|
2023-01-31 |
2023-01-27 |
S
Sale
|
PAKIANATHAN DEEPIKA
Non-Executive Director
|
1,172
-100.0%
0.39
USD 452
|
1,172
-100.0%
|
0.39
|
USD 452
|
|
|
2023-01-31 |
2023-01-27 |
S
Sale
|
PAKIANATHAN DEEPIKA
Non-Executive Director
|
120,161
-100.0%
0.39
USD 46,358
|
120,161
-100.0%
|
0.39
|
USD 46,358
|
|
|
2021-11-12 |
2021-11-11 |
S
Sale
|
Orford Keith
Director
Officer
|
48,190
-42.2%
0.88
USD 42,407
|
48,190
-42.2%
|
0.88
|
USD 42,407
|
|
|
2021-11-12 |
2021-11-10 |
S
Sale
|
Orford Keith
Director
Officer
|
30,000
-20.8%
0.86
USD 25,695
|
30,000
-20.8%
|
0.86
|
USD 25,695
|
|
|
2021-11-10 |
2021-11-10 |
B
Purchase
|
DRACHMAN JONATHAN G
Non-Executive Director
|
200,000
+inf%
0.86
USD 171,900
|
200,000
+inf%
|
0.86
|
USD 171,900
|
|
|
2021-11-10 |
2021-11-10 |
B
Purchase
|
Molineaux Christopher
SR. VP, DEVELOPMENT
Officer
|
100,000
+21.9%
0.85
USD 84,670
|
100,000
+21.9%
|
0.85
|
USD 84,670
|
|
|
2021-11-10 |
2021-11-10 |
B
Purchase
|
Molineaux Susan
PRESIDENT & CEO
Executive Director
|
100,000
+21.9%
0.85
USD 84,670
|
100,000
+21.9%
|
0.85
|
USD 84,670
|
|
|
2021-11-09 |
2021-11-09 |
S
Sale
|
Orford Keith
Non-Executive Director
|
51,810
-26.4%
0.84
USD 43,520
|
51,810
-26.4%
|
0.84
|
USD 43,520
|
|
|
2020-12-18 |
2020-12-16 |
PS
Planned sale
|
Orford Keith
Chief Medical Officer
Officer
|
2,447
-18.1%
6.00
USD 14,682
|
2,447
-18.1%
|
6.00
|
USD 14,682
|
|
|
2020-05-26 |
2020-05-21 |
S
Sale
|
BVF PARTNERS L P/IL
Large shareholder
|
192,250
-28.6%
6.00
USD 1,153,500
|
192,250
-28.6%
|
6.00
|
USD 1,153,500
|
|
|
2020-05-26 |
2020-05-21 |
S
Sale
|
BVF PARTNERS L P/IL
Large shareholder
|
1,064,332
-27.8%
6.00
USD 6,385,992
|
1,064,332
-27.8%
|
6.00
|
USD 6,385,992
|
|
|
2020-05-26 |
2020-05-21 |
S
Sale
|
BVF PARTNERS L P/IL
Large shareholder
|
1,027,016
-21.7%
6.00
USD 6,162,096
|
1,027,016
-21.7%
|
6.00
|
USD 6,162,096
|
|
|
2020-04-17 |
2020-04-15 |
PS
Planned sale
|
Wong Stephanie
SR. VP, FINANCE & SECRETARY
Officer
|
5,000
-14.3%
8.00
USD 40,000
|
5,000
-14.3%
|
8.00
|
USD 40,000
|
|
|
2020-02-24 |
2020-02-20 |
PS
Planned sale
|
Orford Keith
Chief Medical Officer
Officer
|
3,021
-26.1%
8.00
USD 24,168
|
3,021
-26.1%
|
8.00
|
USD 24,168
|
|
|
2019-12-26 |
2019-12-23 |
PS
Planned sale
|
Orford Keith
Chief Medical Officer
Officer
|
3,021
-20.7%
6.00
USD 18,126
|
3,021
-20.7%
|
6.00
|
USD 18,126
|
|
|
2019-11-22 |
2019-11-20 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
14,151
+2.1%
3.91
USD 55,353
|
14,151
+2.1%
|
3.91
|
USD 55,353
|
|
|
2019-11-22 |
2019-11-20 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
79,285
+2.1%
3.91
USD 310,131
|
79,285
+2.1%
|
3.91
|
USD 310,131
|
|
|
2019-11-22 |
2019-11-20 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
98,518
+2.1%
3.91
USD 385,363
|
98,518
+2.1%
|
3.91
|
USD 385,363
|
|
|
2019-11-18 |
2019-11-14 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
11,105
+1.7%
3.37
USD 37,424
|
11,105
+1.7%
|
3.37
|
USD 37,424
|
|
|
2019-11-18 |
