|
2015-03-17 |
2015-03-16 |
PS
Planned sale
|
Stamler David A
Chief Medical Officer
Officer
|
2,600
-72.6%
80.08
USD 208,195
|
2,600
-72.6%
|
80.08
|
USD 208,195
|
|
|
2015-03-17 |
2015-03-16 |
PS
Planned sale
|
Stamler David A
Chief Medical Officer
Officer
|
400
-10.0%
79.55
USD 31,820
|
400
-10.0%
|
79.55
|
USD 31,820
|
|
|
2015-02-17 |
2015-02-13 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
1,047
-1.4%
62.98
USD 65,943
|
1,047
-1.4%
|
62.98
|
USD 65,943
|
|
|
2015-02-17 |
2015-02-13 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
40,786
-1.4%
62.98
USD 2,568,825
|
40,786
-1.4%
|
62.98
|
USD 2,568,825
|
|
|
2015-02-17 |
2015-02-12 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
325
-0.4%
64.00
USD 20,800
|
325
-0.4%
|
64.00
|
USD 20,800
|
|
|
2015-02-17 |
2015-02-12 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
1,696
-2.1%
62.96
USD 106,782
|
1,696
-2.1%
|
62.96
|
USD 106,782
|
|
|
2015-02-17 |
2015-02-12 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
12,675
-0.4%
64.00
USD 811,200
|
12,675
-0.4%
|
64.00
|
USD 811,200
|
|
|
2015-02-17 |
2015-02-12 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
66,138
-2.1%
62.96
USD 4,164,128
|
66,138
-2.1%
|
62.96
|
USD 4,164,128
|
|
|
2015-02-11 |
2015-02-11 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
1,327
-1.6%
61.84
USD 82,062
|
1,327
-1.6%
|
61.84
|
USD 82,062
|
|
|
2015-02-11 |
2015-02-11 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
51,773
-1.6%
61.84
USD 3,201,642
|
51,773
-1.6%
|
61.84
|
USD 3,201,642
|
|
|
2015-02-11 |
2015-02-10 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
530
-0.7%
60.05
USD 31,827
|
530
-0.7%
|
60.05
|
USD 31,827
|
|
|
2015-02-11 |
2015-02-10 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
20,670
-0.6%
60.05
USD 1,241,234
|
20,670
-0.6%
|
60.05
|
USD 1,241,234
|
|
|
2015-02-11 |
2015-02-09 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
246
-0.3%
59.00
USD 14,514
|
246
-0.3%
|
59.00
|
USD 14,514
|
|
|
2015-02-11 |
2015-02-09 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
9,608
-0.3%
59.00
USD 566,872
|
9,608
-0.3%
|
59.00
|
USD 566,872
|
|
|
2015-02-06 |
2015-02-06 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
757
-0.9%
59.48
USD 45,026
|
757
-0.9%
|
59.48
|
USD 45,026
|
|
|
2015-02-06 |
2015-02-06 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
29,522
-0.9%
59.48
USD 1,755,969
|
29,522
-0.9%
|
59.48
|
USD 1,755,969
|
|
|
2015-02-06 |
2015-02-05 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
322
-0.4%
59.51
USD 19,162
|
322
-0.4%
|
59.51
|
USD 19,162
|
|
|
2015-02-06 |
2015-02-05 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
12,578
-0.4%
59.51
USD 748,517
|
12,578
-0.4%
|
59.51
|
USD 748,517
|
|
|
2015-02-06 |
2015-02-04 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
1,250
-1.5%
59.30
USD 74,125
|
1,250
-1.5%
|
59.30
|
USD 74,125
|
|
|
2015-02-06 |
2015-02-04 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
48,750
-1.5%
59.30
USD 2,890,875
|
48,750
-1.5%
|
59.30
|
USD 2,890,875
|
|
|
2015-01-30 |
2015-01-28 |
S
Sale
|
Thomas, McNerney & Partners II, LLC
Non-Executive Director
Large shareholder
|
730,000
-13.1%
53.11
USD 38,770,300
|
730,000
-13.1%
|
53.11
|
USD 38,770,300
|
|
|
2015-01-30 |
2015-01-28 |
S
Sale
|
Zisson Alex
Non-Executive Director
|
730,000
-13.1%
53.11
USD 38,770,300
|
730,000
-13.1%
|
53.11
|
USD 38,770,300
|
|
|
2015-01-28 |
2015-01-28 |
B
Purchase
|
Flynn James E
Large shareholder
|
192,240
+24.6%
56.50
USD 10,861,560
|
192,240
+24.6%
|
56.50
|
USD 10,861,560
|
|
|
2015-01-28 |
2015-01-28 |
B
Purchase
|
Flynn James E
Large shareholder
|
167,760
+24.6%
56.50
USD 9,478,440
|
167,760
+24.6%
|
56.50
|
USD 9,478,440
|
|
|
2015-01-28 |
2015-01-28 |
B
Purchase
|
Flynn James E
Large shareholder
|
566,825
+92.0%
56.50
USD 32,025,613
|
566,825
+92.0%
|
56.50
|
USD 32,025,613
|
|
|
2015-01-28 |
2015-01-28 |
B
Purchase
|
Flynn James E
Large shareholder
|
458,175
+92.5%
56.50
USD 25,886,888
|
458,175
+92.5%
|
56.50
|
USD 25,886,888
|
|
|
2015-01-28 |
2015-01-28 |
S
Sale
|
FERGUSON RODNEY A
Non-Executive Director
Large shareholder
|
270,000
-9.7%
53.11
USD 14,339,700
|
270,000
-9.7%
|
53.11
|
USD 14,339,700
|
|
|
2015-01-28 |
2015-01-28 |
S
Sale
|
Panorama Capital, L.P.
