|
2025-04-04 |
2025-04-03 |
B
Purchase
|
Thompson Peter A.
Non-Executive Director
Large shareholder
|
1,000
+38.9%
20.13
USD 2,500,005
|
1,000
+38.9%
|
20.13
|
USD 100,000
|
|
|
2025-04-04 |
2025-04-03 |
B
Purchase
|
Thompson Peter A.
Non-Executive Director
Large shareholder
|
1,000
+2.6%
20.13
USD 7,499,995
|
1,000
+2.6%
|
20.13
|
USD 100,000
|
|
|
2025-04-04 |
2025-04-03 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
1,000
+38.9%
20.13
USD 2,500,005
|
1,000
+38.9%
|
20.13
|
USD 100,000
|
|
|
2025-04-04 |
2025-04-03 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
1,000
+2.6%
20.13
USD 7,499,995
|
1,000
+2.6%
|
20.13
|
USD 100,000
|
|
|
2025-03-11 |
2025-03-07 |
PS
Planned sale
|
Russell Alan J
Chief Scientific Officer
Executive Director
|
200
-1.3%
30.02
USD 6,004
|
200
-1.3%
|
30.02
|
USD 6,004
|
|
|
2025-03-11 |
2025-03-07 |
PS
Planned sale
|
KOCH KEVIN
President and CEO
Executive Director
|
100
-0.7%
30.00
USD 3,000
|
100
-0.7%
|
30.00
|
USD 3,000
|
|
|
2025-02-07 |
2025-02-06 |
PS
Planned sale
|
Russell Alan J
Chief Scientific Officer
Executive Director
|
1,200
-7.5%
30.13
USD 36,153
|
1,200
-7.5%
|
30.13
|
USD 36,153
|
|
|
2025-02-07 |
2025-02-06 |
PS
Planned sale
|
KOCH KEVIN
President and CEO
Executive Director
|
900
-5.9%
31.13
USD 28,018
|
900
-5.9%
|
31.13
|
USD 28,018
|
|
|
2025-02-07 |
2025-02-05 |
PS
Planned sale
|
Russell Alan J
Chief Scientific Officer
Executive Director
|
8,015
-35.0%
30.02
USD 240,623
|
8,015
-35.0%
|
30.02
|
USD 240,623
|
|
|
2025-02-07 |
2025-02-05 |
PS
Planned sale
|
Derakhshan Behrad
Chief Business Officer
Officer
|
10,000
-37.3%
30.03
USD 300,300
|
10,000
-37.3%
|
30.03
|
USD 300,300
|
|
|
2025-02-07 |
2025-02-05 |
PS
Planned sale
|
KOCH KEVIN
President and CEO
Executive Director
|
8,636
-37.4%
30.03
USD 259,298
|
8,636
-37.4%
|
30.03
|
USD 259,298
|
|
|
2025-01-30 |
2025-01-28 |
S
Sale
|
Donovan Joanne M.
CMO
Officer
|
25,000
-60.4%
27.63
USD 690,658
|
25,000
-60.4%
|
27.63
|
USD 690,658
|
|
|
2024-12-31 |
2024-12-30 |
S
Sale
|
Russell Alan J
Chief Scientific Officer
Executive Director
|
100,000
-87.1%
27.37
USD 2,737,470
|
100,000
-87.1%
|
27.37
|
USD 2,737,470
|
|
|
2024-12-27 |
2024-12-24 |
S
Sale
|
Semigran Marc
Chief Development Officer
Officer
|
1,729
-20.5%
30.08
USD 52,009
|
1,729
-20.5%
|
30.08
|
USD 52,009
|
|
|
2024-12-27 |
2024-12-24 |
PS
Planned sale
|
Semigran Marc
Chief Development Officer
Officer
|
27,980
-76.8%
29.66
USD 829,906
|
27,980
-76.8%
|
29.66
|
USD 829,906
|
|
|
2024-09-24 |
2024-09-23 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
20,922
-86.5%
27.63
USD 578,064
|
20,922
-86.5%
|
27.63
|
USD 578,064
|
|
|
2024-09-24 |
2024-09-20 |
S
Sale
|
Derakhshan Behrad
Chief Business Officer
Officer
|
42,068
-73.6%
29.03
USD 1,221,133
|
42,068
-73.6%
|
29.03
|
USD 1,221,133
|
|
|
2024-09-24 |
2024-09-20 |
S
Sale
|
Russell Alan J
Chief Scientific Officer
Executive Director
|
815
-6.0%
29.51
USD 24,049
|
815
-6.0%
|
29.51
|
USD 24,049
|
|
|
2024-09-24 |
2024-09-20 |
S
Sale
|
Russell Alan J
Chief Scientific Officer
Executive Director
|
74,185
-84.6%
28.25
USD 2,096,053
|
74,185
-84.6%
|
28.25
|
USD 2,096,053
|
|
|
2024-09-24 |
2024-09-20 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
50,000
-93.9%
28.37
USD 1,418,510
|
50,000
-93.9%
|
28.37
|
USD 1,418,510
|
|
|
2024-09-24 |
2024-09-20 |
PS
Planned sale
|
Donovan Joanne M.
