2012-07-13 |
2012-07-13 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
4,500
-13.9%
2.51
USD 11,298
|
4,500
-13.9%
|
2.51
|
USD 11,298
|
|
2012-07-13 |
2012-07-13 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
474,800
-14.0%
2.51
USD 1,192,033
|
474,800
-14.0%
|
2.51
|
USD 1,192,033
|
|
2012-07-13 |
2012-07-12 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
2,076
-6.0%
2.85
USD 5,916
|
2,076
-6.0%
|
2.85
|
USD 5,916
|
|
2012-07-13 |
2012-07-12 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
218,624
-6.0%
2.85
USD 622,991
|
218,624
-6.0%
|
2.85
|
USD 622,991
|
|
2012-07-13 |
2012-07-11 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
4,792
-12.2%
2.90
USD 13,891
|
4,792
-12.2%
|
2.90
|
USD 13,891
|
|
2012-07-13 |
2012-07-11 |
S
Sale
|
ORBIMED ADVISORS LLC
Large shareholder
|
503,144
-12.2%
2.90
USD 1,458,514
|
503,144
-12.2%
|
2.90
|
USD 1,458,514
|
|
2012-03-16 |
2012-03-16 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
450,000
-24.4%
2.92
USD 1,316,070
|
450,000
-24.4%
|
2.92
|
USD 1,316,070
|
|
2012-03-16 |
2012-03-16 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
450,000
-24.4%
2.92
USD 1,316,070
|
450,000
-24.4%
|
2.92
|
USD 1,316,070
|
|
2012-03-16 |
2012-03-15 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
165,059
-8.2%
2.89
USD 477,136
|
165,059
-8.2%
|
2.89
|
USD 477,136
|
|
2012-03-16 |
2012-03-15 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
165,059
-8.2%
2.89
USD 477,136
|
165,059
-8.2%
|
2.89
|
USD 477,136
|
|
2012-03-16 |
2012-03-14 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
142,941
-6.6%
3.09
USD 441,359
|
142,941
-6.6%
|
3.09
|
USD 441,359
|
|
2012-03-16 |
2012-03-14 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
142,941
-6.6%
3.09
USD 441,359
|
142,941
-6.6%
|
3.09
|
USD 441,359
|
|
2012-03-15 |
2012-03-13 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
275,000
-11.3%
3.20
USD 879,588
|
275,000
-11.3%
|
3.20
|
USD 879,588
|
|
2012-03-15 |
2012-03-13 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
275,000
-11.3%
3.20
USD 879,588
|
275,000
-11.3%
|
3.20
|
USD 879,588
|
|
2011-12-16 |
2011-12-14 |
B
Purchase
|
SENYEI ANDREW E
Non-Executive Director
Large shareholder
|
100,000
+99.0%
3.05
USD 305,000
|
100,000
+99.0%
|
3.05
|
USD 305,000
|
|
2011-12-16 |
2011-12-14 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
100,000
-4.0%
3.05
USD 305,000
|
100,000
-4.0%
|
3.05
|
USD 305,000
|
|
2011-12-16 |
2011-12-14 |
B
Purchase
|
Enterprise Partners Management LLC
Large shareholder
|
100,000
+99.0%
3.05
USD 305,000
|
100,000
+99.0%
|
3.05
|
USD 305,000
|
|
2011-12-16 |
2011-12-14 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
100,000
-4.0%
3.05
USD 305,000
|
100,000
-4.0%
|
3.05
|
USD 305,000
|
|
2011-12-13 |
2011-12-09 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
21,400
-0.8%
3.00
USD 64,224
|
21,400
-0.8%
|
3.00
|
USD 64,224
|
|
2011-12-13 |
2011-12-09 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
21,400
-0.8%
3.00
USD 64,224
|
21,400
-0.8%
|
3.00
|
USD 64,224
|
|
