|
2017-09-20 |
2017-09-20 |
B
Purchase
|
THOMPSON JOHN CRAIG
President & CEO
|
8,550
+75.7%
1.32
USD 11,286
|
8,550
+75.7%
|
1.32
|
USD 11,286
|
|
|
2017-09-07 |
2017-09-07 |
B
Purchase
|
TRUEX PAUL F
|
5,000
+42.4%
1.34
USD 6,700
|
5,000
+42.4%
|
1.34
|
USD 6,700
|
|
|
2015-11-18 |
2015-11-13 |
PS
Planned sale
|
Hislop Colin
Chief Medical Officer
Officer
|
12,500
-39.5%
5.31
USD 66,341
|
12,500
-39.5%
|
5.31
|
USD 66,341
|
|
|
2015-11-12 |
2015-11-11 |
S
Sale
|
Hislop Colin
Chief Medical Officer
Officer
|
5,000
-20.7%
5.38
USD 26,900
|
5,000
-20.7%
|
5.38
|
USD 26,900
|
|
|
2013-06-26 |
2013-06-24 |
B
Purchase
|
Thompson David E.
Non-Executive Director
|
100,000
+354.6%
0.53
USD 53,000
|
100,000
+354.6%
|
0.53
|
USD 53,000
|
|
|
2013-06-04 |
2013-05-31 |
B
Purchase
|
DZIURZYNSKI BOGDAN
Non-Executive Director
|
10,000
+inf%
0.59
USD 5,900
|
10,000
+inf%
|
0.59
|
USD 5,900
|
|
|
2013-02-01 |
2013-01-30 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
5,700,000
+323.5%
0.66
USD 3,762,000
|
5,700,000
+323.5%
|
0.66
|
USD 3,762,000
|
|
|
2013-01-29 |
2013-01-25 |
B
Purchase
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
1,762,000
+inf%
0.65
USD 1,142,481
|
1,762,000
+inf%
|
0.65
|
USD 1,142,481
|
|
|
2012-07-03 |
2012-06-29 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
1,283,300
-100.0%
0.73
USD 942,071
|
1,283,300
-100.0%
|
0.73
|
USD 942,071
|
|
|
2012-07-02 |
2012-06-29 |
B
Purchase
|
HENNEY CHRISTOPHER S
Non-Executive Director
|
100,000
+inf%
0.75
USD 74,930
|
100,000
+inf%
|
0.75
|
USD 74,930
|
|
|
2012-07-02 |
2012-06-29 |
B
Purchase
|
HENNEY CHRISTOPHER S
Non-Executive Director
|
100,000
+97.6%
0.75
USD 74,930
|
100,000
+97.6%
|
0.75
|
USD 74,930
|
|
|
2012-07-02 |
2012-06-29 |
B
Purchase
|
TRUEX PAUL F
President and CEO
Executive Director
|
20,000
+3.2%
0.76
USD 15,200
|
20,000
+3.2%
|
0.76
|
USD 15,200
|
|
|
2012-03-22 |
2012-03-22 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
1,306,700
-50.5%
2.40
USD 3,140,131
|
1,306,700
-50.5%
|
2.40
|
USD 3,140,131
|
|
|
2012-03-22 |
2012-03-21 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
125,000
-4.6%
2.87
USD 358,313
|
125,000
-4.6%
|
2.87
|
USD 358,313
|
|
|
2012-03-22 |
2012-03-20 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
116,800
-4.1%
2.90
USD 338,638
|
116,800
-4.1%
|
2.90
|
USD 338,638
|
|
|
2012-01-03 |
2011-12-30 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
280
-0.6%
6.23
USD 1,743
|
280
-0.6%
|
6.23
|
USD 1,743
|
|
|
2012-01-03 |
2011-12-30 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
4,090
-0.6%
6.23
USD 25,460
|
4,090
-0.6%
|
6.23
|
USD 25,460
|
|
|
2012-01-03 |
2011-12-30 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
280
-0.6%
6.23
USD 1,743
|
280
-0.6%
|
6.23
|
USD 1,743
|
|
|
2012-01-03 |
2011-12-30 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
4,090
-0.6%
6.23
USD 25,460
|
4,090
-0.6%
|
6.23
|
USD 25,460
|
|
|
2012-01-03 |
2011-12-30 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
20,630
-0.6%
6.23
USD 128,422
|
20,630
-0.6%
|
6.23
|
USD 128,422
|
|
|
2012-01-03 |
2011-12-30 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
20,630
-0.6%
6.23
USD 128,422
|
20,630
-0.6%
|
6.23
|
USD 128,422
|
|
|
2011-12-23 |
2011-12-22 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
280
-0.6%
6.22
USD 1,743
|
280
-0.6%
|
6.22
|
USD 1,743
|
|
|
2011-12-23 |
2011-12-22 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
4,090
-0.6%
6.22