2019-11-14 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
45,888
+1.2%
3.37
USD 154,643
|
45,888
+1.2%
|
3.37
|
USD 154,643
|
|
|
2019-11-18 |
2019-11-14 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
71,495
+1.6%
3.37
USD 240,938
|
71,495
+1.6%
|
3.37
|
USD 240,938
|
|
|
2019-10-31 |
2019-10-30 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
57,868
+9.8%
2.70
USD 156,244
|
57,868
+9.8%
|
2.70
|
USD 156,244
|
|
|
2019-10-31 |
2019-10-30 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
331,048
+9.8%
2.70
USD 893,830
|
331,048
+9.8%
|
2.70
|
USD 893,830
|
|
|
2019-10-31 |
2019-10-30 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
408,592
+9.8%
2.70
USD 1,103,198
|
408,592
+9.8%
|
2.70
|
USD 1,103,198
|
|
|
2019-10-31 |
2019-10-29 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
116,552
+24.6%
2.60
USD 303,035
|
116,552
+24.6%
|
2.60
|
USD 303,035
|
|
|
2019-10-31 |
2019-10-29 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
610,052
+22.1%
2.60
USD 1,586,135
|
610,052
+22.1%
|
2.60
|
USD 1,586,135
|
|
|
2019-10-31 |
2019-10-29 |
B
Purchase
|
BVF PARTNERS L P/IL
Large shareholder
|
872,373
+26.5%
2.60
USD 2,268,170
|
872,373
+26.5%
|
2.60
|
USD 2,268,170
|
|
|
2019-06-27 |
2019-06-25 |
PP
Planned purchase
|
Molineaux Christopher
SR. VP, DEVELOPMENT
|
51,600
+12.7%
3.88
USD 200,208
|
51,600
+12.7%
|
3.88
|
USD 200,208
|
|
|
2019-06-27 |
2019-06-25 |
PP
Planned purchase
|
Molineaux Susan
PRESIDENT AND CEO
Executive Director
|
51,600
+12.7%
3.88
USD 200,208
|
51,600
+12.7%
|
3.88
|
USD 200,208
|
|
|
2019-06-19 |
2019-06-17 |
PS
Planned sale
|
Orford Keith
Chief Medical Officer
|
417
-3.3%
6.00
USD 2,502
|
417
-3.3%
|
6.00
|
USD 2,502
|
|
|
2019-05-24 |
2019-05-22 |
PS
Planned sale
|
Orford Keith
Chief Medical Officer
|
416
-4.0%
6.00
USD 2,496
|
416
-4.0%
|
6.00
|
USD 2,496
|
|
|
2019-04-17 |
2019-04-15 |
PS
Planned sale
|
Orford Keith
Chief Medical Officer
|
416
-3.8%
6.33
USD 2,633
|
416
-3.8%
|
6.33
|
USD 2,633
|
|
|
2019-03-19 |
2019-03-15 |
PS
Planned sale
|
Orford Keith
Chief Medical Officer
|
417
-3.7%
6.43
USD 2,681
|
417
-3.7%
|
6.43
|
USD 2,681
|
|
|
2019-03-13 |
2019-03-11 |
PS
Planned sale
|
Orford Keith
Chief Medical Officer
Officer
|
1,565
-12.2%
6.00
USD 9,390
|
1,565
-12.2%
|
6.00
|
USD 9,390
|
|
|
2018-10-17 |
2018-10-15 |
PS
Planned sale
|
Orford Keith
SR. VP, CLINICAL DEVELOPMENT
Officer
|
313
-2.9%
6.05
USD 1,894
|
313
-2.9%
|
6.05
|
USD 1,894
|
|
|
2018-10-15 |
2018-10-11 |
PS
Planned sale
|
Orford Keith
SR. VP, CLINICAL DEVELOPMENT
Officer
|
1,252
-10.5%
6.00
USD 7,512
|
1,252
-10.5%
|
6.00
|
USD 7,512
|
|
|
2017-09-28 |
2017-09-28 |
S
Sale
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Large shareholder
|
38,000
-1.1%
15.50
USD 589,000
|
38,000
-1.1%
|
15.50
|
USD 589,000
|
|
|
2017-09-28 |
2017-09-27 |
S
Sale
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Large shareholder
|
186,000
-4.9%
15.59
USD 2,899,740
|
186,000
-4.9%
|
15.59
|
USD 2,899,740
|
|
|