2011-12-09 |
2011-12-08 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
24,525
-1.0%
3.00
USD 73,685
|
24,525
-1.0%
|
3.00
|
USD 73,685
|
|
2011-12-09 |
2011-12-08 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
24,525
-1.0%
3.00
USD 73,685
|
24,525
-1.0%
|
3.00
|
USD 73,685
|
|
2011-12-08 |
2011-12-07 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
55,420
-2.1%
3.09
USD 171,342
|
55,420
-2.1%
|
3.09
|
USD 171,342
|
|
2011-12-08 |
2011-12-07 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
55,420
-2.1%
3.09
USD 171,342
|
55,420
-2.1%
|
3.09
|
USD 171,342
|
|
2011-12-08 |
2011-12-06 |
S
Sale
|
WAITE CHARLES P JR
Non-Executive Director
Large shareholder
|
42,575
-1.6%
3.13
USD 133,170
|
42,575
-1.6%
|
3.13
|
USD 133,170
|
|
2011-12-08 |
2011-12-06 |
S
Sale
|
OVP VENTURE PARTNERS VI LP
Large shareholder
|
42,575
-1.6%
3.13
USD 133,170
|
42,575
-1.6%
|
3.13
|
USD 133,170
|
|
2011-09-22 |
2011-09-21 |
PS
Planned sale
|
REID CLIFFORD A
Chief Executive Officer
Executive Director
|
8,000
-100.0%
6.81
USD 54,441
|
8,000
-100.0%
|
6.81
|
USD 54,441
|
|
2011-09-22 |
2011-09-20 |
PS
Planned sale
|
REID CLIFFORD A
Chief Executive Officer
Executive Director
|
8,000
-100.0%
7.30
USD 58,367
|
8,000
-100.0%
|
7.30
|
USD 58,367
|
|
2011-08-12 |
2011-08-08 |
B
Purchase
|
RAFFEL KEITH
SVP & Chief Commercial Officer
Officer
|
10,000
+inf%
7.94
USD 79,364
|
10,000
+inf%
|
7.94
|
USD 79,364
|
|
2011-05-31 |
2011-05-26 |
B
Purchase
|
DONDERO JAMES D
Large shareholder
|
10,623
+0.4%
12.50
USD 132,788
|
10,623
+0.4%
|
12.50
|
USD 132,788
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
5,687
+17.0%
9.00
USD 51,183
|
5,687
+17.0%
|
9.00
|
USD 51,183
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
ORBIMED ADVISORS LLC
Large shareholder
|
597,091
+17.0%
9.00
USD 5,373,819
|
597,091
+17.0%
|
9.00
|
USD 5,373,819
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
Prospect Venture Partners III L P
Large shareholder
|
333,333
+12.5%
9.00
USD 2,999,997
|
333,333
+12.5%
|
9.00
|
USD 2,999,997
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
ENTERPRISE PARTNERS V L P
Large shareholder
|
111,111
+20.0%
9.00
USD 999,999
|
111,111
+20.0%
|
9.00
|
USD 999,999
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
BARKAS ALEXANDER E
Non-Executive Director
Large shareholder
|
333,333
+12.5%
9.00
USD 2,999,997
|
333,333
+12.5%
|
9.00
|
USD 2,999,997
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
SENYEI ANDREW E
Non-Executive Director
Large shareholder
|
111,111
+20.0%
9.00
USD 999,999
|
111,111
+20.0%
|
9.00
|
USD 999,999
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP
Large shareholder
|
17,124
+17.0%
9.00
USD 154,116
|
17,124
+17.0%
|
9.00
|
USD 154,116
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP
Large shareholder
|
39,386
+17.0%
9.00
USD 354,474
|
39,386
+17.0%
|
9.00
|
USD 354,474
|
|
2010-11-16 |
2010-11-16 |
B
Purchase
|
ESSEX WOODLANDS HEALTH VENTURES FUND VIII LP
Large shareholder
|
546,268
+17.0%
9.00
USD 4,916,412
|
546,268
+17.0%
|
9.00
|
USD 4,916,412
|
|