Large shareholder
|
270,000
-9.7%
53.11
USD 14,339,700
|
270,000
-9.7%
|
53.11
|
USD 14,339,700
|
|
|
2015-01-28 |
2015-01-28 |
B
Purchase
|
Flynn James E
Large shareholder
|
115,000
+30.7%
56.50
USD 6,497,500
|
115,000
+30.7%
|
56.50
|
USD 6,497,500
|
|
|
2015-02-17 |
2015-01-08 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
84
-0.1%
49.13
USD 4,127
|
84
-0.1%
|
49.13
|
USD 4,127
|
|
|
2015-02-17 |
2015-01-08 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
3,260
-0.1%
49.13
USD 160,161
|
3,260
-0.1%
|
49.13
|
USD 160,161
|
|
|
2014-12-23 |
2014-12-22 |
PS
Planned sale
|
Stamler David A
Chief Medical Officer
Officer
|
1,100
-52.8%
53.92
USD 59,316
|
1,100
-52.8%
|
53.92
|
USD 59,316
|
|
|
2014-12-23 |
2014-12-22 |
PS
Planned sale
|
Stamler David A
Chief Medical Officer
Officer
|
1,560
-42.8%
53.28
USD 83,118
|
1,560
-42.8%
|
53.28
|
USD 83,118
|
|
|
2014-12-22 |
2014-12-18 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
4,875
-5.1%
50.14
USD 244,433
|
4,875
-5.1%
|
50.14
|
USD 244,433
|
|
|
2014-12-22 |
2014-12-18 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
190,125
-5.1%
50.14
USD 9,532,868
|
190,125
-5.1%
|
50.14
|
USD 9,532,868
|
|
|
2014-10-31 |
2014-10-30 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
197
-0.2%
27.33
USD 5,383
|
197
-0.2%
|
27.33
|
USD 5,383
|
|
|
2014-10-31 |
2014-10-30 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
7,633
-0.2%
27.33
USD 208,582
|
7,633
-0.2%
|
27.33
|
USD 208,582
|
|
|
2014-10-31 |
2014-10-29 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
279
-0.3%
27.02
USD 7,539
|
279
-0.3%
|
27.02
|
USD 7,539
|
|
|
2014-10-31 |
2014-10-29 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
10,891
-0.3%
27.02
USD 294,307
|
10,891
-0.3%
|
27.02
|
USD 294,307
|
|
|
2014-10-29 |
2014-10-28 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
275
-0.3%
26.99
USD 7,422
|
275
-0.3%
|
26.99
|
USD 7,422
|
|
|
2014-10-29 |
2014-10-28 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
10,725
-0.3%
26.99
USD 289,476
|
10,725
-0.3%
|
26.99
|
USD 289,476
|
|
|
2014-10-29 |
2014-10-27 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
87
-0.1%
27.11
USD 2,359
|
87
-0.1%
|
27.11
|
USD 2,359
|
|
|
2014-10-29 |
2014-10-27 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
3,413
-0.1%
27.11
USD 92,541
|
3,413
-0.1%
|
27.11
|
USD 92,541
|
|
|
2014-10-27 |
2014-10-24 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
272
-0.3%
27.09
USD 7,367
|
272
-0.3%
|
27.09
|
USD 7,367
|
|
|
2014-10-27 |
2014-10-24 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
10,628
-0.3%
27.09
USD 287,866
|
10,628
-0.3%
|
27.09
|
USD 287,866
|
|
|
2014-10-27 |
2014-10-23 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
140
-0.1%
26.74
USD 3,743
|
140
-0.1%
|
26.74
|
USD 3,743
|
|
|
2014-10-27 |
2014-10-23 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
5,460
-0.1%
26.74
USD 145,974
|
5,460
-0.1%
|
26.74
|
USD 145,974
|
|
|
2014-10-08 |
2014-10-06 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
178
-0.2%
23.45
USD 4,173
|
178
-0.2%
|
23.45
|
USD 4,173
|
|
|
2014-10-08 |
2014-10-06 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
6,931
-0.2%
23.45
USD 162,497
|
6,931
-0.2%
|
23.45
|
USD 162,497
|
|
|
2014-09-22 |
2014-09-19 |
B
Purchase
|
PROEHL GERALD T
Non-Executive Director
|
1,466
+inf%
21.75
USD 31,885
|
1,466
+inf%
|
21.75
|
USD 31,885
|
|
|
2014-09-08 |
2014-09-05 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
222
-0.2%
23.50
USD 5,217
|
222
-0.2%
|
23.50
|
USD 5,217
|
|
|
2014-09-08 |
