|
2009-12-30 |
2009-12-29 |
V
Verkauf
|
STUPPIN JOHN B
Nicht geschäftsführender Verwaltungsratsmitglied
|
5.608
-3.0%
0,12
673 USD
|
5.608
-3.0%
|
0,12
|
673 USD
|
|
|
2009-10-26 |
2009-10-26 |
K
Kauf
|
Firefly Value Partners, LP
Large shareholder
|
81.561
+3.6%
0,90
73.397 USD
|
81.561
+3.6%
|
0,90
|
73.397 USD
|
|
|
2009-10-26 |
2009-10-26 |
K
Kauf
|
Firefly Value Partners, LP
Large shareholder
|
99.365
+3.6%
0,90
89.419 USD
|
99.365
+3.6%
|
0,90
|
89.419 USD
|
|
|
2009-10-26 |
2009-10-22 |
K
Kauf
|
Firefly Value Partners, LP
Large shareholder
|
135.442
+6.4%
0,91
123.022 USD
|
135.442
+6.4%
|
0,91
|
123.022 USD
|
|
|
2009-10-26 |
2009-10-22 |
K
Kauf
|
Firefly Value Partners, LP
Large shareholder
|
165.007
+6.4%
0,91
149.876 USD
|
165.007
+6.4%
|
0,91
|
149.876 USD
|
|
|
2009-10-23 |
2009-10-21 |
V
Verkauf
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Large shareholder
|
2.692.493
-89.0%
0,91
2.450.169 USD
|
2.692.493
-89.0%
|
0,91
|
2.450.169 USD
|
|
|
2009-10-23 |
2009-10-21 |
V
Verkauf
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Large shareholder
|
777.408
-20.4%
0,91
707.441 USD
|
777.408
-20.4%
|
0,91
|
707.441 USD
|
|
|
2009-10-23 |
2009-10-21 |
V
Verkauf
|
BVF PARTNERS L P/IL
Direct Beneficial Owner
Large shareholder
|
1.136.494
-23.0%
0,91
1.034.210 USD
|
1.136.494
-23.0%
|
0,91
|
1.034.210 USD
|
|
|
2009-02-12 |
2008-12-17 |
V
Verkauf
|
FREIMAN PAUL E
Former officer and director
|
66
-0.4%
0,21
14 USD
|
66
-0.4%
|
0,21
|
14 USD
|
|
|
2009-02-12 |
2008-12-17 |
V
Verkauf
|
FREIMAN PAUL E
Former officer and director
|
400
-2.6%
0,21
84 USD
|
400
-2.6%
|
0,21
|
84 USD
|
|
|
2009-02-12 |
2008-12-16 |
V
Verkauf
|
FREIMAN PAUL E
Former officer and director
|
30
-0.2%
0,58
17 USD
|
30
-0.2%
|
0,58
|
17 USD
|
|
|
2009-02-12 |
2008-12-16 |
V
Verkauf
|
FREIMAN PAUL E
Former officer and director
|
970
-5.9%
0,56
543 USD
|
970
-5.9%
|
0,56
|
543 USD
|
|
|
2009-02-12 |
2008-12-10 |
V
Verkauf
|
FREIMAN PAUL E
Former officer and director
|
1.000
-5.8%
0,61
610 USD
|
1.000
-5.8%
|
0,61
|
610 USD
|
|
|
2008-11-18 |
2008-11-14 |
V
Verkauf
|
J P MORGAN CHASE & CO
Large shareholder
|
2.962.340
-100.0%
0,48
1.410.666 USD
|
2.962.340
-100.0%
|
0,48
|
1.410.666 USD
|
|
|
2008-11-14 |
2008-11-12 |
K
Kauf
|
Wasiewski Warren W
Vice President, CMO
Führungsperson
|
10.000
+inf%
0,66
6.600 USD
|
10.000
+inf%
|
0,66
|
6.600 USD
|
|
|
2008-11-13 |
2008-11-11 |
K
Kauf
|
Fletcher William A
Nicht geschäftsführender Verwaltungsratsmitglied
|
10.000
+17.1%
0,66
6.600 USD
|
10.000
+17.1%
|
0,66
|
6.600 USD
|
|
|
2008-10-30 |
2008-10-29 |
K
Kauf
|
Fletcher William A
Nicht geschäftsführender Verwaltungsratsmitglied
|
5.000
+9.3%
0,65
3.250 USD
|
5.000
+9.3%
|
0,65
|
3.250 USD
|
|
|
2008-10-30 |
2008-10-28 |
K
Kauf
|
Fletcher William A
Nicht geschäftsführender Verwaltungsratsmitglied
|
10.000
+22.9%
0,70
7.000 USD
|
10.000
+22.9%
|
0,70
|
7.000 USD
|
|
|
2008-10-23 |
2008-10-22 |
K
Kauf
|
LOAR MATTHEW M
VP and Chief Financial Officer
Führungsperson
