CYNTHIA L
President and CEO
Executive Director
|
38,248
-6.6%
4.12
USD 157,677
|
38,248
-6.6%
|
4.12
|
USD 157,677
|
|
|
2015-06-16 |
2015-06-15 |
S
Sale
|
GOLDENBERG DAVID M
CSO & Chairman of the BOD
Executive Director
|
38,248
-1.2%
4.12
USD 157,677
|
38,248
-1.2%
|
4.12
|
USD 157,677
|
|
|
2015-06-16 |
2015-06-15 |
S
Sale
|
GOLDENBERG DAVID M
CSO & Chairman of the BOD
Executive Director
|
90,666
-3.3%
4.07
USD 368,920
|
90,666
-3.3%
|
4.07
|
USD 368,920
|
|