2017-09-28 |
2017-09-26 |
S
Sale
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Large shareholder
|
352,000
-8.5%
15.68
USD 5,519,360
|
352,000
-8.5%
|
15.68
|
USD 5,519,360
|
|
|
2017-07-19 |
2017-07-17 |
PS
Planned sale
|
Wong Stephanie
VP, FINANCE AND SECRETARY
Officer
|
3,552
-25.2%
18.41
USD 65,385
|
3,552
-25.2%
|
18.41
|
USD 65,385
|
|
|
2017-07-19 |
2017-07-17 |
PS
Planned sale
|
Orford Keith
SR. VP, CLINICAL DEVELOPMENT
Officer
|
2,120
-23.6%
18.31
USD 38,823
|
2,120
-23.6%
|
18.31
|
USD 38,823
|
|
|
2017-07-07 |
2017-07-06 |
PS
Planned sale
|
Hecht Curtis
SVP, BUS. & CORP. DEVELOPMENT
Officer
|
700
-4.2%
18.00
USD 12,600
|
700
-4.2%
|
18.00
|
USD 12,600
|
|
|
2017-05-23 |
2017-05-19 |
PS
Planned sale
|
Hecht Curtis
SVP, BUS. & CORP. DEVELOPMENT
Officer
|
650
-4.2%
16.00
USD 10,400
|
650
-4.2%
|
16.00
|
USD 10,400
|
|
|
2017-03-24 |
2017-03-22 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Large shareholder
|
487,804
+13.4%
10.25
USD 4,999,991
|
487,804
+13.4%
|
10.25
|
USD 4,999,991
|
|
|
2017-03-15 |
2017-03-13 |
PS
Planned sale
|
Hecht Curtis
SVP, BUS. & CORP. DEVELOPMENT
|
600
-3.7%
14.00
USD 8,400
|
600
-3.7%
|
14.00
|
USD 8,400
|
|
|
2017-03-06 |
2017-03-02 |
PS
Planned sale
|
Hecht Curtis
See Remarks
|
550
-3.3%
12.00
USD 6,600
|
550
-3.3%
|
12.00
|
USD 6,600
|
|
|
2016-11-17 |
2016-11-16 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP, L.L.C.
Large shareholder
|
500,000
+15.9%
3.15
USD 1,575,000
|
500,000
+15.9%
|
3.15
|
USD 1,575,000
|
|
|
2015-09-24 |
2015-09-23 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
40,168
+1.3%
6.07
USD 243,768
|
40,168
+1.3%
|
6.07
|
USD 243,768
|
|
|
2015-09-24 |
2015-09-22 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
41,800
+1.4%
6.00
USD 250,938
|
41,800
+1.4%
|
6.00
|
USD 250,938
|
|
|
2015-09-24 |
2015-09-22 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
25,000
+0.8%
6.00
USD 149,943
|
25,000
+0.8%
|
6.00
|
USD 149,943
|
|
|
2015-09-08 |
2015-09-04 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
2,300
+0.1%
5.95
USD 13,685
|
2,300
+0.1%
|
5.95
|
USD 13,685
|
|
|
2015-09-08 |
2015-09-03 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
88,000
+3.0%
5.93
USD 521,840
|
88,000
+3.0%
|
5.93
|
USD 521,840
|
|
|
2015-08-28 |
2015-08-28 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
22,000
+0.8%
5.58
USD 122,760
|
22,000
+0.8%
|
5.58
|
USD 122,760
|
|
|
2015-08-28 |
2015-08-28 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
20,700
+0.7%
5.55
USD 114,885
|
20,700
+0.7%
|
5.55
|
USD 114,885
|
|
|
2015-08-28 |
2015-08-27 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
32,400
+1.1%
5.35
USD 173,340
|
32,400
+1.1%
|
5.35
|
USD 173,340
|
|
|
2015-08-28 |
2015-08-27 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
29,089
+1.0%
5.17
USD 150,390
|
29,089
+1.0%
|
5.17
|
USD 150,390
|
|
|
2015-08-28 |
2015-08-27 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
19,578
+0.7%
5.58
USD 109,245
|