|
25.000
+inf%
0,75
18.750 USD
|
25.000
+inf%
|
0,75
|
18.750 USD
|
|
|
2008-10-16 |
2008-10-15 |
K
Kauf
|
STUPPIN JOHN B
Nicht geschäftsführender Verwaltungsratsmitglied
|
1.000
+0.6%
0,87
870 USD
|
1.000
+0.6%
|
0,87
|
870 USD
|
|
|
2008-10-16 |
2008-10-15 |
K
Kauf
|
STUPPIN JOHN B
Nicht geschäftsführender Verwaltungsratsmitglied
|
9.000
+5.5%
0,85
7.650 USD
|
9.000
+5.5%
|
0,85
|
7.650 USD
|
|
|
2008-10-20 |
2008-10-08 |
V
Verkauf
|
J P MORGAN CHASE & CO
Large shareholder
|
158.300
-5.1%
0,44
69.652 USD
|
158.300
-5.1%
|
0,44
|
69.652 USD
|
|
|
2008-10-20 |
2008-10-07 |
V
Verkauf
|
J P MORGAN CHASE & CO
Large shareholder
|
211.100
-6.3%
0,50
105.550 USD
|
211.100
-6.3%
|
0,50
|
105.550 USD
|
|
|
2008-10-20 |
2008-10-06 |
V
Verkauf
|
J P MORGAN CHASE & CO
Large shareholder
|
3.304
-0.1%
0,47
1.553 USD
|
3.304
-0.1%
|
0,47
|
1.553 USD
|
|
|
2008-10-20 |
2008-10-03 |
V
Verkauf
|
J P MORGAN CHASE & CO
Large shareholder
|
17.900
-0.5%
0,55
9.845 USD
|
17.900
-0.5%
|
0,55
|
9.845 USD
|
|
|
2008-10-20 |
2008-10-02 |
V
Verkauf
|
J P MORGAN CHASE & CO
Large shareholder
|
41.550
-1.2%
0,53
22.022 USD
|
41.550
-1.2%
|
0,53
|
22.022 USD
|
|
|
2008-10-20 |
2008-10-01 |
V
Verkauf
|
J P MORGAN CHASE & CO
Large shareholder
|
24.320
-0.7%
0,66
16.051 USD
|
24.320
-0.7%
|
0,66
|
16.051 USD
|
|
|
2008-10-20 |
2008-09-30 |
V
Verkauf
|
J P MORGAN CHASE & CO
Large shareholder
|
2.700
-0.1%
0,65
1.755 USD
|
2.700
-0.1%
|
0,65
|
1.755 USD
|
|
|
2008-10-20 |
2008-09-29 |
V
Verkauf
|
J P MORGAN CHASE & CO
Large shareholder
|
29.150
-0.8%
0,63
18.365 USD
|
29.150
-0.8%
|
0,63
|
18.365 USD
|
|
|
2008-10-20 |
2008-09-26 |
V
Verkauf
|
J P MORGAN CHASE & CO
Large shareholder
|
71.100
-2.0%
0,72
51.192 USD
|
71.100
-2.0%
|
0,72
|
51.192 USD
|
|
|
2008-10-20 |
2008-09-25 |
V
Verkauf
|
J P MORGAN CHASE & CO
Large shareholder
|
163.567
-4.4%
0,78
127.582 USD
|
163.567
-4.4%
|
0,78
|
127.582 USD
|
|
|
2008-10-20 |
2008-09-24 |
V
Verkauf
|
J P MORGAN CHASE & CO
Large shareholder
|
38.423
-1.0%
0,89
34.196 USD
|
38.423
-1.0%
|
0,89
|
34.196 USD
|
|
|
2008-01-03 |
2007-12-31 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
50.000
+1.0%
2,88
144.000 USD
|
50.000
+1.0%
|
2,88
|
144.000 USD
|
|
|
2008-01-02 |
2007-12-31 |
V
Verkauf
|
KASPER F VAN
Nicht geschäftsführender Verwaltungsratsmitglied
|
100
-0.2%
2,91
291 USD
|
100
-0.2%
|
2,91
|
291 USD
|
|
|
2008-01-02 |
2007-12-31 |
V
Verkauf
|
KASPER F VAN
Nicht geschäftsführender Verwaltungsratsmitglied
|
14.119
-24.4%
2,90
40.945 USD
|
14.119
-24.4%
|
2,90
|
40.945 USD
|
|
|
2008-01-02 |
2007-12-31 |
V
Verkauf
|
KASPER F VAN
Nicht geschäftsführender Verwaltungsratsmitglied
|
5.780
-9.1%
2,92
16.878 USD
|
5.780
-9.1%
|
2,92
|
16.878 USD
|
|
|
2007-12-28 |
2007-12-28 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
16.400
+0.3%
2,94
48.186 USD
|
16.400
+0.3%
|
2,94
|
48.186 USD
|
|
|
2007-12-28 |
2007-12-27 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
24.800
+0.5%
2,96
73.443 USD
|
24.800
+0.5%
|