2014-09-05 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
8,678
-0.2%
23.50
USD 203,926
|
8,678
-0.2%
|
23.50
|
USD 203,926
|
|
|
2014-09-08 |
2014-09-04 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
417
-0.4%
24.05
USD 10,030
|
417
-0.4%
|
24.05
|
USD 10,030
|
|
|
2014-09-08 |
2014-09-04 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
16,283
-0.4%
24.05
USD 391,634
|
16,283
-0.4%
|
24.05
|
USD 391,634
|
|
|
2014-09-04 |
2014-09-03 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
312
-0.3%
23.09
USD 7,205
|
312
-0.3%
|
23.09
|
USD 7,205
|
|
|
2014-09-04 |
2014-09-03 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
12,188
-0.3%
23.09
USD 281,467
|
12,188
-0.3%
|
23.09
|
USD 281,467
|
|
|
2014-09-04 |
2014-09-02 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
255
-0.3%
23.07
USD 5,883
|
255
-0.3%
|
23.07
|
USD 5,883
|
|
|
2014-09-04 |
2014-09-02 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
9,945
-0.3%
23.07
USD 229,425
|
9,945
-0.3%
|
23.07
|
USD 229,425
|
|
|
2014-09-03 |
2014-08-29 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
217
-0.2%
22.59
USD 4,903
|
217
-0.2%
|
22.59
|
USD 4,903
|
|
|
2014-09-03 |
2014-08-29 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
8,483
-0.2%
22.59
USD 191,650
|
8,483
-0.2%
|
22.59
|
USD 191,650
|
|
|
2014-08-29 |
2014-08-28 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
305
-0.3%
22.24
USD 6,784
|
305
-0.3%
|
22.24
|
USD 6,784
|
|
|
2014-08-29 |
2014-08-28 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
11,895
-0.3%
22.24
USD 264,564
|
11,895
-0.3%
|
22.24
|
USD 264,564
|
|
|
2014-08-29 |
2014-08-27 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
435
-0.5%
21.88
USD 9,517
|
435
-0.5%
|
21.88
|
USD 9,517
|
|
|
2014-08-29 |
2014-08-27 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
16,965
-0.5%
21.88
USD 371,148
|
16,965
-0.5%
|
21.88
|
USD 371,148
|
|
|
2014-08-28 |
2014-08-26 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
157
-0.2%
21.35
USD 3,352
|
157
-0.2%
|
21.35
|
USD 3,352
|
|
|
2014-08-28 |
2014-08-26 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
6,143
-0.2%
21.35
USD 131,165
|
6,143
-0.2%
|
21.35
|
USD 131,165
|
|
|
2014-08-27 |
2014-08-25 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
135
-0.1%
20.81
USD 2,809
|
135
-0.1%
|
20.81
|
USD 2,809
|
|
|
2014-08-27 |
2014-08-25 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
5,265
-0.1%
20.81
USD 109,549
|
5,265
-0.1%
|
20.81
|
USD 109,549
|
|
|
2014-08-26 |
2014-08-22 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
42
-0.0%
20.56
USD 863
|
42
-0.0%
|
20.56
|
USD 863
|
|
|
2014-08-26 |
2014-08-22 |
S
Sale
|
CMEA Ventures VII LP
Large shareholder
|
1,658
-0.0%
20.56
USD 34,085
|
1,658
-0.0%
|
20.56
|
USD 34,085
|
|
|
2014-07-16 |
2014-07-16 |
B
Purchase
|
GREER R SCOTT
Non-Executive Director
|
5,190
+259.5%
19.25
USD 99,908
|
5,190
+259.5%
|
19.25
|
USD 99,908
|
|
|
2014-09-09 |
2014-05-14 |
S
Sale
|
Thomas, McNerney & Partners II L.P.
Large shareholder
|
12,400
-0.2%
20.60
USD 255,415
|
12,400
-0.2%
|
20.60
|
USD 255,415
|
|
|
2014-09-09 |
2014-05-14 |
S
Sale
|
Zisson Alex
Non-Executive Director
Large shareholder
|
12,400
-0.2%
20.60
USD 255,415
|
12,400
-0.2%
|
20.60
|
USD 255,415
|
|
|
2014-10-01 |
2014-02-10 |
B
Purchase
|
Thomas, McNerney & Partners II, LLC
Non-Executive Director
Large shareholder
|
82,475
+1.6%
12.00
USD 989,700
|
82,475
+1.6%
|
12.00
|
USD 989,700
|
|
|
2014-02-12 |
2014-02-10 |
B
Purchase
|
CMEA Ventures VII LP
Large shareholder
|
2,688
+2.9%
12.00
USD 32,256
|
2,688
+2.9%
|
12.00
|
USD 32,256
|
|