19,578
+0.7%
|
5.58
|
USD 109,245
|
|
|
2015-08-28 |
2015-08-27 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
6,253
+0.2%
5.43
USD 33,954
|
6,253
+0.2%
|
5.43
|
USD 33,954
|
|
|
2015-08-28 |
2015-08-27 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
9,848
+0.4%
5.41
USD 53,278
|
9,848
+0.4%
|
5.41
|
USD 53,278
|
|
|
2015-08-28 |
2015-08-26 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
32,058
+1.2%
4.65
USD 149,070
|
32,058
+1.2%
|
4.65
|
USD 149,070
|
|
|
2015-08-28 |
2015-08-26 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
200
+0.0%
4.70
USD 940
|
200
+0.0%
|
4.70
|
USD 940
|
|
|
2014-10-15 |
2014-10-15 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
25,000
+0.9%
6.80
USD 170,000
|
25,000
+0.9%
|
6.80
|
USD 170,000
|
|
|
2014-10-15 |
2014-10-15 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
13,000
+0.5%
7.25
USD 94,250
|
13,000
+0.5%
|
7.25
|
USD 94,250
|
|
|
2014-10-15 |
2014-10-14 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
25,000
+0.9%
6.99
USD 174,750
|
25,000
+0.9%
|
6.99
|
USD 174,750
|
|
|
2014-10-15 |
2014-10-14 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
30,000
+1.1%
7.00
USD 210,000
|
30,000
+1.1%
|
7.00
|
USD 210,000
|
|
|
2014-10-15 |
2014-10-13 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
88,700
+3.4%
6.94
USD 615,578
|
88,700
+3.4%
|
6.94
|
USD 615,578
|
|
|
2014-10-09 |
2014-10-07 |
B
Purchase
|
Delphi Management Partners VIII, L.L.C.
Large shareholder
|
4,835
+26.0%
10.00
USD 48,350
|
4,835
+26.0%
|
10.00
|
USD 48,350
|
|
|
2014-10-09 |
2014-10-07 |
B
Purchase
|
Delphi Management Partners VIII, L.L.C.
Large shareholder
|
495,165
+26.0%
10.00
USD 4,951,650
|
495,165
+26.0%
|
10.00
|
USD 4,951,650
|
|
|
2014-10-09 |
2014-10-07 |
B
Purchase
|
George Jean
Non-Executive Director
Large shareholder
|
300,000
+16.6%
10.00
USD 3,000,000
|
300,000
+16.6%
|
10.00
|
USD 3,000,000
|
|
|
2014-10-09 |
2014-10-07 |
B
Purchase
|
MORGENTHALER VENTURE PARTNERS IX LP
Large shareholder
|
350,000
+19.3%
10.00
USD 3,500,000
|
350,000
+19.3%
|
10.00
|
USD 3,500,000
|
|
|
2014-10-09 |
2014-10-07 |
B
Purchase
|
Christoffersen Ralph E
Non-Executive Director
Large shareholder
|
350,000
+19.3%
10.00
USD 3,500,000
|
350,000
+19.3%
|
10.00
|
USD 3,500,000
|
|
|
2014-10-09 |
2014-10-07 |
B
Purchase
|
Advanced Technology Ventures VIII LP
Large shareholder
|
300,000
+16.6%
10.00
USD 3,000,000
|
300,000
+16.6%
|
10.00
|
USD 3,000,000
|
|
|
2014-10-09 |
2014-10-07 |
B
Purchase
|
PAKIANATHAN DEEPIKA
Non-Executive Director
Large shareholder
|
4,835
+26.0%
10.00
USD 48,350
|
4,835
+26.0%
|
10.00
|
USD 48,350
|
|
|
2014-10-09 |
2014-10-07 |
B
Purchase
|
PAKIANATHAN DEEPIKA
Non-Executive Director
Large shareholder
|
495,165
+26.0%
10.00
USD 4,951,650
|
495,165
+26.0%
|
10.00
|
USD 4,951,650
|
|
|
2014-10-03 |
2014-10-01 |
B
Purchase
|
ADAGE CAPITAL PARTNERS GP LLC
Large shareholder
|
800,000
+44.9%
10.00
USD 8,000,000
|
800,000
+44.9%
|
10.00
|
USD 8,000,000
|
|