CMO
Officer
|
7,162
-33.0%
28.29
USD 202,603
|
7,162
-33.0%
|
28.29
|
USD 202,603
|
|
|
2024-09-24 |
2024-09-20 |
S
Sale
|
Carruthers R Michael
Chief Financial Officer
Officer
|
50,000
-87.9%
28.55
USD 1,427,385
|
50,000
-87.9%
|
28.55
|
USD 1,427,385
|
|
|
2024-09-24 |
2024-09-20 |
S
Sale
|
Carruthers R Michael
Chief Financial Officer
Officer
|
24,960
-78.3%
28.59
USD 713,512
|
24,960
-78.3%
|
28.59
|
USD 713,512
|
|
|
2024-09-24 |
2024-09-20 |
S
Sale
|
Carruthers R Michael
Chief Financial Officer
Officer
|
4,064
-11.3%
28.59
USD 116,174
|
4,064
-11.3%
|
28.59
|
USD 116,174
|
|
|
2024-09-24 |
2024-09-20 |
S
Sale
|
Carruthers R Michael
Chief Financial Officer
Officer
|
46,068
-56.2%
28.59
USD 1,316,909
|
46,068
-56.2%
|
28.59
|
USD 1,316,909
|
|
|
2024-05-03 |
2024-05-02 |
S
Sale
|
Carruthers R Michael
Chief Financial Officer
Officer
|
2,157
-5.8%
18.91
USD 40,789
|
2,157
-5.8%
|
18.91
|
USD 40,789
|
|
|
2024-05-03 |
2024-05-02 |
S
Sale
|
Donovan Joanne M.
CMO
Officer
|
3,682
-15.6%
18.91
USD 69,627
|
3,682
-15.6%
|
18.91
|
USD 69,627
|
|
|
2024-05-03 |
2024-05-02 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
1,956
-37.6%
18.91
USD 36,988
|
1,956
-37.6%
|
18.91
|
USD 36,988
|
|
|
2024-05-03 |
2024-05-02 |
S
Sale
|
Russell Alan J
Chief Scientific Officer
Executive Director
|
1,576
-17.9%
18.91
USD 29,802
|
1,576
-17.9%
|
18.91
|
USD 29,802
|
|
|
2024-05-03 |
2024-05-02 |
S
Sale
|
KOCH KEVIN
President and CEO
Executive Director
|
3,152
-17.9%
18.91
USD 59,604
|
3,152
-17.9%
|
18.91
|
USD 59,604
|
|
|
2024-05-03 |
2024-05-02 |
S
Sale
|
Derakhshan Behrad
Chief Business Officer
Officer
|
1,718
-11.3%
18.91
USD 32,487
|
1,718
-11.3%
|
18.91
|
USD 32,487
|
|
|
2024-02-09 |
2024-02-09 |
S
Sale
|
Derakhshan Behrad
Chief Business Officer
Officer
|
4,800
-40.6%
20.04
USD 96,209
|
4,800
-40.6%
|
20.04
|
USD 96,209
|
|
|
2024-02-09 |
2024-02-09 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
8,029
-100.0%
20.01
USD 160,657
|
8,029
-100.0%
|
20.01
|
USD 160,657
|
|
|
2024-02-09 |
2024-02-08 |
S
Sale
|
Derakhshan Behrad
Chief Business Officer
Officer
|
4,600
-39.6%
20.01
USD 92,049
|
4,600
-39.6%
|
20.01
|
USD 92,049
|
|
|
2024-02-09 |
2024-02-08 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
3,813
-100.0%
20.01
USD 76,285
|
3,813
-100.0%
|
20.01
|
USD 76,285
|
|
|
2024-02-09 |
2024-02-07 |
S
Sale
|
Derakhshan Behrad
Chief Business Officer
Officer
|
600
-7.9%
20.00
USD 12,000
|
600
-7.9%
|
20.00
|
USD 12,000
|
|
|
2024-02-09 |
2024-02-07 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
17,993
-100.0%
20.00
USD 359,864
|
17,993
-100.0%
|
20.00
|
USD 359,864
|
|
|
2024-01-25 |
2024-01-23 |
B
Purchase
|
Thompson Peter A.