USD 25,457
|
4,090
-0.6%
|
6.22
|
USD 25,457
|
|
|
2011-12-23 |
2011-12-22 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
20,630
-0.6%
6.22
USD 128,405
|
20,630
-0.6%
|
6.22
|
USD 128,405
|
|
|
2011-12-23 |
2011-12-22 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
280
-0.6%
6.22
USD 1,743
|
280
-0.6%
|
6.22
|
USD 1,743
|
|
|
2011-12-23 |
2011-12-22 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
4,090
-0.6%
6.22
USD 25,457
|
4,090
-0.6%
|
6.22
|
USD 25,457
|
|
|
2011-12-23 |
2011-12-22 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
20,630
-0.6%
6.22
USD 128,405
|
20,630
-0.6%
|
6.22
|
USD 128,405
|
|
|
2011-12-23 |
2011-12-21 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
280
-0.6%
6.51
USD 1,823
|
280
-0.6%
|
6.51
|
USD 1,823
|
|
|
2011-12-23 |
2011-12-21 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
4,090
-0.6%
6.51
USD 26,629
|
4,090
-0.6%
|
6.51
|
USD 26,629
|
|
|
2011-12-23 |
2011-12-21 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
280
-0.6%
6.51
USD 1,823
|
280
-0.6%
|
6.51
|
USD 1,823
|
|
|
2011-12-23 |
2011-12-21 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
4,090
-0.6%
6.51
USD 26,629
|
4,090
-0.6%
|
6.51
|
USD 26,629
|
|
|
2011-12-23 |
2011-12-21 |
S
Sale
|
HEALY JAMES
Non-Executive Director
Large shareholder
|
20,630
-0.6%
6.51
USD 134,318
|
20,630
-0.6%
|
6.51
|
USD 134,318
|
|
|
2011-12-23 |
2011-12-21 |
S
Sale
|
SOFINNOVA VENTURE PARTNERS VI L P
Large shareholder
|
20,630
-0.6%
6.51
USD 134,318
|
20,630
-0.6%
|
6.51
|
USD 134,318
|
|
|
2011-12-13 |
2011-12-13 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
16,200
-0.6%
6.50
USD 105,300
|
16,200
-0.6%
|
6.50
|
USD 105,300
|
|
|
2011-12-13 |
2011-12-09 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
|
40,000
-1.4%
6.75
USD 270,000
|
40,000
-1.4%
|
6.75
|
USD 270,000
|
|
|
2011-11-18 |
2011-11-18 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
3,000
-0.1%
6.50
USD 19,500
|
3,000
-0.1%
|
6.50
|
USD 19,500
|
|
|
2011-11-18 |
2011-11-17 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
24,000
-0.8%
6.67
USD 160,080
|
24,000
-0.8%
|
6.67
|
USD 160,080
|
|
|
2011-11-18 |
2011-11-16 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
25,000
-0.9%
6.87
USD 171,750
|
25,000
-0.9%
|
6.87
|
USD 171,750
|
|
|
2011-11-17 |
2011-11-15 |
PS
Planned sale
|
TRUEX PAUL F
President and CEO
Executive Director
|
15,000
-2.2%
6.96
USD 104,352
|
15,000
-2.2%
|
6.96
|
USD 104,352
|
|
|
2011-11-17 |
2011-11-15 |
PS
Planned sale
|
TRUEX PAUL F
President and CEO
Executive Director
|
15,000
-2.2%
6.96
USD 104,352
|
15,000
-2.2%
|
6.96
|
USD 104,352
|
|
|
2011-11-15 |
2011-11-15 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
50,000
-1.7%
6.93
USD 346,500
|
50,000
-1.7%
|
6.93
|
USD 346,500
|
|
|
2011-11-15 |
2011-11-14 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
5,000
-0.2%
6.95
USD 34,750
|
5,000
-0.2%
|
6.95
|
USD 34,750
|
|
|
2011-11-15 |
2011-11-11 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
5,000
-0.2%
7.14
USD 35,700
|
5,000
-0.2%
|
7.14
|
USD 35,700
|
|
|
2011-11-10 |
2011-11-08 |
S
Sale
|
Hislop Colin
Chief Medical Officer
Officer
|
15,000
-20.6%
6.74
USD 101,163
|
15,000
-20.6%
|
6.74
|
USD 101,163
|
|
|
2011-10-25 |
2011-10-21 |
PS
Planned sale
|
TRUEX PAUL F
President and CEO
Executive Director
|
11,879
-1.8%
6.25
USD 74,244
|
11,879
-1.8%
|
6.25
|
USD 74,244
|
|
|
2011-08-04 |
2011-08-02 |
PS
Planned sale
|
LOWE CHRISTOPHER P.