2,96
|
73.443 USD
|
|
|
2007-12-28 |
2007-12-26 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
7.200
+0.1%
3,00
21.599 USD
|
7.200
+0.1%
|
3,00
|
21.599 USD
|
|
|
2007-12-21 |
2007-12-20 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
6.100
+0.1%
3,00
18.300 USD
|
6.100
+0.1%
|
3,00
|
18.300 USD
|
|
|
2007-12-21 |
2007-12-19 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
26.700
+0.6%
3,00
80.100 USD
|
26.700
+0.6%
|
3,00
|
80.100 USD
|
|
|
2007-12-18 |
2007-12-18 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
50.000
+1.0%
3,00
150.000 USD
|
50.000
+1.0%
|
3,00
|
150.000 USD
|
|
|
2007-12-18 |
2007-12-17 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
25.000
+0.5%
3,00
75.000 USD
|
25.000
+0.5%
|
3,00
|
75.000 USD
|
|
|
2007-12-18 |
2007-12-14 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
50.000
+1.1%
2,99
149.500 USD
|
50.000
+1.1%
|
2,99
|
149.500 USD
|
|
|
2007-12-18 |
2007-12-13 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
25.000
+0.5%
3,00
75.000 USD
|
25.000
+0.5%
|
3,00
|
75.000 USD
|
|
|
2007-12-18 |
2007-12-12 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
50.000
+1.1%
3,00
150.000 USD
|
50.000
+1.1%
|
3,00
|
150.000 USD
|
|
|
2007-12-11 |
2007-12-11 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
50.000
+1.1%
3,00
150.000 USD
|
50.000
+1.1%
|
3,00
|
150.000 USD
|
|
|
2007-12-11 |
2007-12-10 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
101.300
+2.3%
2,98
301.651 USD
|
101.300
+2.3%
|
2,98
|
301.651 USD
|
|
|
2007-12-11 |
2007-12-07 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
52.000
+1.2%
3,00
155.901 USD
|
52.000
+1.2%
|
3,00
|
155.901 USD
|
|
|
2007-12-05 |
2007-12-03 |
K
Kauf
|
STUPPIN JOHN B
Nicht geschäftsführender Verwaltungsratsmitglied
|
7.000
+4.4%
3,26
22.820 USD
|
7.000
+4.4%
|
3,26
|
22.820 USD
|
|
|
2007-12-05 |
2007-12-03 |
K
Kauf
|
STUPPIN JOHN B
Nicht geschäftsführender Verwaltungsratsmitglied
|
7.800
+5.2%
3,32
25.896 USD
|
7.800
+5.2%
|
3,32
|
25.896 USD
|
|
|
2007-12-05 |
2007-12-03 |
K
Kauf
|
STUPPIN JOHN B
Nicht geschäftsführender Verwaltungsratsmitglied
|
200
+0.1%
3,31
662 USD
|
200
+0.1%
|
3,31
|
662 USD
|
|
|
2007-12-05 |
2007-12-03 |
K
Kauf
|
STUPPIN JOHN B
Nicht geschäftsführender Verwaltungsratsmitglied
|
2.000
+1.4%
3,30
6.600 USD
|
2.000
+1.4%
|
3,30
|
6.600 USD
|
|
|
2007-12-05 |
2007-12-03 |
K
Kauf
|
FREIMAN PAUL E
President and CEO
Geschäftsführender Verwaltungsratsmitglied
|
3.000
+20.9%
3,30
9.900 USD
|
3.000
+20.9%
|
3,30
|
9.900 USD
|
|
|
2007-11-29 |
2007-11-28 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
336.000
+8.2%
2,71
910.560 USD
|
336.000
+8.2%
|
2,71
|
910.560 USD
|
|
|
2007-11-29 |
2007-11-27 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
116.303
+2.9%
2,70
314.018 USD
|
116.303
+2.9%
|
2,70
|
314.018 USD
|
|
|
2007-11-26 |
2007-11-26 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
20.500
+0.5%
2,58
52.890 USD
|
20.500
+0.5%
|
2,58
|
52.890 USD
|
|
|
2007-11-26 |