Non-Executive Director
Large shareholder
|
454,545
+3.3%
11.00
USD 4,999,995
|
454,545
+3.3%
|
11.00
|
USD 4,999,995
|
|
|
2024-01-25 |
2024-01-23 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
454,545
+3.3%
11.00
USD 4,999,995
|
454,545
+3.3%
|
11.00
|
USD 4,999,995
|
|
|
2024-01-25 |
2024-01-23 |
S
Sale
|
Carruthers R Michael
Chief Financial Officer
Officer
|
90,000
-75.6%
15.78
USD 1,419,759
|
90,000
-75.6%
|
15.78
|
USD 1,419,759
|
|
|
2023-12-28 |
2023-12-27 |
PS
Planned sale
|
MOORE JOHN R
General Counsel
Officer
|
8,497
-100.0%
10.50
USD 89,219
|
8,497
-100.0%
|
10.50
|
USD 89,219
|
|
|
2023-12-28 |
2023-12-26 |
B
Purchase
|
Fox Jonathan C
Non-Executive Director
|
10,857
+inf%
9.30
USD 100,958
|
10,857
+inf%
|
9.30
|
USD 100,958
|
|
|
2023-12-28 |
2023-12-26 |
S
Sale
|
Russell Alan J
Chief Scientific Officer
Executive Director
|
172,585
-98.0%
9.33
USD 1,610,097
|
172,585
-98.0%
|
9.33
|
USD 1,610,097
|
|
|
2023-05-03 |
2023-05-02 |
S
Sale
|
Donovan Joanne M.
CMO
Officer
|
3,254
-24.6%
8.90
USD 28,977
|
3,254
-24.6%
|
8.90
|
USD 28,977
|
|
|
2023-05-03 |
2023-05-02 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
1,897
-22.4%
8.90
USD 16,893
|
1,897
-22.4%
|
8.90
|
USD 16,893
|
|
|
2023-05-03 |
2023-05-02 |
S
Sale
|
Russell Alan J
Chief Scientific Officer
Executive Director
|
1,602
-0.9%
8.90
USD 14,266
|
1,602
-0.9%
|
8.90
|
USD 14,266
|
|
|
2023-05-03 |
2023-05-02 |
S
Sale
|
Carruthers R Michael
Chief Financial Officer
Officer
|
1,336
-7.7%
8.90
USD 11,897
|
1,336
-7.7%
|
8.90
|
USD 11,897
|
|
|
2023-05-03 |
2023-05-02 |
S
Sale
|
Derakhshan Behrad
Chief Business Officer
Officer
|
1,747
-19.9%
8.90
USD 15,557
|
1,747
-19.9%
|
8.90
|
USD 15,557
|
|
|
2023-05-03 |
2023-05-02 |
S
Sale
|
KOCH KEVIN
President and CEO
Executive Director
|
3,203
-30.8%
8.90
USD 28,522
|
3,203
-30.8%
|
8.90
|
USD 28,522
|
|
|
2022-10-05 |
2022-10-03 |
PS
Planned sale
|
MOORE JOHN R
General Counsel
Officer
|
4,730
-61.2%
9.76
USD 46,155
|
4,730
-61.2%
|
9.76
|
USD 46,155
|
|
|
2022-09-16 |
2022-09-16 |
B
Purchase
|
Thompson Peter A.