Chief Financial Officer & CBO
Officer
|
300
-6.1%
7.93
USD 2,378
|
300
-6.1%
|
7.93
|
USD 2,378
|
|
|
2011-06-20 |
2011-06-16 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
10
-0.1%
8.67
USD 87
|
10
-0.1%
|
8.67
|
USD 87
|
|
|
2011-06-20 |
2011-06-16 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
281
-0.1%
8.67
USD 2,436
|
281
-0.1%
|
8.67
|
USD 2,436
|
|
|
2011-06-20 |
2011-06-16 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
2,809
-0.1%
8.67
USD 24,354
|
2,809
-0.1%
|
8.67
|
USD 24,354
|
|
|
2011-06-17 |
2011-06-15 |
PS
Planned sale
|
TRUEX PAUL F
President and CEO
Executive Director
|
15,000
-2.2%
8.30
USD 124,539
|
15,000
-2.2%
|
8.30
|
USD 124,539
|
|
|
2011-06-15 |
2011-06-14 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
2
-0.0%
8.81
USD 18
|
2
-0.0%
|
8.81
|
USD 18
|
|
|
2011-06-15 |
2011-06-14 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
63
-0.0%
8.81
USD 555
|
63
-0.0%
|
8.81
|
USD 555
|
|
|
2011-06-15 |
2011-06-14 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
634
-0.0%
8.81
USD 5,586
|
634
-0.0%
|
8.81
|
USD 5,586
|
|
|
2011-06-15 |
2011-06-13 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
4
-0.0%
8.80
USD 35
|
4
-0.0%
|
8.80
|
USD 35
|
|
|
2011-06-15 |
2011-06-13 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
118
-0.0%
8.80
USD 1,038
|
118
-0.0%
|
8.80
|
USD 1,038
|
|
|
2011-06-15 |
2011-06-13 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
1,178
-0.0%
8.80
USD 10,366
|
1,178
-0.0%
|
8.80
|
USD 10,366
|
|
|
2011-06-10 |
2011-06-10 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
30,000
-1.0%
8.18
USD 245,400
|
30,000
-1.0%
|
8.18
|
USD 245,400
|
|
|
2011-06-10 |
2011-06-09 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
37,000
-1.2%
8.11
USD 300,070
|
37,000
-1.2%
|
8.11
|
USD 300,070
|
|
|
2011-06-10 |
2011-06-08 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
33,000
-1.1%
8.02
USD 264,660
|
33,000
-1.1%
|
8.02
|
USD 264,660
|
|
|
2011-05-31 |
2011-05-26 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
16
-0.1%
8.60
USD 138
|
16
-0.1%
|
8.60
|
USD 138
|
|
|
2011-05-31 |
2011-05-26 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
435
-0.1%
8.60
USD 3,741
|
435
-0.1%
|
8.60
|
USD 3,741
|
|
|
2011-05-31 |
2011-05-26 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
4,349
-0.1%
8.60
USD 37,401
|
4,349
-0.1%
|
8.60
|
USD 37,401
|
|
|
2011-05-27 |
2011-05-25 |
S
Sale
|
ORBIMED ADVISORS LLC
Non-Executive Director
Large shareholder
|
4,800
8.65
USD 41,520
|
4,800
|
8.65
|
USD 41,520
|
|
|
2011-05-25 |
2011-05-25 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
108
-0.6%
8.67
USD 936
|
108
-0.6%
|
8.67
|
USD 936
|
|
|
2011-05-25 |
2011-05-25 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
2,970
-0.6%
8.67
USD 25,750
|
2,970
-0.6%
|
8.67
|
USD 25,750
|
|
|
2011-05-25 |
2011-05-25 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
29,672
-0.6%
8.67
USD 257,256
|
29,672
-0.6%
|
8.67
|
USD 257,256
|
|
|
2011-05-25 |
2011-05-24 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
172
-1.0%
8.42
USD 1,448
|
172
-1.0%
|
8.42
|
USD 1,448
|
|
|
2011-05-25 |
2011-05-24 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
4,734
-1.0%
8.42
USD 39,860
|
4,734
-1.0%
|
8.42
|
USD 39,860
|
|
|
2011-05-25 |
2011-05-24 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
47,290
-1.0%
8.42
USD 398,182
|
47,290
-1.0%
|
8.42
|
USD 398,182
|
|
|
2011-05-25 |
2011-05-23 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
88
-0.5%
8.18
USD 720
|
88
-0.5%
|
8.18
|
USD 720
|
|
|
2011-05-25 |
2011-05-23 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
2,422
-0.5%
8.18
USD 19,812
|
2,422
-0.5%
|
8.18
|
USD 19,812
|
|
|
2011-05-25 |
2011-05-23 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
24,193
-0.5%
8.18
USD 197,899
|
24,193
-0.5%
|
8.18
|
USD 197,899
|
|
|
2011-05-19 |
2011-05-19 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
412
-2.2%
8.03
USD 3,308
|
412
-2.2%
|
8.03
|
USD 3,308
|
|
|
2011-05-19 |
2011-05-19 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
11,337
-2.2%
8.03
USD 91,036
|
11,337
-2.2%
|
8.03
|
USD 91,036
|
|
|
2011-05-19 |
2011-05-19 |
S
Sale
|
VANTAGEPOINT VENTURE ASSOCIATES IV LLC
Large shareholder
|
113,251
-2.2%
8.03
USD 909,406
|
113,251
-2.2%
|
8.03
|
USD 909,406
|
|