2007-11-21 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
188.988
+5.0%
2,40
453.571 USD
|
188.988
+5.0%
|
2,40
|
453.571 USD
|
|
|
2007-11-19 |
2007-11-19 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
23.200
+0.6%
2,49
57.875 USD
|
23.200
+0.6%
|
2,49
|
57.875 USD
|
|
|
2007-11-19 |
2007-11-15 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
29.700
+0.8%
2,46
73.166 USD
|
29.700
+0.8%
|
2,46
|
73.166 USD
|
|
|
2007-11-15 |
2007-11-14 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
8.600
+0.2%
2,40
20.640 USD
|
8.600
+0.2%
|
2,40
|
20.640 USD
|
|
|
2007-11-15 |
2007-11-13 |
K
Kauf
|
HIGHLAND CAPITAL MANAGEMENT LP
Large shareholder
|
57.000
+1.6%
2,39
136.127 USD
|
57.000
+1.6%
|
2,39
|
136.127 USD
|
|
|
2008-06-26 |
2007-11-06 |
K
Kauf
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
29.000
+0.6%
2,43
70.392 USD
|
29.000
+0.6%
|
2,43
|
70.392 USD
|
|
|
2008-06-26 |
2007-11-06 |
K
Kauf
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
7.000
+0.1%
2,43
16.991 USD
|
7.000
+0.1%
|
2,43
|
16.991 USD
|
|
|
2008-06-26 |
2007-11-06 |
K
Kauf
|
BVF PARTNERS L P/IL
Indirect Beneficial Owner
Large shareholder
|
11.000
+0.2%
2,43
26.700 USD
|
11.000
+0.2%
|
2,43
|
26.700 USD
|
|
|
2007-11-06 |
2007-11-02 |
K
Kauf
|
STUPPIN JOHN B
Nicht geschäftsführender Verwaltungsratsmitglied
|
43.600
+42.0%
2,75
119.900 USD
|
43.600
+42.0%
|
2,75
|
119.900 USD
|
|
|
2007-11-06 |
2007-11-02 |
K
Kauf
|
Fletcher William A
Nicht geschäftsführender Verwaltungsratsmitglied
|
43.600
+inf%
2,75
119.900 USD
|
43.600
+inf%
|
2,75
|
119.900 USD
|
|
|
2007-11-06 |
2007-11-02 |
K
Kauf
|
COHEN ABRAHAM E
Nicht geschäftsführender Verwaltungsratsmitglied
|
43.600
+58.1%
2,75
119.900 USD
|
43.600
+58.1%
|
2,75
|
119.900 USD
|
|
|
2007-11-06 |
2007-11-02 |
K
Kauf
|
SOFAER ABRAHAM D
Nicht geschäftsführender Verwaltungsratsmitglied
|
43.600
+64.8%
2,75
119.900 USD
|
43.600
+64.8%
|
2,75
|
119.900 USD
|
|
|
2007-11-01 |
2007-10-31 |
K
Kauf
|
CARLSON CRAIG W
VP and Chief Financial Officer
Führungsperson
|
1.000
+inf%
2,62
2.620 USD
|
1.000
+inf%
|
2,62
|
2.620 USD
|
|
|
2007-11-13 |
2007-10-30 |
K
Kauf
|
Levy David E
VP of Clinical Development
Führungsperson
|
10.000
+321.0%
2,63
26.300 USD
|
10.000
+321.0%
|
2,63
|
26.300 USD
|
|
|
2007-02-23 |
2007-02-22 |
V
Verkauf
|
FREIMAN PAUL E
President and CEO
Geschäftsführender Verwaltungsratsmitglied
|
64.563
-39.1%
2,61
168.535 USD
|
64.563
-39.1%
|
2,61
|
168.535 USD
|
|
|
2007-02-23 |
2007-02-21 |
V
Verkauf
|
FREIMAN PAUL E
President and CEO
Geschäftsführender Verwaltungsratsmitglied
|
10.437
-15.8%
2,73
28.474 USD
|
10.437
-15.8%
|
2,73
|
28.474 USD
|
|
|
2007-02-23 |
2007-02-21 |
V
Verkauf
|
FREIMAN PAUL E
President and CEO
Geschäftsführender Verwaltungsratsmitglied
|
25.000
-31.0%
2,73
68.205 USD
|
25.000
-31.0%
|
2,73
|
68.205 USD
|
|
|
2007-02-15 |
2007-02-14 |
V
Verkauf
|
ELIOT THEODORE
Nicht geschäftsführender Verwaltungsratsmitglied
|
19.300
-51.3%
2,65
51.145 USD
|
19.300
-51.3%
|
2,65
|
51.145 USD
|
|