Non-Executive Director
Large shareholder
|
484,496
+3.6%
10.32
USD 4,999,999
|
484,496
+3.6%
|
10.32
|
USD 4,999,999
|
|
|
2022-09-16 |
2022-09-16 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
484,496
+3.6%
10.32
USD 4,999,999
|
484,496
+3.6%
|
10.32
|
USD 4,999,999
|
|
|
2022-09-16 |
2022-09-14 |
B
Purchase
|
Novo Holdings A/S
Large shareholder
|
484,496
+8.7%
10.32
USD 4,999,999
|
484,496
+8.7%
|
10.32
|
USD 4,999,999
|
|
|
2022-09-08 |
2022-09-06 |
PS
Planned sale
|
MOORE JOHN R
General Counsel
Officer
|
2,351
-43.9%
10.99
USD 25,842
|
2,351
-43.9%
|
10.99
|
USD 25,842
|
|
|
2022-09-08 |
2022-09-06 |
PS
Planned sale
|
MOORE JOHN R
General Counsel
Officer
|
2,379
-30.8%
10.83
USD 25,756
|
2,379
-30.8%
|
10.83
|
USD 25,756
|
|
|
2022-08-05 |
2022-08-03 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
9,232
-75.5%
9.31
USD 85,921
|
9,232
-75.5%
|
9.31
|
USD 85,921
|
|
|
2022-07-07 |
2022-07-06 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
1,046
-25.9%
8.54
USD 8,928
|
1,046
-25.9%
|
8.54
|
USD 8,928
|
|
|
2022-07-07 |
2022-07-05 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
8,186
-73.2%
8.35
USD 68,329
|
8,186
-73.2%
|
8.35
|
USD 68,329
|
|
|
2022-06-21 |
2022-06-21 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
31,078
-91.2%
7.29
USD 226,695
|
31,078
-91.2%
|
7.29
|
USD 226,695
|
|
|
2022-06-21 |
2022-06-17 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
22,127
-88.1%
6.62
USD 146,434
|
22,127
-88.1%
|
6.62
|
USD 146,434
|
|
|
2022-06-21 |
2022-06-16 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
14,722
-83.1%
6.17
USD 90,805
|
14,722
-83.1%
|
6.17
|
USD 90,805
|
|
|
2022-06-15 |
2022-06-15 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
18,075
-85.8%
6.11
USD 110,445
|
18,075
-85.8%
|
6.11
|
USD 110,445
|
|
|
2022-06-15 |
2022-06-15 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
585
-2.7%
6.11
USD 3,575
|
585
-2.7%
|
6.11
|
USD 3,575
|
|
|
2022-06-15 |
2022-06-14 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
3,628
-54.7%
6.02
USD 21,855
|
3,628
-54.7%
|
6.02
|
USD 21,855
|
|
|
2022-06-15 |
2022-06-13 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
4,093
-57.7%
6.01
USD 24,582
|
4,093
-57.7%
|
6.01
|
USD 24,582
|
|
|
2022-06-10 |
2022-06-10 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
7,125
-70.4%
6.05
USD 43,120
|
7,125
-70.4%
|
6.05
|
USD 43,120
|
|
|
2022-06-10 |
2022-06-09 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
7,615
-71.7%
6.49
USD 49,397
|
7,615
-71.7%
|
6.49
|
USD 49,397
|
|
|
2022-06-10 |
2022-06-08 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
12,566
-80.7%
6.63
USD 83,362
|
12,566
-80.7%
|
6.63
|
USD 83,362
|
|
|
2022-06-07 |
2022-06-07 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
17,150
-85.1%
6.61
USD 113,276
|
17,150
-85.1%
|
6.61
|
USD 113,276
|
|
|
2022-06-07 |
2022-06-07 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
973
-24.5%
6.61
USD 6,427
|
973
-24.5%
|
6.61
|
USD 6,427
|
|
|
2022-06-07 |
2022-06-06 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
13,934
-82.3%
6.03
USD 84,085
|
13,934
-82.3%
|
6.03
|
USD 84,085
|
|
|
2022-06-07 |
2022-06-03 |
S
Sale
|
MOORE JOHN R
General Counsel
Officer
|
15,230
-83.5%
6.05
USD 92,198
|
15,230
-83.5%
|
6.05
|
USD 92,198
|
|
|
2022-05-20 |
2022-05-18 |
B
Purchase
|
Thompson Peter A.
Non-Executive Director
Large shareholder
|
138,000
+1.0%
7.21
USD 994,980
|
138,000
+1.0%
|
7.21
|
USD 994,980
|
|
|
2022-05-20 |
2022-05-18 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
138,000
+1.0%
7.21
USD 994,980
|
138,000
+1.0%
|
7.21
|
USD 994,980
|
|
|
2022-05-18 |
2022-05-16 |
PS
Planned sale
|
MOORE JOHN R
General Counsel
Officer
|
10,800
-78.3%
7.42
USD 80,146
|
10,800
-78.3%
|
7.42
|
USD 80,146
|
|
